Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic MovementsArticle Published on 2020-12-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome analysis binding bioinformatics cleavage sites complex conserved coronavirus coronavirus Coronaviruses COVID-19 domain driven by dynamic events Evolution Features fixation furin-like cleavage site glycoprotein Host host cell Increased inhibitors molecular dynamics movement Multiple origin preserved PRRA Purifying Receptor binding domain Recombination resulting S glycoprotein SARS-CoV-2 Selection spike spike gene Strong target the SARS-CoV-2 threonine transmissions variant [DOI] 10.3390/ijms22010080 PMC 바로가기 [Article Type] Article
Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli생물막 미세 환경은 대장균에 강력한 적합성을 부여하는 광범위한 적응 아미노산 발효 경로를 유도합니다Research Article Published on 2017-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1-propanol adaptive aerobic Amino acid amino-acid Bacterial bacterial communities balance biofilm cellular change characterized Clostridia competition complex condition conditions contribute Degradation E . coli Enterobacteriaceae Escherichia coli exploration Genetic modifications growth hypoxic hypoxic condition hypoxic conditions identify induce liquid cultures maintain metabolic pathway metabolic pathways metabolism microenvironment pathway physiological responses produced propanol provide reducing threonine Trigger widespread [DOI] 10.1371/journal.pgen.1006800 PMC 바로가기 [Article Type] Research Article
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article