Trachea – Page 2 – Communicable Diseases Research

Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease

Article

Published on 2022-01-192022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus,

The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection

Felids의 상부 호흡기는 SARS-CoV-2 감염에 매우 취약합니다

Article

Published on 2021-09-302022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술,

Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Article

Published on 2021-09-282023-06-15
Journal: Cell Reports Medicine [Category] MERS, SARS,

[키워드] ACE2 ciliated epithelial cell COVID-19 IFN-β1 Nasal cavity SARS-CoV-2 smoking TMPRSS2 Trachea upper airway
[DOI] 10.1016/j.xcrm.2021.100421 PMC 바로가기 [Article Type] Article

Ultra- and micro-structural changes of respiratory tracts in SARS-CoV-2 infected Syrian hamsters

SARS-COV-2 감염 시리아 햄스터에서 호흡기의 초소형 및 미세 구조적 변화

Research Article

Published on 2021-09-162022-09-10
Journal: Veterinary Research [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar alveolar epithelium alveoli animal models Bronchiole caused cellular change changes in Characteristics collected coronavirus cytoplasm cytoplasmic diminished disease electron eosinophil eosinophils epithelial euthanized groups hamster increasingly infancy inflammatory cell inflammatory cells information inoculated intranasally lamina propria lesion lesions Lower respiratory tract lung Lymphocytes macrophages margin Microscopic neutrophil Neutrophils nucleus on type organelle pandemic Particles pathological changes Post-infection pulmonary lesions PULMONARY VESSELS Research respiratory respiratory epithelium respiratory tract SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus susceptible therapy tissue tissues Trachea tracheal type 2 pneumocyte upper and lower respiratory tracts Vaccine vacuolation Vesicle vessels Viral virion
[DOI] 10.1186/s13567-021-00988-w PMC 바로가기 [Article Type] Research Article

Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α

사이토카인 폭풍과 COVID-19 관련 사망 사례 60건의 조직병리학적 발견: 바이러스 부하 연구에서 주요 선수 IL-1β, IL-6, IL-15 및 TNF-α의 면역조직화학적 정량화에 이르기까지

Original Article

Published on 2021-08-312022-09-11
Journal: Forensic Science, Medicine, and Pathology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome alveolar capillary antibody ARDS Autopsies Autopsy CD20 CD4 CD45 CD8 Cell collected control group COVID-19 COVID-19 group COVID-19 related-death current cytokine Cytokine storm Cytokines death Endothelial cell endothelial cells evaluate Evidence expressed expression fibrinogen histological analysis histopathological finding Hypothesis IL-10 IL-15 IL-1β IL-6 immunohistochemical staining immunohistochemistry immunoreactivity inflammatory cell inflammatory cells Inflammatory cytokine lung MCP-1 multiple cytokine multiple cytokines multiple organ failure nasopharynx nucleoprotein organs oropharynx outcomes overexpression Pneumonia positive Proinflammatory cytokine proinflammatory cytokines quantification Research respiratory respiratory distress RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR selected Spike protein Swab swabs syndrome T cells tested the spike protein tissue TNF-α Trachea Viral load virus
[DOI] 10.1007/s12024-021-00414-9 PMC 바로가기 [Article Type] Original Article

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis

시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입

Immunology

Published on 2021-08-242022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used
[DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology

Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice

K18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과

Article

Published on 2021-08-202022-08-31
Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제,

[키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected
[DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients

COVID-19 환자의 부검에서 SARS-CoV-2의 다중 전신 세포 친화성

Article

Published on 2021-07-272022-09-11
Journal: Cells [Category] SARS, 치료기술,

[키워드] ACE2 adrenal gland alteration analyzed assigned Autopsies Autopsy bowel Cell Chain Reaction correlation COVID-19 COVID-19 autopsy sample electron microscopy endothelial cells epithelial epithelial cell epithelial cells expressing fatal COVID-19 FFPE formalin formalin-fixed paraffin-embedded formalin-fixed paraffin-embedded (FFPE) tissue heart histology histopathological immunohistochemistry In situ hybridization Infection kidney liver lung lymph nodes major organs Microscopy organ systems organs oropharynx paraffin polymerase chain polymerase chain reaction Post-mortem Prostate Replication respiratory respiratory tract RNA salivary glands SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 RNA shown Skeletal muscle skin the SARS-CoV-2 Thyroid TMPRSS2 tonsils Trachea transmission electron microscopy tropism tropism of SARS-CoV-2 Viral Viral detection Viral protein Viral RNA virus particle virus particles
[DOI] 10.3390/cells10081900 PMC 바로가기 [Article Type] Article

Differential susceptibility of SARS‐CoV‐2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation

동물에서 SARS-CoV-2의 감수성: 면역조직화학적 특성화에 의한 반려동물, 가축 및 야생동물에서 ACE2 숙주 수용체 분포의 증거

Original Article

Published on 2021-07-262022-09-10
Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 치료기술,

[키워드] absence ACE2 ACE2 expression Acinonyx addition anatomical angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding bronchiolar cats cattle characterisation cheetah coronavirus distribution Enterocyte enterocytes enzyme Eptesicus European badger Evidence evidence of felids Felis ferret ferrets gastrointestinal tracts histological Host host cell host cell membrane host receptor host susceptibility humans IHC immunohistochemistry in some indicated information intestine limit lion Lower respiratory tract lung Lungs Mesocricetus microvillus mink mustelids nasal nasal mucosa nasal turbinate Neovison Ovis primates Protein receptor respiratory respiratory and gastrointestinal tracts respiratory tract respiratory tracts SARS Coronavirus SARS coronaviruses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serotine bat sheep species susceptibility tiger tissue tissue tropism Trachea Viral viral infection zoonoses
[DOI] 10.1111/tbed.14232 PMC 바로가기 [Article Type] Original Article

Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

COVID-19 골든 시리아 햄스터 모델에서 폐 영상 및 SARS-CoV-2 항체 반응의 성별 차이

Research Article

Published on 2021-07-132022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alter animal animal model animal models body mass cause caused causes Chest computed tomography comparable Computed tomography concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cytokine deaths difference dose estradiol euthanized female females greater hamster Hospitalization hospitalizations human population IFN-β IgA response IgA responses IgG IgG antibodies IgG antibody IgM imaging Infection Infectious virus infective Infective dose inoculated interferon intranasally Lungs male Model morbidity Mortality mounted mutant nasal turbinates outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 plasma Pneumonia pulmonary damage RBDs Receptor-binding domain reported respiratory respiratory tissues response S-RBD SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Sex difference sex differences significantly Spike protein TCID the receptor-binding domain the spike protein tissue tissue culture TNF-α Trachea Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α virus virus titers virus-neutralizing antibodies virus-neutralizing antibody
[DOI] 10.1128/mBio.00974-21 PMC 바로가기 [Article Type] Research Article