Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteasesSARS-CoV-2 주요 및 뎅기 바이러스 프로테아제에 대한 강력한 벤족사보롤 억제제의 발견Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral agent Antiviral agents biochemical assay Cell Cell culture class contribute cytotoxicity demonstrated Dengue dengue virus DENV-2 Drug development evaluated had no Health inhibit inhibitor M pro membrane MOST penetration protease Proteases Replication RNA virus RNA viruses SARS-CoV-2 stability synthesis target targets [DOI] 10.1016/j.ejmech.2022.114585 PMC 바로가기 [Article Type] Article
Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike proteinArticle Published on 2022-10-012022-11-16 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Amino acid antigenic binding binding interaction change characteristic coronavirus COVID-19 domain entry inhibitors Genetic highlight human Angiotensin-converting enzyme information inhibitor mutated Mutation Mutation informatics physicochemical Protein provide RBD reported resulting SARS-CoV-2 SARS-CoV-2 variants spike spike protein. strain targets the RBD the SARS-CoV-2 the spike protein Variability viral pathogenicity [DOI] 10.1016/j.drudis.2022.06.012 PMC 바로가기
Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticalsArticle Published on 2022-10-012022-11-15 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affinity Antiviral antiviral agent apigenin binding binding domain binding interaction biological activity C-terminal Cancer Cancer cells candidate carried cell line cell lines cells Cinnamomum cinnamon complex Complexes components Compound computational analysis computational approach CTD cytotoxicity death drug candidate Druglikeness effective Efficacy evaluate evaluated examined greater HPLC in silico in vitro in vivo Interaction lack less molecular molecular dynamics MTT N-terminal Naturally NTD nucleocapsid nutraceutical oregano Origanum outcome parsley. plant predicted profile Prophylactic Protein provided Research responsible RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein stability symptomatic targets therapeutic therapeutic drug therapy Toxicity treating COVID-19 Treatment virus was determined was performed worsened [DOI] 10.1111/jfbc.14262 PMC 바로가기
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
Applications of human organoids in the personalized treatment for digestive diseasesArticle Published on 2022-09-272022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] application approach build Chemotherapy Clinical treatment CRISPR-Cas9 digestive digestive system disease Diseases dose Drug screening epithelial facilitated Genetic helping highlight human physiology in vitro include Infection Intervention mechanism model system organ Organoid over pathogenic pathogenic mechanism Patient Perspective physiological Research SARS-CoV-2 targets test model therapy tissue Traditional Treatment [DOI] 10.1038/s41392-022-01194-6 PMC 바로가기
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variantsArticle Published on 2022-09-262022-11-15 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Affinity maturation analysis Analysis antibody Antibody Response Antigen antigens caused cleavage site Combination coronavirus coronavirus determine Evolution fusion peptide immunization immunogen Infection Mutation outbreak predict promote PROTECT RBD expression SARS-CoV-2 variant sequence spike Strains Structure targets the antibody response Vaccine variant variants virus wildtype zoonotic coronavirus [DOI] 10.1371/journal.pcbi.1010563 PMC 바로가기
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagyArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] 2019 coronavirus disease activities acute respiratory disease applied autophagy Bioinformatics analysis characterized clinical coronavirus COVID-19 deficiency determine develop Effectiveness Evidence ferulic acid Genes impacted individuals MAPK1 mechanism mechanisms medication methodology molecular docking molecular docking analysis molecular mechanism network pharmacology number of infected Ontology osteosarcoma pandemic pathway enrichment Patient Patients with cancer pharmacological pharmacological target PIK3R1 Population potential therapeutic target Preclinical Protein regulatory subunit SARS-CoV-2 STAT3 target targets therapeutic therapeutic targets therapeutic targets. Transcription treat treatment for COVID-19 variant [DOI] 10.3389/fendo.2022.971687 PMC 바로가기
In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy CalculationsArticle Published on 2022-09-142022-11-15 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] AAK1 addition Anti-COVID-19 Anti-SARS-CoV-2 Activity applied binding binding free energy binding pattern calculation candidate Combination complexes computational modeling digoxin drug drug repositioning drugs Dynamics energy Enzymes evaluated exhibited FDA-approved drug Free greater in silico inhibitor inhibitors methodology molecular molecular docking molecular dynamic simulations. MPro niclosamide ouabain PLPro Proscillaridin protease Protein provide RdRP repositioning RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease screened suggested target targets tested to define [DOI] 10.3390/molecules27185988 PMC 바로가기
Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune systemArticle Published on 2022-09-122022-11-15 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abnormal immune response abnormality Analysis approach Biomarker can be used cells Coagulation coagulation cascade collected combating complement COVID-19 COVID-19 patient Critical demonstrated disease down-regulated down-regulation evaluate group host response identify identity IgG4 indicate KEGG lipids marker mucosal mucosal immune nasal nasopharyngeal Nasopharyngeal swab noninvasive Pathway analysis Patient patients plasma positive Protein proteome proteomics Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral infection significantly targets thrombotic up-regulated [DOI] 10.1371/journal.pone.0274228 PMC 바로가기
Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2Article Published on 2022-09-072022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activated addition Analysis Anti-inflammation Antiviral antiviral drug approach caused conducted coronavirus 2 COVID-19 disrupting E3 ligase E3 ubiquitin ligase effective ENhance enzyme global pandemic Health highlighting Host Infection Inflammatory responses innate immune response Innate immunity interferon lung epithelial cell Lung epithelial cells mechanism modulate multiomics pathogenesis of SARS-CoV-2 promote Protein proteomic respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein significantly Spread targets the epidemic the Spike therapeutic targets transcriptomic Vaccine viral infection [DOI] 10.1038/s41392-022-01156-y PMC 바로가기