Thromboinflammation – Page 2 – Communicable Diseases Research

C-reactive protein, immunothrombosis and venous thromboembolism

Article

Published on 2022-09-132022-11-15
Journal: Frontiers in Immunology [Category] 바이오마커,

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서

Review

Published on 2022-09-012022-09-11
Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle
[DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review

Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19

Research article

Published on 2022-08-052022-10-05
Journal: EBioMedicine [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 BAL BAL fluid bind Biomarker Bronchoalveolar lavage Bronchoalveolar lavage fluid Coagulation system complexes contribute coronavirus COVID COVID-19 Critical dysregulation explain extracellular traps finding funding help hydrolytic activity Hypothesis increased vascular permeability inflammatory chemokines kallikrein-kinin Kallikrein-kinin system Kallikreins Kinins Leuven mechanically ventilated mechanically ventilated patient median myeloperoxidase NETs Neutrophil extracellular trap observation occur oedema Patient patients without COVID-19 peptide peptides plasma potential treatment option receptor Research SARS-CoV-2 severe COVID-19 severe pulmonary disease Support thromboembolic complication thromboembolic complications Thromboinflammation tissue
[DOI] 10.1016/j.ebiom.2022.104195 [Article Type] Research article

COVID-19 coagulopathy – what should we treat?

Review

Published on 2022-07-012023-07-09
Journal: Experimental Physiology [Category] COVID19(2023년),

[키워드] Anticoagulants ARDS Coagulation coronavirus covid coagulopathy COVID-19 fibrinolytics hypercoagulability pulmonary microvascular thrombosis Thromboinflammation
[DOI] 10.1113/EP089404 PMC 바로가기 [Article Type] Review

Editorial: Complement and COVID-19 Disease

Editorial

Published on 2022-07-012023-07-10
Journal: Frontiers in Immunology [Category] COVID19(2023년),

[키워드] complement system COVID-19 kinin-kallikrein system SARS – CoV – 2 Thromboinflammation
[DOI] 10.3389/fimmu.2022.960809 PMC 바로가기 [Article Type] Editorial

The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?

코로나19 시대 직접 경구용 항응고제의 역할: 항바이러스제와 약물유전학이 제약 요인인가?

Article

Published on 2022-06-222022-09-11
Journal: Croatian Medical Journal [Category] 유전자 메커니즘, 치료제,

Impaired Kallikrein-Kinin System in COVID-19 Patients’ Severity

Observational Study

Published on 2022-06-222022-10-05
Journal: Frontiers in Immunology [Category] 임상,

[키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related
[DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study

Clinical and prognostic significance of C-reactive protein to albumin ratio in hospitalized coronavirus disease 2019 (COVID-19) patients : Data on 2309 patients from a tertiary center and validation in an independent cohort

Article

Published on 2022-05-012023-07-07
Journal: Wiener Klinische Wochenschrift [Category] COVID19(2023년),

[키워드] IL‐6 Pneumonia Prognosis SARS-CoV‑2 Thromboinflammation
[DOI] 10.1007/s00508-021-01999-5 PMC 바로가기

Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19

Research article

Published on 2022-04-142022-10-05
Journal: Blood advances [Category] SARS, 바이오마커, 비임상,

[키워드] activated Activation aggregate amplification amplify amplifying Analysis approach assays binding CD16 Coagulation Combination COVID-19 Critically ill patient driving Evidence Ex vivo exhibited expression fibrinogen function functional high risk highlight HLA-DR hypercoagulability hyperinflammation identify in vitro indicated Inflammation Inflammatory Inflammatory cytokine Inflammatory mediators inflammatory monocyte Interaction interleukin-1β life-threatening mechanism mechanisms monocyte P-selectin pathogenesis of COVID-19 Patient pharmacological Platelet platelet activation Platelets presenting proinflammatory cytokines receptor response RNA-sequencing SARS-COV-2 infection secretion severe COVID-19 Signaling single-cell subset thromboembolic complications Thromboinflammation tissue tumor necrosis factor-α with COVID-19
[DOI] 10.1182/bloodadvances.2021006680 [Article Type] Research article

Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation

COVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애

Immunology

Published on 2022-01-312022-09-11
Journal: Frontiers in Immunology [Category] 바이오마커,

[키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related
[DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology