Congenital Infection of Severe Acute Respiratory Syndrome Coronavirus 2 With Intrauterine Fetal Death: A Clinicopathological Study With Molecular Analysis자궁 내 태아 사망을 동반한 중증 급성 호흡기 증후군 코로나바이러스 2의 선천적 감염: 분자 분석을 통한 임상병리학적 연구Case Reports Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis best Chain Reaction congenital congenital infection consequence coronavirus coronavirus 2 death demise described Diagnosis explained fetal fetal death fetal growth retardation fetus gestation growth growth retardation hemosiderosis hepatocellular histological Immunochemistry in utero in utero x death independent Infection knowledge lesions liver maternal-fetal transmission Mild miscarriage molecular mother Necrosis Neonatal observation observations occurred placental polymerase chain polymerase chain reaction polymerase chain reaction) Quantitative quantitative polymerase chain reaction respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection secondary to severe acute respiratory syndrome Coronavirus specimen symptomatic SARS-CoV-2 infection the SARS-CoV-2 genome tissue damage tissues Transmission variant vertical transmission virus visceral [DOI] 10.1093/cid/ciab840 PMC 바로가기 [Article Type] Case Reports
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations Research Published on 2022-08-222022-10-05 Journal: Nature Communications [Category] 바이오마커, 치료법, [키워드] acute phase reactant adverse outcome approach caused cellular change Co-regulation conditions COVID-19 death defined Elevation growth hospitalized patients Human Infection Inflammation Inflammatory Ischemia laboratory measurement linear mechanism Myocardial infarction pathologic Platelet Population provide risk Sepsis tissue damage trajectory trauma WBC White blood cell [DOI] 10.1038/s41467-022-32222-2 [Article Type] Research
Defining resistance and tolerance traits in Covid-19: towards a stratified medicine approachCovid-19의 내성 및 내성 특성 정의: 계층화된 의학 접근 방식Article Published on 2022-08-132022-09-11 Journal: QJM: An International Journal of Medicine [Category] SARS, 변종, [키워드] activated anti-Spike IgG approach Auto-antibodies CCR2 component coronavirus disease Coronavirus disease 2019 COVID-19 pathogenesis Deleterious failure Genetic Genetic variant genotypic GM-CSF heterogeneity highlight Highlights Host Host-directed therapies Human IFN-I IFN-α IFNA10 IFNAR2 IL-6 infection with SARS-CoV-2 Infectious disease inflammasomes inflammatory lung injury integration Inter-individual variation life-threatening coronavirus disease lung Lung injury M-CSF macrophages MCP-1 Monocyte-derived macrophages Monocytes neutralizing auto-antibodies neutralizing auto-antibody NLRP1 pathogen Pathogenesis periphery PLSCR1 pro-inflammatory pro-inflammatory response progression recruited reduce regulate response responses resulting reticuloendothelial system SARS-COV-2 infection stratified the disease therapeutic tissue damage Tolerance treatable TYK2 type 1 interferon virus-independent immunopathology [DOI] 10.1093/qjmed/hcac143 PMC 바로가기 [Article Type] Article
Cellular senescence and senolytics: the path to the clinic Reviews Published on 2022-08-112022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, 진단, 치료제, [키워드] alleviate Cell cell cycle arrest cellular senescence Clinical use condition deleterious effect disease Diseases disorder disorders drug humans Intervention Prevent Protein review secrete senescent cell shown therapeutic target tissue tissue damage [DOI] 10.1038/s41591-022-01923-y [Article Type] Reviews
SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다Article Published on 2022-08-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19 [DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational studyObservational Study Published on 2022-08-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age analysed approach association Characteristics clinical Clinical outcome clinical trials Cluster cluster analysis Clustering Clusters Cognitive impairment Cohort comparison Concentration COVID COVID-19 described discharge discharged domains effective Factor female full recovery Health hospital Hospital admission hospital discharge hospitalisation identify IL-6 improvement