TMPRSS2 protease – Page 2 – Communicable Diseases Research

Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2

Review

Published on 2021-03-182022-10-04
Journal: Journal of medical virology
[Category] SARS, 유전자 메커니즘,

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19

Research article

Published on 2021-01-282022-10-05
Journal: Heliyon
[Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 variant activate activating African aggressiveness binding caused cell receptor correlation COVID-19 COVID-19 infection COVID-19 pandemic Deleterious East Asian ENhance eQTLs European European populations explain facilitate furin FURIN gene Genes Genetic variation Genomic medicine highlight human cells individual investigated Iran Kuwait middle Middle Eastern populations mortality rate Population populations Precision precision medicine predictor RBD S-protein SARS-CoV-2 sequence severity structural evidence the SARS-CoV-2 the SARS-CoV-2 virus TMPRSS2 TMPRSS2 protease variant variants Variation viral entry
[DOI] 10.1016/j.heliyon.2021.e06133 [Article Type] Research article

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

SARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다

Research Article

Published on 2021-01-252022-08-13
Journal: PLoS Pathogens
[Category] COVID-19, Medicine and Health Sciences,

[키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion
[DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study

ACE2 유전적 다형성의 영향을 받는 SARS-CoV-2 감염 감수성: 테헤란 심장 대사 유전 연구의 통찰력

Article

Published on 2021-01-152022-09-01
Journal: Scientific Reports
[Category] 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] 3D structure 3D Structures ACE2 ACE2 gene ACE2 variation affecting affinity bioinformatics cleavage contribute COVID-19 pandemic Critical disease severity docking drug drug response explain Factor Genetic genetic study Genetic variation Genetic variations genotyping INDEL individual insertion/deletion interactions investigated life Missense Molecular modelling notable nucleotide Participants Pathogenesis pathogenesis of COVID-19 pathway Pathways Personalized medicine protease Protein receptor reduce reported SARS-CoV-2 SARS-COV-2 infection Single nucleotide polymorphism single nucleotide polymorphisms SNP spike Spike protein susceptibility Tehran TMPRSS2 TMPRSS2 protease Vaccines variants Viral viral spike protein whole-genome sequencing
[DOI] 10.1038/s41598-020-80325-x PMC 바로가기 [Article Type] Article

Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity

Microbiology

Published on 2020-11-232022-10-31
Journal: Frontiers in Microbiology
[Category] COVID-19,

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection

Priority Research Paper

Published on 2020-11-172022-10-28
Journal: Oncotarget
[Category] COVID-19,

[키워드] ACE2 ACE2 expression ACE2 mRNA Affect airway epithelial cells antiviral agent attenuate bronchial epithelial cells Cell cells cellular COVID-19 COVID-19 severity cytokine cytotoxicity Disease progression elevated expression G-CSF human cells IL-1α IL-6 immune response in some increase individual Inflammatory cytokine inflammatory cytokines IL-6 inhibit killing lentiviral lung cancer M-CSF MAPK MCP-1 MEK inhibitor natural NK cells NK-cell observed correlation pathway Patient Patients with cancer plasma Population pRB proliferative promote Protein pseudovirus pseudovirus infection reduce Regulation Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-S stimulate stimulated suppress suppressed TMPRSS2 TMPRSS2 protease TRAIL treated
[DOI] 10.18632/oncotarget.27799 PMC 바로가기 [Article Type] Priority Research Paper

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

Research

Published on 2020-09-232022-10-29
Journal: Journal of Experimental & Clinical Cancer Research : CR
[Category] COVID-19, SARS,

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping

Review

Published on 2020-06-102022-10-29
Journal: Journal of Inflammation (London, England)
[Category] COVID-19,

[키워드] ACE2 Activation age angiotensin-converting enzyme 2 caused condition COVID-19 COVID-19 infection COVID-19 patients COVID-19 susceptibility Cytokine storm develop diabetes disease E-cigarettes effective therapy engulfment epithelial permeability Future globe GM-CSF high affinity hypertension IFN-γ IL-2 IL-6 IL-7 immune responses Inflammation inflammatory storm IP-10 lung lung epithelium MCP-3 membrane morbidity and mortality Mortality outcome pandemic of COVID-19 pro-inflammatory Proteases provide receptor Research response S1 domain SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe disease shown smoking target the SARS-CoV-2 therapy TMPRSS2 protease TNF-α vaping viral entry
[DOI] 10.1186/s12950-020-00250-8 PMC 바로가기 [Article Type] Review

The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies

IM-Point of view

Published on 2020-05-192022-10-30
Journal: Internal and Emergency Medicine
[Category] COVID-19, MERS, SARS,

[키워드] “cytokine storm” ACE-2 ACE-inhibitors angiotensin II receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB ARBs benefit binding blocker cardiovascular comorbidity cardiovascular disease cardiovascular diseases Cell cell types characterized China chromosome claimed Clinical course Clinical practice coding COVID-19 Deceased diabete disease Disseminated intravascular coagulation downregulation drugs Effect Effects Endothelial cell endothelial cells Endothelium enzyme epidemiological situation Evidence experimental model expressed expression female patient hazard host’s cell humans hypertension implication in vivo Infection intestinal involved Italian kidney molecular Mortality most prevalent comorbidity mRNA Neutral Occurrence Older Patient patients treated patients with COVID-19 Prospective Study protein level question Randomized receptor renal reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2-infected patients smoking Spike protein subsequent targets therapy Thromboembolism thrombosis tissues TMPRSS2 protease treated Treatment Vasculitis worse prognosis
[DOI] 10.1007/s11739-020-02364-6 PMC 바로가기 [Article Type] IM-Point of view