Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesisResearch Published on 2021-07-162022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] accelerated ADME ADMET alkaloid anti-SARS-CoV-2 binding affinity binding energy clinical trials complex Compound compounds COVID-19 COVID-19 vaccine distribution drug-likeness effective exhibited highlight HIV reverse transcriptase in silico in viral inhibitors of SARS-CoV-2 inhibitory investigated involved Ligand mechanism metabolism molecular molecular docking non-structural protein non-structural proteins non-toxic NSP Nsp3 Nsps Pathogenesis Pathways Polyphenolics predicted property Result SARS-CoV-2 SARS-CoV-2 pathogenesis Seven Structure supplementary material terpenoids Toxicity transcriptase Treatment vital role [DOI] 10.1186/s43141-021-00206-2 PMC 바로가기 [Article Type] Research
Interaction of selected terpenoids with two SARS-CoV-2 key therapeutic targets: An in silico study through molecular docking and dynamics simulations두 개의 SARS-CoV-2 주요 치료 표적과 선택된 테르페노이드의 상호 작용: 분자 도킹 및 역학 시뮬레이션을 통한 in silico 연구Article Published on 2021-07-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, [키워드] 3CL hydrolase ACE2 receptor Amino acid amino acid residue amino acid residues Analysis Antiviral approved drug binding catalytic dyad caused Complete Compound Computational approaches confirmation Contact contact with contrary Course COVID-19 disease docking docking score Drug repurposing effective enzyme growth hydrolase in silico in vitro in vivo inhibit inhibitors inhibitors of SARS-CoV-2 inhibitory Interaction interfere lack Limonoids molecular molecular docking molecular dynamics Molecular dynamics simulation MPro outbreak pharmacokinetic predicted profiles protease Protein provided RBD SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 replication selected spike Spike protein terpenoids the spike protein therapeutic therapeutic target [DOI] 10.1016/j.compbiomed.2021.104538 PMC 바로가기 [Article Type] Article
Antimicrobial Terpenoids from South China Sea Soft Coral Lemnalia sp.Article Published on 2021-05-222023-06-08 Journal: Marine Drugs [Category] 신종인플루엔자, [키워드] Lemnalia sp. antimicrobial activity cytotoxicity soft coral terpenoids [DOI] 10.3390/md19060294 PMC 바로가기 [Article Type] Article
Synthesis of Camphecene and Cytisine Conjugates Using Click Chemistry Methodology and Study of Their Antiviral ActivityArticle Published on 2019-11-012023-06-24 Journal: Chemistry & biodiversity [Category] 신종인플루엔자, [키워드] ‘click’ chemistry. (+)-camphor (−)-Cytisine 1,2,3-triazoles azides camphecene cytotoxicity heterocyclization terpenoids [DOI] 10.1002/cbdv.201900340
In vitro antimicrobial activity on clinical microbial strains and antioxidant properties of Artemisia parviflora임상 미생물 균주에 대한 체외 항균 활성 및 Artemisia parviflora의 항산화 특성Research Published on 2012-11-212024-07-30 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] 세균성이질, [키워드] antimicrobial antioxidant Artemisia radical scavenging activity terpenoids [DOI] 10.1186/1476-0711-11-30 PMC 바로가기 [Article Type] Research