Safety and immunogenicity of the measles vector-based SARS-CoV-2 vaccine candidate, V591, in adults: results from a phase 1/2 randomised, double-blind, placebo-controlled, dose-ranging trial성인에서 홍역 벡터 기반 SARS-CoV-2 백신 후보 V591의 안전성 및 면역원성: 1/2상 무작위, 이중 맹검, 위약 대조, 용량 범위 시험 결과Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] SARS, 임상, 치료기술, [키워드] Adverse adverse events anti-SARS-CoV-2 assigned convalescent serum COVID-19 COVID-19 disease Culture Day death dose double-blind event fatigue headache healthy humoral immunogenicity immunogenicity Inc. infectious dose injection Injection-site pain Intramuscular injection median multicentre myalgia neutralising antibody occurred Older participant Placebo placebo-controlled randomised response Safety SARS-CoV-2 SARS-CoV-2 vaccine screened secondary secondary outcome Serious Adverse Event Serious Adverse Events serum Sharp single dose subsidiary TCID tissue tissue culture titre titres Trial USA Vaccine [DOI] 10.1016/j.ebiom.2021.103811 PMC 바로가기 [Article Type] Clinical Trial
The theory and practice of the viral dose in neutralization assay: Insights on SARS-CoV-2 “doublethink” effect중화 분석에서 바이러스 용량의 이론 및 실제: SARS-CoV-2 "이중 사고" 효과에 대한 통찰력Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, [키워드] antibodies Cell comparability conditions Culture dose estimation functional immunological responses implementation Infection infective Infective dose insight Live virus lower dose Micro-neutralisation neutralization Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody positive protocol reduced reproducibility SARS-CoV-2 sensitivity specificity Standardization TCID TCID50 tissue tissue culture Viral virus well wild type [DOI] 10.1016/j.jviromet.2021.114261 PMC 바로가기 [Article Type] Article
The effectiveness of various gargle formulations and salt water against SARS-CoV-2SARS-COV-2에 대한 다양한 양치용 제제 및 바닷물의 효과Article Published on 2021-10-152022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] addition Asymptomatic asymptomatic patient asymptomatic patients BSA calculated chlorhexidine chloride condition conditions COVID-19 Culture cytotoxicity disease disease spread effective Effectiveness eliminating erythrocytes European evaluated Formulation gargle Gargling hexetidine inactivation Incubation period infected patient infected patients infectious dose kill log Medical research Microbiology preventive measure preventive measures protocol reducing reduction in risk of transmission salt SAR-CoV-2 SARS-CoV-2 Spearman-Karber Spread Standard tested the disease Thymol tissue tissue culture titre titres Transmissibility Transmission Treatment Vero E6 VERO E6 cells Viral virucidal virus virus titer virus titre Virus titres virus transmission water [DOI] 10.1038/s41598-021-99866-w PMC 바로가기 [Article Type] Article
Hypochlorous acid solution is a potent antiviral agent against SARS‐CoV‐2차아염소산 용액은 SARS-CoV-2에 대한 강력한 항바이러스제입니다.Original Article Published on 2021-09-172022-09-10 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity can be used caused Concentration coronavirus COVID‐19 Culture demonstrated Detection limit Diseases disinfectant evaluated expected flammable foetal bovine serum gastroenteritis HClO hypochlorous acid Impact inactivated incubated infectious dose irritation material Novel coronavirus organic matter pandemic phosphate phosphate‐buffered saline presence or absence purified reduction respiratory responsible Result Saline SARS‐CoV‐2 SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus Significance skin TCID TGEV tissue tissue culture titre Toxicity transmissible gastroenteritis virus virus virus titre was used Wuhan Wuhan, China [DOI] 10.1111/jam.15284 PMC 바로가기 [Article Type] Original Article
A tissue culture infectious dose-derived protocol for testing of SARS-CoV-2 neutralization of serum antibodies on adherent cells부착 세포에서 혈청 항체의 SARS-COV-2 중화 시험을위한 조직 배양 감염 용량 유래 프로토콜Protocol Published on 2021-08-272022-09-01 Journal: STAR protocols [Category] MERS, SARS, 진단, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus adherent adherent cell adherent cells antibody applied Cell culture cell cultures Cell-based Assays convalescent coronavirus Culture cytopathic Cytopathic effect described immunology Increased less Microbiology neutralization neutralization capacity plaque-forming unit protocol reduced required researcher respiratory SARS-CoV-2 SARS-CoV-2 neutralization serum serum antibody tested therapeutic therapeutic antibodies tissue tissue culture virus [DOI] 10.1016/j.xpro.2021.100824 PMC 바로가기 [Article Type] Protocol
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cellsTMPRSS2 발현은 SARS-CoV-2가 숙주 세포를 감염시키는 데 사용하는 진입 경로를 지시합니다Article Published on 2021-08-162022-09-11 Journal: The EMBO Journal [Category] SARS, 유전자 메커니즘, 진단, [키워드] cathepsin L cathepsin L pathway caused Cell cell interaction clinical symptom coronavirus COVID-19 COVID-19 outbreak Culture cytosol demonstrated dependence determine endocytosed Endolysosomes Entry mechanism entry mechanisms entry pathway entry route expressing highlight host cell infect Infection Loss of Smell loss of smell and taste Lung injury overexpression pathway plasma membrane Post-infection protease protease TMPRSS2 proteolytic restored SARS-CoV-2 SARS-COV-2 infection sensitivity target cell target cells Taste tissue tissue culture tissue tropism TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitors virus virus entry [DOI] 10.15252/embj.2021107821 PMC 바로가기 [Article Type] Article
