Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progressionReview Published on 2022-10-012022-10-05 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] Activation addition Anti-inflammatory anticoagulation Antiviral Asymptomatic carrier C1 inhibitor cascade cascades caused Clinical practice complement complement system Complication Contact contact activation system Coronavirus disease 2019 COVID-19 Critically ill patient death disease driver drug Endothelial cell Evidence Inflammatory inhibitor introduced kallikrein-kinin Kallikrein-kinin system monoclonal antibodies multisystemic myocardial injury pandemic potential benefit prevent disease progression randomized study randomized trials SARS-CoV-2 severe COVID-19 syndrome targeting the disease therapeutic option Thromboembolic events Thromboinflammation Treatment Trial [DOI] 10.1016/j.molimm.2022.08.008 [Article Type] Review
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19Article Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 치료기술, 치료제, [키워드] Activation amplified amplify analyzed blocked Blood Cell chemokine chronic liver disease Chronic Liver Diseases circulating comorbid disease Comorbidity contribute controls correlated COVID-19 COVID-19 patients Critical cytokine cytokine secretion DCLK1 DDCLK1 decrease disease severity dysregulation expression Factor Factors Gain growth factor hospitalized patient Host Hyperinflammatory response immune Immune cell immune response immunosuppressive in viral in vitro infected cells Inflammation Inflammatory cytokine inflammatory pathway inhibition inhibitor Innate immunity involved kinase Live virus liver livers loss of function lung Lung disease Macrophage mononuclear cell mononuclear cells Mortality neutrophil normalized Pathogenesis pathology Patient Peripheral blood potential therapeutic target Prevalence pro-inflammatory profile proinflammatory promoted promoter Protein S100A9 SARS-CoV-2 SARS-CoV-2-infected cell secretion severity of COVID-19 Signaling subject targeting Treatment Viremia virus production virus replication with COVID-19 β-catenin [DOI] 10.1128/jvi.00967-22 PMC 바로가기
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry [DOI] 10.1371/journal.ppat.1010799 PMC 바로가기
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernRBD 및 S2를 표적으로 하는 이중특이성 항체는 SARS-CoV-2 오미크론 및 우려되는 기타 변이체를 잠재적으로 중화합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding bispecific antibodies breadth Breakthrough infection caused concern contagious coronavirus country COVID-19 COVID-19 vaccines Delta demonstrated domain dominant effective Efficacy epitope Epitopes feasible highlighting IMPROVE mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant Omicron variants Other other variant other variants parental Prevent Pseudotyped virus RBD Receptor-binding domain reduced respiratory retained SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 WT specificity Spike protein target targeting tested the spike protein therapeutic treat Vaccine variant variants variants of concern VoC VOCs wild-type [DOI] 10.1128/jvi.00775-22 PMC 바로가기 [Article Type] Article
Differentiation of SARS-CoV-2 Variants Using RT-qPCRs by Targeting Recurrent Mutation Sites: A Diagnostic Laboratory Experience from Multi-Center Regional Study, August 2020-December 2021, Poland재발성 돌연변이 부위를 표적으로 하는 RT-qPCR을 사용한 SARS-CoV-2 변이체의 분화: 다중 센터 지역 연구의 진단 실험실 경험, 2020년 8월-2021년 12월, 폴란드Multicenter Study Published on 2022-08-202022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료기술, 치료제, [키워드] Alpha Alpha variant assigned Beta can be used changed collected conducted COVID-19 Delta delta variant diagnostics differentiation distribution epidemiological epidemiological surveillance experience Kappa Mutation mutations National omicron Omicron variants Poland proportion Rapid Recurrent Regional replaced REPLACED BY RT-qPCR RT-qPCR variant differentiation SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened specimen Surveillance targeting tested time interval variant variants virus [DOI] 10.3390/ijms23169416 PMC 바로가기 [Article Type] Multicenter Study
Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of ConcernACE2 결합 나선을 모방한 D-펩타이드로 SARS-CoV-2의 수용체 결합 모티프 표적화: 오미크론 및 우려되는 미래 변이를 억제하기 위한 교훈Article Published on 2022-08-082022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Alpha approach B.1.1.529 Beta binding blocked concern COVID-19 pandemic demonstrated domain Future high-affinity binding IC50 IC50s in vitro In vitro infection Infection inhibiting inhibitor lesson motif Mutation neutralizing monoclonal antibodies omicron Omicron variant overlapping predicted public interest RBD receptor-binding motif SARS-CoV-2 Spike protein Spread targeting the RBD the spike protein variant VoC VOCs [DOI] 10.1021/acs.jcim.2c00500 PMC 바로가기 [Article Type] Article
The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate강력한 항바이러스 약물 후보로서 SARS-CoV-2 3C 유사 프로테아제에 대한 펩티도미메틱 억제제의 구조 기반 설계Article Published on 2022-08-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C Like protease 3CL 3CL pro acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Anti-viral anti-viral drug applied complexes Compound coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 deficiency described develop drug candidates effective inhibit inhibitor inhibitors inhibitory activity Like Medicine pathogen Peptidomimetic inhibitors potent Prevent Pro protease Protease inhibitor protein-ligand respiratory SARS-CoV-2 screened Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus structure-based design targeting the SARS-CoV-2 Transcription treat viral replication X-ray [DOI] 10.1016/j.ejmech.2022.114458 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysisSARS-CoV-2 엔도리보뉴클레아제 표적화: 체외 분석으로 지원되는 구조 기반 가상 스크리닝Article Published on 2022-08-032022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] Analysis approach Bank binding affinity binding energy cell line Compound compounds Concentration COVID-19 database deep learning Defense Diversity docking drug Drug Bank drug candidate endoribonuclease evade FIVE followed by Hierarchical Host host defense in vitro in vivo inhibitory concentration Interaction interfere life cycle molecular non-structural protein non-structural proteins Nsp15 Precision predict protocol responsible SARS-CoV-2 screened selectivity index shown supported targeting the binding affinity therapeutic effect Viral RNA Virtual screening virus was used were used [DOI] 10.1038/s41598-022-17573-6 PMC 바로가기 [Article Type] Article
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19Review article Published on 2022-08-012022-10-05 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 임상, 치료제, [키워드] activated acute respiratory syndrome anti-inflammatory drug antiviral drugs autophagy Autophagy regulation caused coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm early stage Evidence indicate Infection Infectious disease Inflammasome inhibiting inhibitor involved late stage Lung inflammation NLRP3 NLRP3 inflammasome protein 3 provide Regulation replication of SARS-CoV-2 SARS-CoV-2 Stage targeting the cytokine storm therapeutic potential therapy [DOI] 10.1016/j.clim.2022.109093 [Article Type] Review article