Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination백신 접종으로 유도된 오미크론 포함 SARS-CoV-2 변이체에 대한 광범위 중화 항체Article Published on 2022-04-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Adenovirus Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies Antibody Response Beta binding broad spectrum Complete complex COVID-19 vaccine Cryo-electron microscopy defined Delta demonstrated develop drug elicited epitope exhibited Gamma hACE2 highlighting Infection investigated K18-hACE2 mAb monoclonal antibody nCoV neutralization neutralizing antibody omicron other variant other variants Prophylactic Protein Protein binding provided Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the RBD the spike protein therapeutic Transgenic mouse vaccination Vaccines variant VOCs [DOI] 10.1038/s41392-022-00987-z PMC 바로가기 [Article Type] Article
Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic MiceK18-hACE2 형질전환 마우스에서 우려되는 알파, 베타 및 델타 SARS-CoV-2 변이체에 대한 항체 매개 보호 평가Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] Alpha Alpha VOC angiotensin angiotensin converting enzyme Beta Brain can be used concern convalescent convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patient Critically ill decrease Delta Delta VOC disease dose Efficacy elevated enzyme evaluate Evaluating hACE2 hcp Human IgG titer immune evasion immunization in vivo model K18 K18-hACE2 K18-hACE2 transgenic mice lethality lung Mediated mice modeling modeling COVID-19 monoclonal antibody Mortality not decreased nucleocapsid nucleocapsid IgG pandemic passive immunity passive immunization polyclonal antibodies polyclonal antibody problem protection RBD Receptor binding domain response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum single dose Strains survival These data transgenic Transgenic mouse Treatment treatment group Vaccine variants variants of concern variants of concern. Viral Viral RNA while [DOI] 10.1128/jvi.02184-21 PMC 바로가기 [Article Type] Article
Multicolor strategies for investigating clonal expansion and tissue plasticityReview Published on 2022-02-202023-08-30 Journal: Cellular and Molecular Life Sciences [Category] E형 간염, [키워드] Brain Fluorescent reporters lineage tracing morphogenesis Multichannel imaging Transgenic mouse [DOI] 10.1007/s00018-021-04077-1 PMC 바로가기 [Article Type] Review
Delayed Antiviral Immune Responses in Severe Acute Respiratory Syndrome Coronavirus Infected Pregnant MiceMicrobiology Published on 2022-01-212022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 Activation acute respiratory syndrome antibody antibody production Antibody titers cause CD8 coronavirus coronavirus disease correlated Course COVID-19 Delayed elevated examined expression Fertility IgM immune response immune responses in viral Infection interfere lung marker mice Mortality non-pregnant female occur Post-infection Pregnancy pregnant Proinflammatory cytokine proinflammatory cytokines remained reported respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2-specific IgG serum Symptom T cell T cell activation the disease the SARS-CoV-2 virus Transgenic mouse Transmission Viral load viral loads were infected [DOI] 10.3389/fmicb.2021.806902 PMC 바로가기 [Article Type] Microbiology
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo이중특이성 단량체 나노바디는 스파이크 삼량체 이량체를 유도하고 생체 내에서 SARS-CoV-2를 중화합니다Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies binding Antiviral Beta Beta variant binding coronavirus cross-neutralize Delta variants elicited host cell host cell receptor human ACE2 in vivo inactivation induce inhibit interact Isolation mechanisms mice monomeric nanobody neutralization neutralize RBD RBDs respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike trimer therapeutic Therapeutic molecule therapeutic molecules therapeutic potential Transgenic mouse Trimers variant variants variants of concern Viral Viral antigen viral antigens viral infection virus [DOI] 10.1038/s41467-021-27610-z PMC 바로가기 [Article Type] Article
Experimental Models of COVID-19COVID-19의 실험 모델Review Published on 2022-01-052022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, [키워드] in vitro model ACE2 receptor African African green monkeys animal model animal models balancing biosafety level cell line contribute COVID-19 COVID-19 disease different cell different cells Epidemic experimental models of COVID-19 ferret green hamster Hepatitis Human human populations humanized immortalized In-vitro Infection Laboratory level 3 macaques mechanism MHV-1 mice mimicking Model mouse mouse hepatitis murine hepatitis virus NHPs non-human primates pandemic pathology Pneumonia Prevent primate receptor receptors Replication Research rhesus macaques robustness SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Scientific community Spectrum susceptible therapy Transgenic mouse Transmission transmitted treat variants of concern Viral viral infection virus [DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review
Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues자가포식 억제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스 및 이종이식 인간 폐 조직에서 폐렴을 개선합니다Article Published on 2021-11-232022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] 3-MA accompanied Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin animal model animal models anti-SARS-CoV-2 therapeutics Atg13 ATG14 Atg5 autophagic autophagy autophagy-inhibiting agent autophagy-inhibiting agents autophagy. block caused Combination complex Complexes contribute coronavirus Crab-eating macaque Critical elements enzyme events experimental evidence global pandemic hACE2 Huh-7 cells Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung human lung tissue IMPROVE in vitro in vivo induce Infection inhibit inhibition insight interfere involved mechanism mice modulation mouse mTOR pathway Pneumonia potential therapeutic target potential therapeutic targets SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppresse therapeutic agent therapeutic agents thought tissues transgenic mice Transgenic mouse Vero E6 virus infection Virus-host interaction Virus-host interactions Vps34 [DOI] 10.1128/JVI.01537-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strainsSARS-CoV-2 B.1.1.7(알파) 및 B.1.351(베타) 변이체는 초기 균주와 구별되는 K18-hACE2 형질전환 마우스에서 병원성 패턴을 유도합니다Article Published on 2021-11-122022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta Adaptive immunity Alpha Antibody neutralization Antimicrobial responses B.1.1.7 B.1.351 caused combating COVID-19 cytokine D-dimer death hACE2 help hypoxia Immunity immunization induce Infection intramuscular K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice lesion less medical intervention mice Mutant SARS-CoV-2 neutralization titer organ pathogenic pathology Receptor binding domain reduced Reinfection resulting SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants Signaling strain Strains Transgenic mouse Transmissibility variant variants variants of concern Viral viral infection viral spike virulence VoC VOCs [DOI] 10.1038/s41467-021-26803-w PMC 바로가기 [Article Type] Article
564. SARS-CoV-2 Ferritin Nanoparticle Vaccines Elicit Broad SARS Coronavirus ImmunogenicityPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] analyzed antibody antigenic approach binding breadth clinical trial Combination domain elicit elicited Emergency use authorization global pandemic Heterologous High-dose highlight immune response immunization immunogen immunogenicity K18-ACE2 K18-hACE2 mice Multiple murine mutations N-terminal domain nanoparticle neutralization Neutralizing NTD observation pandemic platform prefusion pseudovirus RBD reported responses Result robust SARS-CoV RBD SARS-CoV-1 SARS-CoV-1 RBD SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2 virus variant SARS-like coronavirus sera spike the SARS-CoV-2 transfused transgenic mice Transgenic mouse Vaccine Vaccine design vaccine platform variant variants of concern virus were assessed zoonotic [DOI] 10.1093/ofid/ofab466.762 PMC 바로가기 [Article Type] Poster Abstracts
In Vivo Mouse Models for Hepatitis B Virus Infection and Their ApplicationReview Published on 2021-10-292023-06-03 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus Hydrodynamic injection liver humanized mouse Transgenic mouse Viral vector [DOI] 10.3389/fimmu.2021.766534 PMC 바로가기 [Article Type] Review