Procalcitonin and High APACHE (Acute Physiological and Chronic Health Evaluation) Level Are Associated with the Course of Acute Kidney Injury in Patients with SARS-CoV-2Article Published on 2022-10-072022-11-15 Journal: International journal of clinical practice [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age AKI Analysis association average C-reactive protein Cell chronic D-dimer demonstrated diagnosis of SARS-CoV-2 ferritin Hospital admission Hospitalized implicated incidence infected with SARS-CoV-2 Inflammation Inflammatory marker Injury investigated Juan KDIGO kidney Kidney function Kidney injury lactate dehydrogenase Level mechanism outcome Patient patients hospitalized performed phosphate Pneumonia predictor procalcitonin procalcitonin level prospective cohort study RT-PCR SARS-CoV-2 survival systemic inflammation virus were recorded with COVID-19 [DOI] 10.1155/2022/1363994 PMC 바로가기
A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation studyArticle Published on 2022-10-012022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy age Algorithm Boston Care center characteristic Child childhood children clinician collected Connecticut COVID-19 pandemic develop development diagnosed Diagnosis Diego disease distribution Early detection enrolled Eunice Kennedy Shriver External feature febrile febrile illness first stage FIVE foundation group heart hospital hospitals Human illness illnesses Inflammatory initial IQR Kawasaki disease laboratory measurements library Los Angele machine-learning median Medicine MIS-C Patient Prevent retrospective SARS-COV-2 infection severe complications similarity stratified syndrome systemic inflammation Treatment USA validation study Washington [DOI] 10.1016/S2589-7500(22)00149-2 PMC 바로가기
Vitamin D modulates systemic inflammation in patients with severe COVID-19Research article Published on 2022-10-012022-10-05 Journal: Life sciences [Category] 바이오마커, 임상, 치료기술, [키워드] AKT Anti-inflammatory effects attenuate Blood blood sample C-reactive protein clinical setting condition COVID-19 COVID-19 infection D-dimer ELISA evaluate expression Hyperinflammatory ICU IL-17 IL-1β IL-6 immune response immunomodulatory in vitro Inflammatory response intensive care investigated JNK marker material modulate Nasopharyngeal swab pathway Patient patients PBMC Proinflammatory cytokine reveal Serum level severe COVID-19 severity signaling pathway Significance STAT3 stimulated systemic inflammation treated treated patient Treatment untreated patient Vitamin D was used western blotting with COVID-19 [DOI] 10.1016/j.lfs.2022.120909 [Article Type] Research article
Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestationsArticle Published on 2022-10-012022-11-16 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Autopsy Brain calculated case sery CD8 Cell Central nervous system clinical clinical manifestation clinical manifestations correlated correlation COVID-19 described Encephalopathy fatal COVID-19 FIVE highest hospitalisation hypoxic IL-6 illness duration intensive care lesion lesions macrophage activation syndrome microglial microthrombi Neuroinflammation neurological Neurological symptoms Neuropathology no correlation one patient onset of symptoms parameter pathology Patient patients performed Pituitary proportion qRT-PCR quantification retrospective SARS-CoV-2 RNA severe COVID-19 patient systemic inflammation T-cell activation Two patient Vascular [DOI] 10.1016/j.pathol.2022.03.006 PMC 바로가기
Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden HamstersArticle Published on 2022-09-172022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] angiotensin-converting enzyme 2 Blood controls coronavirus disease Coronavirus disease 2019 COVID-19 days post-infection disease early stage Efficacy exhibited favor fibrosis form hamster hamsters hepatocyte ballooning impair induce infected with SARS-CoV-2 Infection Inflammation Inflammatory cytokines less liver Liver fibrosis liver steatosis long-lasting Lung inflammation lung viral load mechanism NASH non-alcoholic steatohepatitis obese obese patient obesity pathophysiologic Patient pulmonary fibrosis relative replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamsters Serum level severity of COVID-19 steatohepatitis sustained systemic inflammation the SARS-CoV-2 Treatment weight loss [DOI] 10.3390/v14092067 PMC 바로가기
