Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectinin-vitro 효과적인 약물 Ivermectin과 Covid-19 및 importin-α의 확인 된 단백질 표적에 대한 결합 메커니즘 및 구조적 통찰력Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] (RdRp Antiviral antiviral drug approved cell line complex COVID-19 drug complexes drug design effective FDA followed by free energy Helicase identification Importin In-vitro Interaction involved Ivermectin lead mechanism mechanism of action MM/PBSA molecular molecular dynamics molecular target molecular target. Protein protein-drug complex protein-drug complexes RdRP reduce reported reveal RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 selectivity stability target the cell the strongest triggered while [DOI] 10.1080/07391102.2020.1839564 PMC 바로가기 [Article Type] Article
Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity스트레스 대처 : Covid-19 심각도의 바이오 마커로서 미토 카인 GDF-15Review Published on 2022-02-162022-08-31 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] adaptive metabolic response Biomarker Cancer cancers coping COVID-19 COVID-19 cytokine storm cytokine disease disease severity disease tolerance GDF-15 growth factor hypoxia immune infections inflammatory conditions involved limitations marker mechanism mediator metabolism mitochondrial potential mechanism potential mechanisms predictor protective role Regulation report SARS-CoV-2 severity Stress the strongest therapeutic interventions tissue tissue damage Tolerance transforming growth factor Viral viral infection viral infections [DOI] 10.3389/fimmu.2022.820350 PMC 바로가기 [Article Type] Review
Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-BSARS-COV-2 mRNA 백신 PTX-Covid19-B의 전임상 평가Research Article Published on 2022-01-192022-09-10 Journal: Science Advances [Category] 변종, 비임상, 신약개발, 진단, [키워드] adverse effect adverse effects Alpha Beta breath candidate Cellular immune response clinical trial clinical trials COVID-19 pandemic Delta description effective effective vaccine elicited Gamma hamster hamsters Health Canada humoral immune immune responses immunogenic indicated initial lineages lung mice mouse mRNA vaccine neutralize Neutralizing antibody response Phase 2 Preclinical respiratory robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sera the strongest upper respiratory tract vaccination [DOI] 10.1126/sciadv.abj9815 PMC 바로가기 [Article Type] Research Article
Healthcare institutions’ recommendation regarding the use of FFP-2 masks and SARS-CoV-2 seropositivity among healthcare workers: a multicenter longitudinal cohort study의료 종사자 간의 FFP-2 마스크 사용 및 SARS-COV-2 혈청 양성 사용에 관한 의료 기관의 권고 : 다기관 종단 코호트 연구Multicenter Study Published on 2022-01-102022-09-01 Journal: Antimicrobial Resistance and Infection Control [Category] 진단, 치료기술, [키워드] 95% CI analyzed association baseline Care chemiluminescence immunoassay contact with COVID-19 COVID-19 incidence COVID-19 patient COVID-19 patients Effect evaluated exposure to Face mask Face masks FFP-2 and surgical masks Follow-up HCW HCWs Health Health care healthcare Healthcare workers immunoassay incidence Local longitudinal cohort study Mask Mask policy Masks multicenter multivariable analyses multivariable analysis multivariable logistic regression not affect pandemic participant Probability questionnaire recruited Result risk factor Risk factors Roche Diagnostics SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection sera Seroconversion seroconversion rate seroconversion rates Significant supplementary material surgical Switzerland the strongest univariable [DOI] 10.1186/s13756-021-01047-x PMC 바로가기 [Article Type] Multicenter Study
The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.Research Article Published on 2022-01-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used [DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article
Impact of Changes in Infection Control Measures on the Dynamics of COVID-19 Infections in Schools and Pre-schools감염 통제 조치 변경이 학교 및 유치원의 COVID-19 감염 역학에 미치는 영향Observational Study Published on 2021-12-202022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, 임상, [키워드] 95% CI analyzed change changes in children combinations Control control measures COVID-19 COVID-19 infection COVID-19 infections debate decrease Dynamics evaluate event Face mask Face masks Factor Germany identify Impact index case indicate infection control likelihood Linear regression model matter measure Model MONITOR multicollinearity multivariate multivariate regression analysis number of students obligation observational study open outbreak Outbreaks positive prospective observational study reduction in regression analysis Regression model routine surveillance data SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variants School Schools schools and pre-schools secondary case secondary cases significant increase surveillance data tested the strongest variable wear face masks [DOI] 10.3389/fpubh.2021.780039 PMC 바로가기 [Article Type] Observational Study
