Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 diseaseS1 소단위를 발현하는 뉴캐슬병 바이러스 벡터를 사용한 햄스터의 비강내 예방접종은 SARS-CoV-2 질병으로부터 동물을 보호합니다Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administer administration animals breath claimed coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical effective Efficacy elicited expressing hamster hamsters human clinical trial humoral immune responses immune responses long term lung damage mice Neutralizing antibodies newcastle disease virus pandemic phase prevented PROTECT Protective recent recorded recorded history reduced respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 disease severe acute respiratory syndrome Coronavirus short term significantly the disease the S1 subunit vaccination Vaccine vaccine candidate variant vectored vaccine Viral Viral load while [DOI] 10.1038/s41598-022-13560-z PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response After Heterologous Immunizations With ChAdOx1/BNT162b2 in End-Stage Renal Disease Patients on Hemodialysis혈액 투석 중인 말기 신장 질환 환자에서 ChAdOx1/BNT162b2로 이종 면역 접종 후 중증 급성 호흡기 증후군 코로나바이러스 2 항체 반응Article Published on 2022-06-062022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-RBD Anti-RBD IgG BNT162b2 center ChAdOx1 ChAdOx1 vaccine coronavirus 2 COVID-19 dialysis disease domain dose Effect enrolled first dose Government Hemodialysis Heterologous heterologous vaccination hospital humoral IgG immunization intervals Korean Kyung Hee University median Patient positive response RBD respiratory response SARS-CoV-2 second dose significantly the S1 subunit the spike protein vaccination was measured [DOI] 10.3389/fimmu.2022.894700 PMC 바로가기 [Article Type] Article
Receptor binding domain-IgG levels correlate with protection in residents facing SARS-CoV-2 B.1.1.7 outbreaks수용체 결합 도메인-IgG 수준은 SARS-CoV-2 B.1.1.7 발병에 직면한 거주자의 보호와 상관관계가 있습니다.Article Published on 2022-06-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody Antibody Response antigenemia association B.1.1.7 binding BNT162b2 BNT162b2 vaccine Chain Reaction COVID-19 death domain dose Efficacy humoral IgG levels in vitro incidence information Limited Nasopharyngeal swab nasopharyngeal swab test Neutralizing Neutralizing antibodies nucleocapsid nucleocapsid antigenemia nursing home nursing homes outbreak polymerase chain polymerase chain reaction positive Post-vaccine qPCR RBD reduction residents reverse-transcriptase polymerase chain reaction risk risk factor RT-qPCR S1 subunit SARS-CoV-2 SARS-CoV-2 B.1.1.7 Serum Neutralization Serum neutralizing antibody Seven severe COVID-19 severe symptoms Symptom Symptoms tested the S1 subunit Vaccine was measured [DOI] 10.1111/all.15142 PMC 바로가기 [Article Type] Article
Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2SARS-CoV-2 S1-RBD와 수용체 ACE2 간의 항원 교차 반응성Article Published on 2022-05-042022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome addition amino acid residue Analysis analyzed angiotensin converting enzyme 2 angiotensin-converting enzyme 2 anti-ACE2 antibody antibody Antibody binding antigenic autoantibody bind binding Control coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical cross-react cross-reactivity denatured disease severity docking domain enzyme epitope higher affinity human cell increase in indicated mAb measurement mechanism mice molecular molecular mimicry monoclonal antibody overlapping patients with COVID-19 peptide positive correlation protein-protein interaction receptor receptor ACE2 recognize responsible SARS-CoV-2 SARS-COV-2 infection sera Serum level significantly significantly higher the binding affinity the S1 subunit the spike protein transmission electron microscopy virus western blotting [DOI] 10.3389/fimmu.2022.868724 PMC 바로가기 [Article Type] Article
Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.Article Published on 2022-05-032022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin antibodies antibody apex B.1.351 B.1.617.2 bind CDR3 complex structure conformational coronavirus CoV COVID-19 cryo cryo-EM Cryoelectron microscopy dose Dromedary dromedary camel nanobody VHH Epitopes expressing hACE2 heterodimer high affinity human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 humans involved MERS-CoV Middle East Middle East respiratory syndrome Middle East Respiratory Syndrome CoV nanobodies nanobody neutralization activity neutralize Neutralizing neutralizing antibody nonoverlapping epitope nonoverlapping epitopes platform Protein RBDs Receptor-binding domain receptor-binding domains recognize reservoir residue S1 subunit S1/S2 S2 subunit SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single-domain antibody syndrome target the RBD the S1 subunit therapeutic use transgenic mice transmitted trimer unique variant variants variants of concern viruses [DOI] 10.1073/pnas.2201433119 PMC 바로가기 [Article Type] Article
Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19펩티드 기반 치료제: COVID-19에 대한 새로운 잠재적 치료제Review Published on 2022-05-012022-09-11 Journal: Thérapie [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] antimicrobial peptide antiviral activity Antiviral agents blocked causative agent cell membrane cleave clinical trials COVID-19 COVID-19 outbreak drug drugs feasibility form fusion hACE2 host cell host cell membrane Human humans In silico method inhibitor Interaction intestine intestines lactoferrin lung Lungs mechanism MERS outbreak pandemic peptide peptide-based peptides Peptides-based therapeutics positive-sense RNA virus potential therapeutic agent RNA virus S protein S protein-hACE2 interaction S1 subunit S2 subunit SARS-CoV-2 shown the S1 subunit the SARS-CoV-2 therapeutic viral envelope viral infection [DOI] 10.1016/j.therap.2021.09.007 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)AZD1222(ChAdOx1 nCoV-19) 백신을 접종한 쥐의 시험관 내 SARS-CoV-2 스파이크 단백질 발현 및 혈액학적 효과Article Published on 2022-04-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adenovirus Adenovirus-vectored vaccine AZD1222 AZD1222 (ChAdOx1 nCoV-19) blood cell cells ChAdOx1 ChAdOx1 nCoV-19 change cleavage cleaved COVID-19 COVID-19 vaccination COVID-19 vaccine detectable Disease progression Effect Evidence expected expression hematologic hematology parameter Hematology parameters host cell host cells Host immune response host immune responses immediate effect immediate effects immune responses immunization immunohistochemistry in vitro in vivo Infection innate immune response intramuscular intravenous investigated mice morbidity morbidity and mortality nCoV neutrophil occurred parameters plasma concentration Platelet platelet activation platelet and white blood cell parameters. produced promote Protein prothrombotic state Respiratory failure response risk S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera severe COVID-19 spike spike glycoprotein Spike protein the S1 subunit undetectable vaccination vectored vaccine vehicle Viral Viral particles White blood cell [DOI] 10.3389/fimmu.2022.836492 PMC 바로가기 [Article Type] Article
Assessing humoral immune response after two doses of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthcare workers의료 종사자의 비활성화된 SARS-CoV-2 백신(CoronaVac) 2회 접종 후 체액성 면역 반응 평가Observational Study Published on 2022-04-012022-09-11 Journal: Public health [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] Abbott absence age anti-Spike IgG antibody Assessing blood sample Blood samples CoronaVac COVID-19 pandemic cutoff value declined detection dose female first dose greater HCW HCWs healthcare worker Healthcare workers highest humoral immune response Humoral immunity Immunity immunoassay immunogenic immunogenicity Immunoglobulin Immunoglobulin G inactivated inactive Infection investigated Ireland male men Microparticle observational study performed positive prospective observational study receptor Receptor-binding domain reported risk S1 subunit SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 vaccine second dose second dose of vaccine Seropositivity significantly Spike protein susceptible the receptor-binding domain the S1 subunit the spike protein vaccination Vaccine virus was performed women [DOI] 10.1016/j.puhe.2022.01.011 PMC 바로가기 [Article Type] Observational Study
Generation and persistence of S1 IgG and neutralizing antibodies in post-COVID-19 patients코로나19 이후 환자의 S1 IgG 및 중화항체 생성 및 지속Article Published on 2022-04-012022-09-12 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age antibody Antibody Response Asymptomatic COVID-19 ELISA exponential decay model Gender Generation greater groups highest IgG antibody immune response Immunity Infection Logistic long-lasting male Model NAb NAbs Neutralizing antibodies neutralizing antibody no statistical difference Older other coronaviruses participants with SARS-CoV-2 persistence post-COVID-19 patient Post-infection Region Reinfection S1 IgG SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 the disease the S1 subunit variables was used [DOI] 10.1007/s15010-021-01705-7 PMC 바로가기 [Article Type] Article
Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다Article Published on 2022-04-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1 [DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article