Toxin-like peptides in plasma, urine and faecal samples from COVID-19 patientsCOVID-19 환자의 혈장, 소변 및 대변 샘플의 독소 유사 펩타이드Research Article Published on 2021-10-142022-09-11 Journal: F1000Research [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] affecting animals can not clinical manifestations clinical symptom Clinical symptoms cloud component COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients disorder Evidence evidence of excluded faece Faeces heterogeneous human genes Infection infection mechanism involved Liquid chromatography manifestation mass spectrometry molecular weight neurological manifestations opens pandemic peptide peptides performed persistence phospholipases plasma reported SARS-CoV-2 SARS-COV-2 infection selective severity Symptom the disease toxin toxin-like peptides transcript transcripts Urine Zinc [DOI] 10.12688/f1000research.54306.2 PMC 바로가기 [Article Type] Research Article
The effect of hemoperfusion on the outcome, clinical and laboratory findings of patients with severe COVID-19: a retrospective studyOriginal Article Published on 2021-09-022022-10-30 Journal: New Microbes and New Infections [Category] COVID-19, [키워드] addition analysed antiviral therapies Blood collected control group coronavirus disease COVID-19 CRP demographic distress evaluate the effect Hemoperfusion Hospital stay ICU IMPROVE Inflammatory factor inflammatory factors intensive care Laboratory Mortality outcome participated Pathogenesis Patient positive PCR test reduce Retrospective study SARS-CoV-2 severe COVID-19 significant decrease significant increase SpO2 toxin treated Treatment Treatment protocol was performed [DOI] 10.1016/j.nmni.2021.100937 PMC 바로가기 [Article Type] Original Article
Botulinum Toxin Services for Neurorehabiliation: Recommendations for Challenges and Opportunities during the COVID-19 PandemicCommunication Published on 2021-08-222022-10-28 Journal: Toxins [Category] COVID-19, MERS, SARS, [키워드] adopted Botulinum toxin challenge Clinical practice condition COVID-19 COVID-19 crisis COVID-19 pandemic dystonia Effectiveness European country Guidance Health impacted muscle spasticity opportunity pandemic Patient Patient care platform recommendation rehabilitation risk service sialorrhea supported therapy toxin Treatment urgency [DOI] 10.3390/toxins13080584 PMC 바로가기 [Article Type] Communication
A model of the innate immune response to SARS-CoV-2 in the alveolar epitheliumMathematics Published on 2021-08-112022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] ACE2 expression alveolar epithelial cells alveolar epithelium antiviral therapy basic reproductive number benefit binding affinity Cell chemokines Control Course deleterious effect determinant epithelial exacerbate host response Impact individual variation Infection Innate immune cells innate immune response interferon interferons Model moderate parameters predicted Prognosis reduce robust SARS-CoV-2 SARS-CoV-2 spike protein significantly suppresse Therapies therapy tissue damage toxin type I Variability viral dynamics Viral load while within-host [DOI] 10.1098/rsos.210090 PMC 바로가기 [Article Type] Mathematics
Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin ConditionsOriginal Research Reports Published on 2021-08-012022-10-28 Journal: Stem cells and development [Category] COVID-19, MERS, SARS, [키워드] addition approach Calu-3 calu-3 cells chronic inflammation Comorbidity Concentration condition contribute contributed contributing to correlation COVID-19 COVID-19 patient Cytokine storm Diabetes Mellitus disease DM downregulation effort epithelial cell examined extracellular vesicle Extracellular vesicles Factor function Glucose human lung Jelly Meta-analysis Mortality MSCs NF-κB nuclear Organ failure outcome p65 Patient patients with COVID-19 Potential treatment RD reaction reduce renal Research SARS-CoV SARS-CoV-2 severe symptom severity of COVID-19 significant decrease STEM stem cell suggested systematic review the cytokine storm toxin toxins uremic viral infection was increased [DOI] 10.1089/scd.2021.0065 PMC 바로가기 [Article Type] Original Research Reports