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster ModelCOVID-19 골든 시리아 햄스터 모델에서 폐 영상 및 SARS-CoV-2 항체 반응의 성별 차이Research Article Published on 2021-07-132022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alter animal animal model animal models body mass cause caused causes Chest computed tomography comparable Computed tomography concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cytokine deaths difference dose estradiol euthanized female females greater hamster Hospitalization hospitalizations human population IFN-β IgA response IgA responses IgG IgG antibodies IgG antibody IgM imaging Infection Infectious virus infective Infective dose inoculated interferon intranasally Lungs male Model morbidity Mortality mounted mutant nasal turbinates outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 plasma Pneumonia pulmonary damage RBDs Receptor-binding domain reported respiratory respiratory tissues response S-RBD SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Sex difference sex differences significantly Spike protein TCID the receptor-binding domain the spike protein tissue tissue culture TNF-α Trachea Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α virus virus titers virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1128/mBio.00974-21 PMC 바로가기 [Article Type] Research Article
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study7 개의 상업용 SARS-COV-2 빠른 시점 항원 테스트 비교 : 단일 센터 실험실 평가 연구Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, MERS, SARS, 치료기술, [키워드] 95% CI Abbott Abbott Panbio COVID-19 Ag Rapid Test accelerate Affair AgPOCT AgPOCTs analytical sensitivity Antigen Antigen point-of-care test assays Biocredit COVID-19 Ag Care cassette Cell culture clinical sample clinical samples Concentration coronavirus Coronaviruses COVID-19 COVID-19 Ag Respi-Strip cross-reactivity cumulative Cumulative specificities Cumulative specificity Decision making Endemic endemic human coronavirus energy evaluated False-positive results finding FIVE foundation funding generate HCoV HCoV-HKU1 supernatant HCoV‑229E HCoV‑HKU1 HCoV‑NL63 HCoV‑OC43 Healgen Healgen assay Healgen Coronavirus Ag Rapid Test Cassette Health Health care healthy volunteer healthy volunteers Horizon Infection infectious Laboratory limit of detection Melinda Gate Melinda Gates MERS MERS-CoV Ministry of Health Most patients nal von minden nal von minden NADAL COVID-19 Ag Test outlier overlap PanBio Pathogens Patient patients point-of-care positive public health quantified R-Biopharm ranged Rapid Rapid test RapiGEN RapiGEN BIOCREDIT COVID-19 Ag real-time RT-PCR recombinant SARS-CoV-2 nucleoprotein Research respiratory respiratory pathogen Respiratory pathogens Respiratory samples RIDA Roche Roche-SD Biosensor Roche-SD Biosensor SARS-CoV Rapid Antigen Test RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads sensitivity Seven specificity stored respiratory sample stored respiratory samples Swab Symptoms Test test results tissue culture tissue culture supernatant tissue culture supernatants utility Viral Viral concentration Viral load viral loads virus concentration [DOI] 10.1016/S2666-5247(21)00056-2 PMC 바로가기 [Article Type] Articles
Evaluation of stability and inactivation methods of SARS-CoV-2 in context of laboratory settings실험실 환경에서 SARS-CoV-2의 안정성 및 비활성화 방법 평가Original Investigation Published on 2021-07-012022-09-12 Journal: Medical Microbiology and Immunology [Category] MERS, SARS, 진단, [키워드] acetone acute respiratory disease addition Analysis analyzed Bio safety biosafety level Biosafety Level 3 BSL-3 Caco-2 causative agent Cell culture Corona virus COVID-19 Crystal violet Culture culture media denaturation dose effective Ethanol evaluated guanidine handling heat inactivation inactivation infected cell infected cells Infection Laboratory level 3 lysate lysates lysed lysis buffer media methanol Microscopy molecular Molecular biology Novel coronavirus novel coronavirus SARS-CoV-2 PFA Proteins removal required Research RT-qPCR SARS-CoV-2 Spread stability staining subsequent supernatant supplementary material susceptible TCID tested tissue tissue culture Vero Cell Vero cells viral sample virus [DOI] 10.1007/s00430-021-00716-3 PMC 바로가기 [Article Type] Original Investigation
Multiplex Real-Time Reverse Transcription PCR for Influenza A Virus, Influenza B Virus, and Severe Acute Respiratory Syndrome Coronavirus 2인플루엔자 A 바이러스, 인플루엔자 B 바이러스 및 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 다중 실시간 역전사 PCRResearch Published on 2021-07-012022-09-10 Journal: Emerging Infectious Diseases [Category] 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus disease acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus cause caused coronavirus coronavirus 2 coronavirus disease Coronaviruses COVID-19 Culture detect diagnostic differentiation drug Emergency use authorization Flu SC2 Multiplex food identify in vitro increase infectious dose Influenza influenza A influenza A virus influenza B influenza B virus Influenza virus influenza viruses multiplex Multiplex assay outbreak pandemic pathogen Pathogens PCR reaction real-time RT-PCR resources respiratory respiratory infections respiratory virus RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance Symptom tissue tissue culture US Food and Drug Administration virus viruses zoonoses [DOI] 10.3201/eid2707.210462 PMC 바로가기 [Article Type] Research