Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study브라질에서 2회 용량 1차 프로토콜 및 BNT162b2 이종 부스터(Immunita-001)에서 비활성화된 바이러스(CoronaVac) 백신의 면역원성, 효과 및 안전성: 1년 기간의 후속 조치 4상 연구Clinical Trial Published on 2022-06-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody antibody levels Antibody titer Antibody titers approach association BNT162b2 booster booster dose Brazil Cellular immune response chemokines CoronaVac coronavirus COVID-19 COVID-19 pandemic Critical Cytokines Delta delta variant dose Effectiveness exposure to followed by growth factor Growth factors Heterologous heterologous booster highest IgG immune Immune profile immune response immunogenicity implication individual individuals Interaction maintenance male median mediators Neutralising Antibodies neutralising antibody no increase omicron Omicron variant pandemic Period phase 4 presenting protocol reduction remained respiratory restored robust Safe Safety SARS-CoV-2 Seropositivity severe acute respiratory syndrome Coronavirus significantly Spread timepoint titer titers vaccination Vaccine vaccine. variant virus Year [DOI] 10.3389/fimmu.2022.918896 PMC 바로가기 [Article Type] Clinical Trial
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2오미크론 특이적 mRNA 백신 단독 및 SARS-CoV-2에 대한 이종 부스터Article Published on 2022-06-062022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] animals Antibody Response assessment background level Beta binding antibody boost booster comparable delta variant elicit generate globe Heterologous homologous immune evasion in vivo increase injection LNP mice mRNA vaccination mRNA vaccine neutralization potency Neutralizing titer neutralizing titers omicron Omicron variant reduce reduction in responses against SARS-CoV SARS-CoV-2 These data titers vaccination Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41467-022-30878-4 PMC 바로가기 [Article Type] Article
Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies추가 백신 접종 및 단일 클론 항체에 의한 SARS-CoV-2 Omicron 변이체의 증강 중화Article Published on 2022-06-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody binding appearance approved binding BNT162b2 boost boost immunization candidate caused clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant determine dominant Effective vaccines Efficacy Evidence flow cytometry immunization increase MONITOR monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization assays neutralize neutralized Neutralizing neutralizing antibody omicron Omicron variant Omicron variants parental pathogenicity Protective pseudotyped SARS-CoV-2 recognize respiratory SARS-CoV-2 SARS-CoV-2 variants serum antibodies serum antibody serum titer serum titers severe acute respiratory syndrome Coronavirus Support therapeutic therapeutic antibodies titers Transmissibility vaccination vaccination. Vaccine variant variants virus variant virus variants Wuhan strain [DOI] 10.1002/eji.202249841 PMC 바로가기 [Article Type] Article
Oxidative stress and endogenous DNA damage in blood mononuclear cells may predict anti-SARS-CoV-2 antibody titers after vaccination in older adults혈액 단핵 세포의 산화 스트레스와 내인성 DNA 손상은 노인에서 예방 접종 후 항 SARS-CoV-2 항체 역가를 예측할 수 있습니다Article Published on 2022-06-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 치료기술, [키워드] age All participants anti-S anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibodies antibody Biomarker Biomarkers Blood BNT162b2 circulating correlated DNA DNA damage DNA damage response double-strand break DSBs Efficacy Efficiency first dose genomic humoral immune response Humoral response humoral responses Hypothesis IgG antibodies Immune cell immune cells immune senescence increase in Increased individual inverse correlation mononuclear cell mRNA vaccination mRNA vaccination. neutralizing capacity Older oxidative oxidative stress Participants Peripheral blood Peripheral blood mononuclear cells pre-vaccination predict SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 vaccination second dose Stress tested titers vaccination Vaccine vaccine efficacy [DOI] 10.1016/j.bbadis.2022.166393 PMC 바로가기 [Article Type] Article
Efficacy of antibody response following the vaccination of SARS-CoV-2 infected and noninfected healthcare workers by two-dose inactive vaccine against COVID-19COVID-19에 대한 2회 접종 불활성 백신에 의한 SARS-CoV-2 감염 및 비감염 의료 종사자의 백신 접종 후 항체 반응의 효능Article Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody Antibody Response Antibody responses appearance classical Comorbidities concerning coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Day demographics detect Efficacy first dose healthcare worker IgG antibodies IgG level IgG levels immunogenicity Immunosuppression inactive individuals infected with SARS-CoV-2 Infection information investigated majority Neutralizing activity positive postvaccination produced rapid increase SARS-CoV-2 screened second dose second vaccination seropositive seropositive individual seropositive individuals Seropositivity significantly higher Sinovac subject subjects Support Symptoms titers vaccination vaccination. Vaccine virus [DOI] 10.1002/jmv.27649 PMC 바로가기 [Article Type] Article
Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 중화와 비교한 항체 의존성 Fc 매개 바이러스 진입 평가Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody antibody dependent enhancement B.1.1.7 B.1.351 B.1.617.2 Beta characterization collected concern convalescent plasma coronavirus coronavirus – COVID-19 correlated Delta determine evaluated Fc-mediated virus entry functional Gamma HEK293 cell HEK293 cells IgM in vivo individuals infecting neutralization neutralization activity neutralization potency neutralization titer Neutralizing P.1 pandemic peaked plasma plasma dilution plasma IgG plasmas pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 strain SARS-CoV-2 variants significantly significantly higher significantly lower spike (S) protein titers variant Variant of concern. viral entry virus virus entry viruses VoC waned Washington while [DOI] 10.3389/fimmu.2022.901217 PMC 바로가기 [Article Type] Article
Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six MonthsSARS-CoV-2 변이체에 대한 BNT162b2 백신에 대한 체액 반응은 6개월 후 쇠퇴합니다.Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Against age age and gender Alpha Alter analyzed B.1 BNT162b2 BNT162b2 vaccine carried changes in Complete D614G decay decrease Delta determine Effectiveness evade evaluated Evidence FIVE Follow-up Gamma GraphPad humoral immune response immune escape mutation immune escape mutations immune response Immunity immunization immunogenicity individual men Month Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing capacity Neutralizing titer Older participant plaque reduction neutralization Prospective Study protocols raised reduction response SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants serum serum sample serum samples severity shown Support titer titers Transmissibility vaccination Vaccine variant Variant. variants Viral viral variant Viral variants was measured [DOI] 10.3389/fimmu.2022.879036 PMC 바로가기 [Article Type] Article
Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 VaccineBNT162b2 mRNA COVID-19 백신 2~3회 투여 후 SARS-CoV-2 변이체에 대한 중화 항체 반응 평가Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI Against age all age group all age groups assessment BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster vaccination cohort study conducted COVID-19 D614G variant delta variant dose group Immunity increase in induce Japanese Kobe lowest median age men Messenger RNA mRNA much higher Neutralizing antibodies neutralizing antibody Older age omicron Omicron variant other variant other variants outcome pandemic participant Participants physician Positive test positive test result recipient recipients response SARS-CoV-2 SARS-CoV-2 pandemic test results tested the SARS-CoV-2 the vaccine titer titers university vaccination Vaccine variant variants [DOI] 10.1001/jamanetworkopen.2022.10780 PMC 바로가기 [Article Type] Article
Fitness of B-Cell Responses to SARS-CoV-2 WT and Variants Up to One Year After Mild COVID-19 – A Comprehensive Analysis경증 COVID-19 이후 최대 1년까지 SARS-CoV-2 WT 및 변이체에 대한 B 세포 반응의 적합성 - 종합 분석Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation All participants Alpha Anti-RBD antibodies antibodies antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigen-specific memory B cells assays avidity B-cell binding binding antibodies binding antibody Comprehensive correlated COVID-19 declined Delta delta variant domain ELISA ELISPOT evaluate fitness Gamma IgA IgG memory B memory B cell memory B cells memory B-cell Mild N protein neutralization Neutralizing Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers nucleocapsid participant plasmablast plasmablast responses plasmablasts plasmablasts. post infection predicted Protein remained response SARS-CoV-2 SARS-CoV-2 specific memory B cells SARS-CoV-2 WT significantly increased symptomatic thiocyanate titers variant variants variants of concern waned were assessed were measured wild-type Year [DOI] 10.3389/fimmu.2022.841009 PMC 바로가기 [Article Type] Article
Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of COVID-19COVID-19의 B.1.617.2(델타) 변이형 소아 환자 66명의 임상적 특성 분석Article Published on 2022-05-012022-09-11 Journal: World Journal of Pediatrics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours accumulate acute respiratory syndrome acute respiratory syndrome coronavirus Admission age All the patient all the patients Analysis analyzed antibody B.1.617.2 B.1.617.2 (Delta) cardiac troponin Cardiac troponin I Characteristics children children with COVID-19 clinical Clinical characteristics clinical experience Clinical features clinical symptom Clinical symptoms Cluster coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19). COVID-19 Cycle threshold value Cycle threshold values D-dimer Delta description disease onset erythrocyte sedimentation erythrocyte sedimentation rate evaluate Frame Gender Genome gradually increased group help hospital IgG IgM IgM antibodies IgM antibody Immunoglobulin Incubation period laboratory data medical staff Mild moderate nucleocapsid protein Open reading frame open reading frame 1 Pediatric patient positive respiratory sedimentation rate severe acute respiratory syndrome Coronavirus statistically significant difference Symptom tested titers troponin I variant [DOI] 10.1007/s12519-022-00529-1 PMC 바로가기 [Article Type] Article