Critical illness-associated cerebral microbleeds for patients with severe COVID-19: etiologic hypotheses중증 COVID-19 환자의 중병 관련 뇌 미세 출혈: 병인 가설Article Published on 2021-08-012022-09-11 Journal: Journal of Neurology [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Atypical blood-brain barrier Brain brain MRI Concentration control patient COVID-19 COVID-19 infections COVID-19 outbreak creatinine Critical Critical illness D-dimers described dialysis dysfunction Endotracheal intubation extracorporeal membrane oxygenation Hemorrhagic hypothese Hypothesis Hypoxemia ICU intensive care unit intensive care units introduced kidney Kidney failure manifestation mechanism microangiopathy Microhemorrhages. MRI neurologic Patient patients respiratory distress Respiratory distress syndrome Respiratory failure secondary to Severe COVID-19 Infection severe COVID-19 infections severe COVID-19 patients syndrome tendency tested thrombotic thrombotic event toxin university uremic was performed White matter with COVID-19 [DOI] 10.1007/s00415-020-10313-8 PMC 바로가기 [Article Type] Article
Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy진단 및 치료를 위한 감염성 질환 및 독소에 대한 파지 디스플레이에 의한 재조합 항체 개발Review Published on 2021-07-072022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] Against antibodies antibody antibody fragment Autoimmune diseases Bacterial Cancer caused convalescent patient COVID-19 pandemic Developing Diagnosis diagnostic disease Diseases display DNA sequence eukaryotic Final human monoclonal antibodies immune immune systems in vitro in vivo Infectious disease limitation microbial monoclonal antibody packaged Particles pathogen Pathogens phage phage display recombinant recombinant antibodies scFv antibodies selected sera therapeutic therapy toxin toxins treat Treatment VHH antibodies while [DOI] 10.3389/fcimb.2021.697876 PMC 바로가기 [Article Type] Review
Geographical Detector-Based Spatial Modeling of the COVID-19 Mortality Rate in the Continental United StatesArticle Published on 2021-06-252022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Asian black cause collected Comorbidity complex COVID-19 COVID-19 epidemic COVID-19 mortality death case death rate Detector determinant disease distribution ecological Effect Epidemic examined Factor Factors geographical detector Government Health help Hispanic impact factor individual individual effects individuals Interaction interaction effect interactive effect investigated joint modeling Mortality MOST potential risk provided Rate recommendation Research response responsible risk risk factor smoking Spatial distribution temperature toxin United State United States variables white with COVID-19 [DOI] 10.3390/ijerph18136832 PMC 바로가기 [Article Type] Article
Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering장내 Bacteroidales의 이동형 VI 분비 시스템 유전자좌는 광범위한 생태계 내 이동, 다종 확산 및 지리적 클러스터링을 나타냅니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Analysis Bacterial Bacteroidale Bacteroidales benefit Clustering Community competitive advantage comprehensive analysis conjugation demonstrated dissemination distribution ecological Ecology element Evolution evolutionary dynamics exclusion expected fitness fixation Genes Genetic genetic architecture Genome genomes genomic globe Gut gut microbiota human population human populations identify Impact loci metagenomic metagenomic analyses microbial microbial ecosystem Microbiome Mobile multi neighboring cell neighboring cells observation phenotype Phenotypes Prevalence Recombination secretion species Spread strain Subtypes These data toxin toxins transfer transferred tRNA Type [DOI] 10.1371/journal.pgen.1009541 PMC 바로가기 [Article Type] Research Article
An Overview of Nanocarrier-Based Adjuvants for Vaccine DeliveryReview Published on 2021-03-272022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] adjuvant adjuvants Antigen contributing to delivery Disadvantages Diseases effective delivery immune response immunostimulatory inactivated induce Infection long-lasting memory response Nanocarriers Nanotechnology non-viral vectors parameter pathogen pattern recognition receptor phosphate PROTECT receptor receptors robust sustained toxin vaccination Vaccine vaccine delivery systems Vaccines vector viral vectors Virus-like particle whole organism [DOI] 10.3390/pharmaceutics13040455 PMC 바로가기 [Article Type] Review