Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathologyArticle Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition antibodies antibody Beta Cell coronavirus coronavirus disease COVID-19 COVID-19 vaccines CpG cross-protective develop feature Gamma IgA antibody IgG antibody immunopathology Infection initial intranasal intranasal vaccination intranasally investigated less lung Lung eosinophilic immunopathology Lymph node mice mucosa nasal nasal mucosa oligonucleotides pandemic potential risk Prevent Protective protective effect reducing Respiratory disease risk SARS-CoV-2 SARS-CoV-2 variant secretory secretory IgA secretory IgA antibody. serum spike-specific IgG subcutaneous vaccination subcutaneously T helper Th1 Th2 Trimeric spike protein upper respiratory tract vaccination Vaccine variant variants viral challenge virus infection viruses [DOI] 10.1016/j.vaccine.2022.08.049 PMC 바로가기
A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunityArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition amplified Antibody Response antigen expression attenuate B.1.351 B.1.617.2 Beta caused CD3 CD4 CD8 cell-mediated immune Cell-mediated immunity Cellular immune response Convalescent patients COVID-19 COVID-19 vaccine cytokine response Delta disease severity displaying dual-antigen saRNA vaccine elicit hamsters humoral immune response induce lower dose mice mRNA vaccine mutated N antigen Neutralizing antibody response Neutralizing antibody titer PROTECT Proteins RNA RNA vaccine S-RBD SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants self-amplifying RNA spike T cell Th1 vaccination variant variants of concern Viral load [DOI] 10.1016/j.ymthe.2022.04.014 PMC 바로가기
Immune response in ofatumumab treated multiple sclerosis patients after SARS-CoV-2 vaccinationArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] alteration anti-CD20 anti-CD20 therapy antibody applied approach B cell caused CD4 Cellular immune response cellular immunity characterized Complete decrease Delta disorder dosage Effect elicit Frequency healthy controls humoral humoral immune response immune Immune cell immune cells immune response Immunosuppression implication information investigated mean treatment duration Multiple multiple sclerosis neutralization capacity Ofatumumab ofatumumab. omicron pandemic Patient preserved Regulatory T cell SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant sclerosis subcutaneously subpopulation sustained T cell T cell response T helper Th1 titer treated treated patient Treatment Tregs vaccination was impaired wild type [DOI] 10.3389/fimmu.2022.980526 PMC 바로가기
A Novel Single-Stranded RNA-Based Adjuvant Improves the Immunogenicity of the SARS-CoV-2 Recombinant Protein VaccineArticle Published on 2022-08-242022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] activate acute respiratory syndrome adjuvant adjuvants aluminum China Combination coronavirus CpG effective elevated Emergency use authorization Genome hydroxide immune immune response immunogenicity Innate immunity levels of antibody mice Neutralizing antibody titer novel novel adjuvant omicron Protein RBD Receptor binding domain recombinant recombinant RBD protein Research SARS-CoV-2 SARS-CoV-2 recombinant protein vaccine signaling pathway single-stranded single-stranded RNA-based adjuvant. subunit Th1 Th2 the antibody response the SARS-CoV-2 Vaccine was used ZF2001 [DOI] 10.3390/v14091854 PMC 바로가기
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Specific Adaptive Immunity in COVID-19 Survivors With Asthma천식이 있는 COVID-19 생존자의 SARS-CoV-2-특이적 적응 면역Article Published on 2022-07-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive allergy analyzed Asthma asthmatic asthmatic patient benefit Blood Cell Clinical characteristics convalescent correlated COVID-19 COVID-19 patient discharge eosinophil Follow-up healthy control Humoral immunity immune immune memory Immunity individual Lymphocyte subsets memory B cell memory T cells NAb NAbs Neutralization assay Neutralizing antibodies no statistical difference Non-COVID-19 not significantly different Patient percentages positively correlated SARS-CoV-2 pseudotyped virus SARS-CoV-2 specific antibodies SARS-CoV-2-specific neutralizing antibody skewed subjects survivor T cell T cell response T cell responses Th1 Th17 cell Treg Treg cell virus infection virus-specific T cell [DOI] 10.3389/fimmu.2022.947724 PMC 바로가기 [Article Type] Article
Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccinesResearch article Published on 2022-07-092022-10-05 Journal: iScience [Category] 비임상, [키워드] Antigen binding collected conjugate Conjugates crosslinked demonstrated domain effective Efficacy ENhance functional generate hACE2 immunology isolate mice pandemic persist Protein Pseudovirus neutralization assays RBD SARS-CoV-2 SARS-CoV-2 vaccine sera Th1 Vaccine variant variants Virology [DOI] 10.1016/j.isci.2022.104739 [Article Type] Research article
RBD decorated PLA nanoparticle admixture with aluminum hydroxide elicit robust and long lasting immune response against SARS-CoV-2수산화알루미늄이 포함된 RBD 장식 PLA 나노입자 혼합물은 SARS-CoV-2에 대한 강력하고 오래 지속되는 면역 반응을 이끌어냅니다.Article Published on 2022-07-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome aluminum antibody Antibody Response Antigen binding caused Characteristics circumvent Combination coronavirus COVID-19 COVID-19 vaccine develop E. coli elicit elicited expressed expression generate global pandemic hydroxide immune response immunization lactic acid limitations long-lasting mammalian memory Memory antibody response mimicking neutralization neutralize plaque Polymeric nanoparticles Protein-subunit vaccine provided RBD Receptor binding domain Result robust SARS-CoV-2 SARS-CoV-2 vaccine secondary antibody subunit Subunit vaccine Th1 Th2 Vaccine vaccine production virus infection Virus neutralization [DOI] 10.1016/j.ejpb.2022.05.008 PMC 바로가기 [Article Type] Article
The effect of age on the magnitude and longevity of Th1-directed CD4 T-cell responses to SARS-CoV-2Article Published on 2022-07-012023-07-08 Journal: Immunology [Category] COVID19(2023년), [키워드] age CD4 T cell flow cytometry SARS-CoV-2 Th1 [DOI] 10.1111/imm.13475 PMC 바로가기
Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum폴리(I:C) 플러스 명반과 관련된 SARS-CoV-2 삼량체 스파이크 단백질의 면역원성Article Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition adjuvant adjuvants alum antibody B cell BALF Bronchoalveolar lavage fluid CD4 CD8 Cellular immune response Combination domain ELISA enzyme evaluated expected germinal centers IgA IgG IgG anti-spike antibody IgG1 IgG2a immunization immunogenicity immunosorbent in vitro inactivated induce intradermal route lung Lung inflammation mice Neutralization assay Neutralizing titer neutralizing titers neutrophil recruitment New Poly (I:C) poly(I:C positive prefusion produced producing Protein RBD reduced reduction in required SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus serum spike Spike protein Subtypes supported T cell Th1 Th1 phenotype the SARS-CoV-2 trimeric vaccination Vaccination strategy Vaccine [DOI] 10.3389/fimmu.2022.884760 PMC 바로가기 [Article Type] Article