Canakinumab in patients with COVID-19 and type 2 diabetes – A multicentre, randomised, double-blind, placebo-controlled trialArticle Published on 2022-09-172022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] 1:1 95 % CI Activation addition Administered adverse event approach assigned Basel blockade BMI canakinumab Clinical outcome contributing to COVID-19 CRP Dexamethasone diabetes died dose double-blind dropped drug Efficacy foundation glycaemic control higher risk hospitalised Hospitalization Hyperinflammatory ICU IL-1beta IL-1β IL-6 IMPROVE Inflammasome innate immune system interleukin-1β intravenous dose less medication multicenter multicentre Novartis Obesitiy. obesity outcome participant Patient patients treated patients with COVID-19 Placebo placebo group placebo-controlled trial primary analysis randomised randomization Randomly reduction Registered reported required SARS-CoV2 SARS-CoV2 infection Science Seven severe COVID-19 significantly Standard-of-care statistically significant statistically significant difference survival Switzerland systemic inflammation tested treated Treatment type 2 diabete university Ventilation with COVID-19 [DOI] 10.1016/j.eclinm.2022.101649 PMC 바로가기 [Article Type] Article
SARS-CoV-2 induced hepatic injuries and liver complicationsArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 진단, 치료기술, [키워드] abnormality acute respiratory syndrome ADE Affect Antibody-dependent enhancement Case fatality rate caused clinician Comorbidity Complication Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patient demonstrated detectable diabetes disease Effect Fecal sample gastrointestinal tract globe HCC hepatic dysfunction hepatic injury hepatocellular Hepatocellular carcinoma hepatocyte highly pathogenic hypertension hypoxia identification Immunopathogenesis in vitro in vivo Infection investigated involved Ischemia liver Liver damage Liver injury mechanism mechanism of liver damage. molecular mechanism multifactorial Patient Psychological reported Research Respiratory samples rising RNA RT-PCR SARS-CoV-2 signaling pathways significantly Stress systemic inflammation Toxicity [DOI] 10.3389/fcimb.2022.726263 PMC 바로가기
Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cellsArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Activation alteration antibodies autoantibodies autoantibody Autoimmune disease autoreactive autoreactive antibody B cell B cells BCR Cell changes in characterized CRP described DN1 DN2 DN3 DN3 cells DN4 double negative elevated elicited Frequency functional heterogenous IFNγ IL-1β IL-6 Immunoglobulin increase increase in Infection Inflammation interferon negative precursor pro-inflammatory cytokine reduction in reported SARS-COV-2 infection SARS–CoV–2 secreting cell serum Severe infection severe SARS-CoV-2 Signaling significantly subset systemic inflammation systemic level TNFα viral infection [DOI] 10.3389/fimmu.2022.988125 PMC 바로가기
Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and FunctionalityArticle Published on 2022-09-042022-11-15 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] activity aggregation ameliorated anti-inflammatory activity Autoimmune disease carboxymethyllysine (CML) cascade caused cholesterol CIGB-258 (Jusvinza) CML co-injection coronavirus disease COVID-19 cytokine Cytokine storm death death rate decrease developmental Efficacy Embryo enhancement exhibited faster ferrous ion Final HDL Heat shock high-density high-density lipoproteins (HDL) highest Hsp60 hyperinflammation infiltration Inflammation Inflammatory inflammatory cells infliximab inhibit injected injection kDa Ligand lipoprotein lowest mechanism neutrophil Pain paralysis Particle peptide plasma protective effect Protein resulting stability Stress Survivability systemic inflammation tissue treated Triglyceride was tested zebrafish [DOI] 10.3390/ijms231710130 PMC 바로가기
Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 InfectionArticle Published on 2022-09-032022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 치료기술, [키워드] acute COVID-19 Biomarker Cell CellSearch characterized children circulating circulating endothelial cells conducted coronary artery lesions correlation COVID-19 damage decrease disease Diseases endothelial Endothelial cell Endothelial dysfunction endothelial injury enrolled incidence Inflammatory Kawasaki disease lesion mechanism Mild MIS-C multicenter multisystem inflammatory syndrome in children New Patient patients pediatric Prospective Study SARS-CoV-2 syndrome systemic inflammation Vascular injury Whole blood [DOI] 10.3390/ijms231710106 PMC 바로가기