Immunogenicity of SARS-CoV-2 infection and Ad26.CoV2.S vaccination in people living with HIVHIV 감염자의 SARS-CoV-2 감염 및 Ad26.CoV2.S 예방접종의 면역원성Major Article Published on 2021-12-102022-09-10 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Ad26.CoV2.S vaccines African clinical trial COVID-19 disease death decrease Delta delta variant disease Effect elicit enrolled examined Frequency HCW Health care Health care worker health care workers higher risk highest HIV HIV infection HIV viremia HIV-negative immunogenicity individuals infected with SARS-CoV-2 Live virus neutralization Neutralization assay neutralization capacity Neutralizing activity no decrease non-responder non-responders participant Participants people living with HIV people with HIV PLWH reduced reduction in reported responders Result SARS-CoV-2 SARS-COV-2 infection South suppression the strongest vaccination Vaccine Viremia with HIV [DOI] 10.1093/cid/ciab1008 PMC 바로가기 [Article Type] Major Article
Early Prediction of Disease Progression in Patients with Severe COVID-19 Using C-Reactive Protein to Albumin RatioC 반응성 단백질 대 알부민 비율을 사용한 중증 COVID-19 환자의 질병 진행 조기 예측Research Article Published on 2021-12-032022-09-10 Journal: Disease Markers [Category] SARS, 바이오마커, [키워드] Admission albumin Analysis Biomarkers C-reactive protein characteristic Clinical deterioration Clinical management coronavirus coronavirus disease Correlation analysis COVID-19 Critical Critical disease Critical illness CRP D-dimer D-dimer levels death Deceased discharged disease Disease progression evaluated group hospital Hospital mortality Hospital stay Hospitalization ICU admission increased risk Invasive mechanical ventilation log Logistic regression analysis lymphocyte Medical resources Mortality multivariate multivariate logistic regression analysis neutrophil Neutrophil-to-lymphocyte ratio on admission Organ failure outcome oxygen oxygen saturation Patient patients patients with COVID-19 Platelet positive correlation predict prediction prognostic biomarker progressed progression progressive disease promote Ratio receiver receiver operating characteristic Result risk risk factor Risk factors risk stratification Sequential Organ Failure Assessment sequential organ failure assessment score severe coronavirus disease severe COVID-19 SpO2 Survivors systemic immune-inflammation index the strongest Treatment Union Hospital utility West Wuhan, China [DOI] 10.1155/2021/6304189 PMC 바로가기 [Article Type] Research Article
Digital SARS-CoV-2 Detection Among Hospital Employees: Participatory Surveillance Study병원 직원 중 디지털 SARS-CoV-2 탐지: 참여 감시 연구Original Paper Published on 2021-11-222022-09-10 Journal: JMIR Public Health and Surveillance [Category] MERS, SARS, 치료기술, [키워드] absence Accuracy aligned Analysis Anomaly average best Chain Reaction characteristic Combination complement correlation COVID-19 Data analysis detection Digital digital epidemiology Disease surveillance eye First wave HCW HCWs Health care Health care worker health care workers hospital implementation individual level Loss loss of taste machine learning muscle pain objective Pain Participants polymerase chain polymerase chain reaction population level positive Positive test predictor prospective cohort random Random forest receiver operating characteristic receiver operating characteristic curve recruited Result runny nose SARS-CoV-2 scatterplot sensitivity SMS Spearman specificity Surveillance Switzerland Symptom Taste test result the strongest training data user with COVID-19 [DOI] 10.2196/33576 PMC 바로가기 [Article Type] Original Paper
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2기존의 중합효소 특이적 T 세포가 혈청 음성 반응을 일으키지 않는 SARS-CoV-2에서 확장Article Published on 2021-11-102022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] abortive infection accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody binding Cell clades clearance of SARS-CoV-2 Cohort complex conserved contribute Coronaviridae coronavirus Coronavirus infection Coronavirus infections cross-protective detectable develop Endemic epitope expand exposure to HCoV HCW HCWs healthcare worker highlight IFI27 Immunological memory in vivo increase in individual Infection memory response memory T memory T cell Neutralization assay neutralization assays pandemic PCR refs Region Replication respiratory response responses RNA polymerase robust RTC SARS-CoV-2 SARS-COV-2 infection seasonal coronavirus Sequence conservation Seroconversion seronegative severe acute respiratory syndrome Coronavirus subclinical infection Support T cell T cells target targets tested the strongest these cell These cells transcribed Transcription Vaccine variant Viral viral control [DOI] 10.1038/s41586-021-04186-8 PMC 바로가기 [Article Type] Article