Inflammation Inflammatory inflammatory mediator Innovation Intervention Invasive mechanical ventilation ISRCTN registry less logistic regression modelling longitudinal cohort study median men mental health Mild moderate obesity Odds ratio organ function outcome measure outcome measures participant Participants Patient pharmacological PHOSP-COVID physical plasma Post-hospitalisation COVID-19 study potential therapeutic target profile proportion prospective observational study Protein Quality of life recruitment Registered reported retrospective severity Sex stratified tissue damage treatable utility was done was increased was performed was reduced were assessed WHO with COVID-19 women [DOI] 10.1016/S2213-2600(22)00127-8 PMC 바로가기 [Article Type] Observational Study
Molecular Mimicry, Hyperactive Immune System, And SARS-COV-2 Are Three Prerequisites of the Autoimmune Disease Triangle Following COVID-19 InfectionReview Published on 2022-08-012022-10-05 Journal: International immunopharmacology [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] adaptive antiviral immune response autoantibody Autoimmune Autoimmune disease Autoimmunity clinical manifestations COVID-19 COVID-19 vaccine COVID‐19 disease Diseases drug effective Host Hyperactive Immune System immune immune system immune systems include induce mimicry molecular mimicry pandemic Pathogenesis Patient purpura SARS-CoV-2 SARS-COV-2 infection self-tolerance susceptible patients Symptom syndrome System systemic Thyroid tissue damage Treatment Triangle variety virus [DOI] 10.1016/j.intimp.2022.109183 [Article Type] Review
Anti-Phospholipid Antibodies and Coronavirus Disease 2019: Vaccination Does Not Trigger Early Autoantibody Production in Healthcare Workers항인지질 항체 및 코로나바이러스 질병 2019: 예방접종은 의료 종사자의 조기 자가항체 생산을 유발하지 않습니다Article Published on 2022-07-152022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome adenovirus-based Anti-phospholipid antibodies antibody autoantibodies autoantibody autoimmune disorder Autoimmune response Autoimmunity BNT162b2 ChAdOx1 characteristic Cohort contribute contributing to coronavirus coronavirus disease COVID-19 cross-reactive dose elicit example Follow-up glycoprotein healthcare healthcare worker human protein IgA IgG IgM immunization Immunoglobulin immunothrombosis injection investigated Microarray molecular not affect Occurrence organ performed Production proteome reactivity reported RNA SARS-CoV-2 SARS-CoV-2 vaccination Support tested the disease thought tissue damage Trigger vaccination Vaccine Vaccines virus spike protein with COVID-19 worker [DOI] 10.3389/fimmu.2022.930074 PMC 바로가기 [Article Type] Article
Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19Review article Published on 2022-07-012022-10-05 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis [DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article
Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvementCOVID-19의 심장-폐 상호작용: 우심실 침범 모니터링을 위한 병상 심장 초음파의 예후 영향 및 유용성Review Published on 2022-07-012022-09-11 Journal: Heart failure reviews [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition adverse effect Afterload appear avoidance circulation Clinical deterioration contribute COVID-19 Critically ill critically ill patients dysfunction echocardiography extracorporeal membrane oxygenation facilitate heart heart failure Heart–lung interaction hemodynamic instability high mortality high risk hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hypoxemia IMPROVE increase in Interaction involved limit Limited management mechanical ventilation medication optimization outcome pathophysiologic Patient patient survival patients with COVID-19 pressure overload prognostic progression pulmonary pulmonary circulation pulmonary vascular resistance Pulmonary vessel thrombosis reducing Respiratory failure right heart failure right ventricle RV dysfunction SARS-COV-2 infection severe COVID-19 small vessel the SARS-CoV-2 thrombosis thrombotic thrombotic microangiopathy tissue damage transthoracic echocardiography Treatment TTE Vascular Vascular resistance ventricular vessel widespread [DOI] 10.1007/s10741-021-10108-7 PMC 바로가기 [Article Type] Review