News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meetingArticle Published on 2022-10-152022-11-16 Journal: Biology open [Category] 유전자 메커니즘, [키워드] Biology Biophysics cell differentiation cellular Circular circular RNAs Community COVID19 disease DNA Dogma highlighting information International involved Italian modulating Molecular biology National New Non-coding RNAs, microRNAs Pandemics Protein provided RNA RNA therapies. RNAs Rome Society Stress Therapies therapy transcript translational [DOI] 10.1242/bio.059597 PMC 바로가기
Surveillance of omicron variants through wastewater epidemiology: Latest developments in environmental monitoring of pandemic폐수 역학을 통한 오미크론 변이체 감시: 전염병의 환경 모니터링에 대한 최신 개발Review Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] assessment B.1.1.529 benefit Biomarker Biomarkers caused contagious disease contagious diseases COVID-19 Early detection early warning environmental health Epidemics epidemiological data Epidemiology Evidence examined Examining followed by Health health information help Human Human health risks IMPROVE infection control infectious Infectious disease information initial Intervention Omicron variant outbreak pandemic plant Prevent Prevention strategy problem progression provided reduce Research SARS-CoV-2 SARS-CoV-2 B.1.1.529 Spread Surveillance the disease Therapies Transmission Treatment variant variant of concern virus wastewater Wastewater epidemiology. water Work environment workstation [DOI] 10.1016/j.scitotenv.2022.156724 PMC 바로가기 [Article Type] Review
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 InfectionArticle Published on 2022-10-142022-11-16 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Adequate approach cancers cardiovascular disease chronic disease Chronic diseases communicable disease complementary coronavirus COVID-19 CVD Diabetes Mellitus dietary dietary supplements effective fasting fatty acids feasible hallmark immunomodulatory Importance Inflammation Inflammatory Intermittent intermittent fasting Modification nutraceutical obesity outcome oxidative oxidative stress Patient Polyunsaturated Post-infection quercetin Randomized controlled trial regimen SARS-CoV-2 Selection severe coronavirus disease suggested systemic Therapies time-restricted eating Treatment variant Vitamin vitamins vitamins. was performed [DOI] 10.3390/nu14204299 PMC 바로가기
When the Dust Has Settled: Calculation of Binding Affinities from First Principles for SARS-CoV-2 Variants with Quantitative AccuracyArticle Published on 2022-10-112022-11-16 Journal: Journal of chemical theory and computation [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy ACE2 active against acute respiratory syndrome affinity angiotensin-converting enzyme 2 antibodies antibody applied Beta binding binding free energy biological processe calculation complex coronavirus coronavirus disease Delta delta variant Diversity dust effective estimate host cell Immune escape immune response information methodology molecular omicron Perspective Predictive principle receptor robust SARS-CoV-2 Support the binding affinity the receptor-binding domain Therapies Transmissibility variant variants widespread wild type [DOI] 10.1021/acs.jctc.2c00604 PMC 바로가기
Systematic Down-Selection of Repurposed Drug Candidates for COVID-19Article Published on 2022-10-062022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] applied approved drug average candidate claimed Compound compounds concern COVID COVID-19 COVID-19 pandemic CoviRx.org Critical curated database disease Diseases drug drug candidate drugs effective Efficacy and safety effort eight evaluate Healthcare system healthcare worker infections mechanism methodology pandemic Prevent provide repurposing Safe safety profile SARS-CoV-2 Scientific community Therapies treating COVID-19 Treatment treatments. Vaccine variants of concern variants of concern (VOC) [DOI] 10.3390/ijms231911851 PMC 바로가기
The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls-a prospective cohort studyArticle Published on 2022-10-052022-11-15 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI analyzed anti-RBD antibodies binding antibody antibody level blood sample bowel collected combination treatment Control controls COVID-19 declined defined disease dose enrolled Factor greater healthy healthy control healthy individuals Humoral immunity identify Immune-mediated inflammatory disease immunosuppressive Immunosuppressive medication Inflammatory bowel disease inhibitor initial interval median Multivariable regression Necrosis participant Patient patients persistence prospective cohort study Protein provided psoriatic arthritis RBD reduction reduction in Rheumatic diseases rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine serologic Serologic response. spike spondyloarthritis Support the receptor-binding domain the SARS-CoV-2 Therapies therapy ulcerative colitis vaccination vaccine dose [DOI] 10.1186/s12916-022-02587-8 PMC 바로가기
Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patientsArticle Published on 2022-10-032022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 anti-TNF antibody Autoimmune booster dose cellular immunity Control COVID-19 case COVID-19 cases cumulative Decline decrease delta variant dose geometric mean titer IgG positivity IgG response Immunity immunogenicity immunosuppressive Inactivated vaccine incidence individuals Logistic regression analysis male multivariate Neutralizing Neutralizing antibodies outcome Patient patients Prednisone Primary outcome reduce reduction in rheumatic disease SARS-CoV-2 IgG SARS-CoV-2 immunity secondary Spread stability Therapies Vaccine vaccine dose [DOI] 10.1038/s41467-022-33042-0 PMC 바로가기
MIS-C: A COVID-19-as sociated condition between hypoimmunity and hyperimmunityArticle Published on 2022-10-032022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] activated Activation acute phase Admission Analysis ATM Autoimmune Autoimmune disease Autoimmune diseases autoimmune pathogenesis autoinflammatory disease Autoinflammatory diseases B cell cellular Characteristics children clearance complication of COVID-19 contribute Critical cytokine response Cytokine storm Cytokines Cytometry demonstrated develop diagnostic biomarker DOCK8 event FCN3 Flow flow cytometry flow cytometry. Genetic Genetic variant healthy control help heterogeneity Hospital admission identified variant IFN IFN-α IFN-β IFN-γ IFNγ IL-10 IL-12p70 IL-17A IL-6 immune dysregulation immunodeficiency immunological induce Inflammatory inflammatory pathway involved knowledge lymphocyte lymphopenia management MCM4 MIS-C MOST multisystemic mutated NCF1 NGS NOD2 organ Pathogenesis pathway Patient patients Population PRF1 reduction serum serum cytokine significant increase syndrome Th1 the disease therapeutic Therapies tissue damage TNF Type variant was increased [DOI] 10.3389/fimmu.2022.985433 PMC 바로가기
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concernArticle Published on 2022-10-032022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody approach B.1.617.2 binding circulating SARS-CoV-2 variant circulating variant class COVID-19 Effect Efficacy Evidence hACE2 hamster in vitro result mice mitigate neutralization neutralization activity Neutralizing activity non-immune Post-infection provide reactive SARS-CoV-2 variant scFv selected several variant single-chain variable fragment synergistic Therapies treat Treatment variants of concern Wuhan strain [DOI] 10.1038/s41467-022-33030-4 PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기