Determinants of Immune Response to Anti-SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients: A Prospective Cohort Study신장 이식 수혜자의 Anti-SARS-CoV-2 mRNA 백신에 대한 면역 반응의 결정 요인: 전향적 코호트 연구Article Published on 2022-04-012022-09-12 Journal: Transplantation [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% confidence interval acute respiratory syndrome affecting analyzed antibody contrary coronavirus coronavirus disease Cutoff depleting determinant Effectiveness epitope evaluated exhibited Factor humoral immune response independent infected with SARS-CoV-2 interferon gamma kidney transplant recipient mRNA mRNA vaccines mycophenolate Odds ratio Patient Prospective prospective cohort study response S1 and S2 SARS-CoV-2 sensitivity Seroconversion shown significantly more Specific T-cell response specificity Spike protein subset subunit sustained tested the interferon therapy Transplant vaccination Vaccine [DOI] 10.1097/TP.0000000000004044 PMC 바로가기 [Article Type] Article
Study of the effects of interferon β-1a on hospitalized patients with COVID-19: SBMU Taskforce on the COVIFERON study입원한 COVID-19 환자에 대한 인터페론 β-1a의 효과 연구: COVIFERON 연구에 대한 SBMU 태스크포스Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] addition Antiviral conducted control group coronavirus disease Coronavirus disease 2019 COVID-19 died Effect Efficacy group hospital Hospital admission Hospital stay Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients IFN-β1a immunomodulatory functions IMPROVE indicated innate immune system interferon Interferon β-1a interferons Iran median Mortality mortality rate no statistically significant difference outcome outcome. P-value Patient patients treated progression Randomized controlled trial regimen Retrospective study selected Severe case severe cases severe COVID-19 standard care standard treatment statistically statistically significant difference Tehran the interferon two group two groups [DOI] 10.1002/jmv.27475 PMC 바로가기 [Article Type] Article
Tracing the SARS-CoV-2 infection on the ocular surface: Overview and preliminary corneoscleral transcriptome sequencing안구 표면의 SARS-CoV-2 감염 추적: 개요 및 예비 각막 공막 전사체 시퀀싱Article Published on 2022-04-012022-09-11 Journal: Experimental eye research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] absence ADAMTS4 Analysis AQP5 associable caused Cluster Clusters component Cornea Corneal Corneoscleral ring COVID-19 CTRL Cytokines DEGs differentially expressed gene Differentially expressed genes Donor down-regulated gene down-regulated genes enrichment analysis Eye bank gene expression profile Gene ontology Genes genomic genomic RNA GO analysis GO term IL6 Illumina inactive indicated infected individual infected individuals Infection interferon interferon pathway ISG ISG15 ISGs Local Manifestations MMP1 modulation molecular mechanism molecular mechanisms ocular Ocular surface pathway PCA PCA analysis performed Perturbation positive Post-mortem principal Principal component principal component analysis proinflammatory cytokines Protective qRT-PCR RNA RNA-sequencing RSAD2 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2. several gene several genes Support tears the interferon the SARS-CoV-2 tissue tracing transcriptional Transcriptome transcriptome analysis transcriptome sequencing virus was performed [DOI] 10.1016/j.exer.2022.108975 PMC 바로가기 [Article Type] Article
Viral Interference between Respiratory VirusesPerspective Published on 2022-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome airway epithelial cell animal model antagonistic cellular circulation coronavirus coronavirus disease COVID-19 demonstrated ENhance evaluated expected Host human metapneumovirus Human rhinovirus Immunity in viral infect Infection Influenza virus Innate immunity Interaction interactions Interference interferon Intervention involved lifted mechanism Multiple nonspecific offer pandemic positive prevented reduce Replication respiratory respiratory infections respiratory syncytial virus respiratory tract respiratory virus respiratory viruses resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 susceptible synergistic the interferon viral interference virus viruses zoonoses [DOI] 10.3201/eid2802.211727 PMC 바로가기 [Article Type] Perspective
A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?Review Published on 2022-01-292022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activating acute respiratory syndrome Anti-inflammatory Antioxidative antiviral property caused cellular homeostasis characterized clinical clinical manifestation complications coronavirus coronavirus disease COVID-19 Degradation dengue virus Ebola virus functions heme heme oxygenase 1 Hepatitis virus Human Human immunodeficiency virus IFN Infectious disease Inflammatory inflammatory disease influenza A virus Injury involved kidney lung matter nervous system oxidative Oxygenase pathway protective role rate-limiting enzyme Relevance Replication Research Respiratory failure respiratory syncytial virus SARS-CoV-2 Symptom systemic hyperinflammation the interferon viral infection viral infections Zika virus [DOI] 10.3390/antiox11020276 PMC 바로가기 [Article Type] Review
RNA-RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infectionSARS-CoV-2와 숙주 사이의 RNA-RNA 상호 작용은 COVID-19 감염 동안 바이러스 발달 및 진화에 도움이 됩니다Article Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 변종, [키워드] Absorption addition approach benefit coincidence collected COVID-19 COVID-19 infection dataset Diseases Evolution FIVE five group five groups Genes Genome genomic genomic RNA Host host cells host immune system host miRNA IL6R immune immune response immune system immune-related gene immune-related genes infect Infectious diseases Interaction interferon interleukin miRNA miRNA. miRNAs mutant strain Pathogenesis pathogenicity pathway Pathways Perspective PPI predicted protein-protein interaction regulate reported RNA-RNA interaction RNA–RNA interaction SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection signaling pathway signaling pathways significantly survival target targets the interferon the SARS-CoV-2 genome [DOI] 10.1093/bib/bbab397 PMC 바로가기 [Article Type] Article
Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon PathwayImmunology Published on 2022-01-132022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] administration Against Analysis analysis antiviral activities caused cytokine response demonstrated diarrhea differentially expressed disease dose Effect epidemic diarrhea evaluate the effect expression group growth homeostasis IL-6 IL-8 Infection inhibited interferon intestinal mechanism monolaurin Mutation no significant effect pathogen pathway Pathways PEDV Piglets Porcine epidemic diarrhea virus Prevent promote promoted protective effect Protein proteomics Regulating Replication Result significantly the interferon virus virus replication [DOI] 10.3389/fimmu.2021.797476 PMC 바로가기 [Article Type] Immunology
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 Research Published on 2022-01-132022-10-05 Journal: Nature cell biology [Category] SARS, 치료제, [키워드] ABBV-744 ACE2 ACE2 expression antiviral response binding block BRD2 clinical trial conducted Control COVID-19 CRISPRi screen epithelia epithelial cell evaluated hamsters highlight host cell receptor host response human cell human cells human lung inhibited inhibitor initiated nasal pathway pharmacological Protein receptor ACE2 reducing regulate required SARS-COV-2 infection SARS-CoV-2 replication spike the interferon therapeutic target Transcription turn [DOI] 10.1038/s41556-021-00821-8 [Article Type] Research
Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway EpitheliumReview Published on 2022-01-132022-10-30 Journal: Medicina [Category] COVID-19, [키워드] accelerated activate Activation adaptive affecting airway epithelial cell airway epithelial cells airway epithelium Antiviral antiviral response antiviral therapy cascade characterized contribute COPD death Defense Deterioration disease severity effective Epidemic epithelium exhibit facilitate healthy Hospitalization Host IFN IFN signaling Immune homeostasis Immunity impairment increased risk Inflammatory mediators Inhaled Interaction interferon signaling Lower respiratory tract lung lung disorder Lung function mechanism mechanisms Mortality pathogen Patient patients pulmonary inflammation reduce Research respiratory respiratory virus respiratory virus response resulting secondary bacterial infection secreting severe disease Signaling subsequent susceptibility susceptible the interferon therapeutic intervention understanding viral infection virus virus clearance [DOI] 10.3390/medicina58010121 PMC 바로가기 [Article Type] Review
Systematic identification of NF90 target RNAs by iCLIP analysisArticle Published on 2022-01-102022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Analysis Biomarkers carried Cell Biology cell line cellular physiology cellular RNA crosslinking determine embryonic encoded protein expression levels Factor fibroblast HEK-293 identify ILF3 immune response Immunological response immunology immunoprecipitation implicated Infection investigated involved IRF3 IRF9 metabolism modulating Molecular biology Molecular medicine mRNA mRNAs offer pathway Protein RNA subset Support target targets the interferon the SARS-CoV-2 translation viral infection [DOI] 10.1038/s41598-021-04101-1 PMC 바로가기 [Article Type] Article