On the Parametrization of Epidemiologic Models-Lessons from Modelling COVID-19 Epidemic전염병 모델의 매개변수화 - COVID-19 전염병 모델링의 교훈Article Published on 2022-07-022022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] applied approach Bayesian Bayesian knowledge synthesis biases conditions country Course COVID-19 COVID-19 epidemiologic models data sets Effectiveness estimates extended multi-compartment SIR-type model Germany hidden include information input-output non-linear dynamical system Intervention knowledge Numerous Observable Observational data parameter parametrization. past Reporting SARS-CoV-2 pandemic synthesis the epidemic translated Unknown vaccination virus variants [DOI] 10.3390/v14071468 PMC 바로가기 [Article Type] Article
More questions than answers for the use of inhaled nitric oxide in COVID-19Review article Published on 2022-07-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] 바이오마커, 임상, 치료제, [키워드] acute respiratory distress administration anti-inflammatory actions antiviral properties approved ARDS bloodstream clinical outcomes Cohort studies coronavirus disease COVID-19 Factor Hypoxemia IMPROVE improvements in oxygenation inactivation Inhaled lung mechanisms Neonates nitric oxide off-label Oxygenation pathological conditions patient selection patients with COVID-19 Potential treatment pulmonary hypertension question Randomized Randomized controlled trial Respiratory failure retrospective SARS-CoV-2 syndrome systemic effect therapy translated Treatment variety Vascular Ventilated [DOI] 10.1016/j.niox.2022.05.001 [Article Type] Review article
A Game of Infection – Song of Respiratory Viruses and Interferons감염의 게임 - 호흡기 바이러스와 인터페론의 노래Review Published on 2022-06-292022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 coronavirus disease acute respiratory syndrome Antiviral Antiviral strategies antiviral strategy cause caused coronavirus coronavirus – COVID-19 coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic CoVs death deaths disease pathogenesis driving effective flu game Health Host Host immune response host immune responses immune responses Infection Influenza influenza A influenza A virus influenza virus influenza viruses innate immune innate immune response innate immune responses innate immune system Innate immunity mechanism outcome pandemic Pandemics pathogen Pathogenesis Pathogens recorded Research respiratory SARS-CoV-2 Severe acute respiratory syndrome singular Song Spanish flu swine flu therapeutic Topic translated virus virus infection virus infection. Virus-host interaction Virus-host interactions while writing [DOI] 10.3389/fcimb.2022.937460 PMC 바로가기 [Article Type] Review
The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune GenesSARS-CoV-2에 감염된 세포의 번역 환경은 선천 면역 유전자의 억제를 나타냅니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus Air-liquid interface airway Cell cell cultures cell line cells cellular cellular mRNAs chemokine ciliated ciliated cell coding coronavirus cytokine downregulation event help highlight host mRNA host response host responses immune immune response immune responses infected cells Inflammatory Innate innate immune innate immune response Interaction interferon-stimulated genes involved landscape mechanism mediators modulate mRNA mRNA translation mRNAs notable primary cells programmed frameshifting regulated respiratory ribo-seq ribosomal frameshifting ribosome ribosome profiling ribosomes RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppression therapeutic therapeutic intervention These data transcriptional Transcriptional upregulation translated translation translation initiation translational translational repression unique upregulation Viral viral mRNA viral mRNAs virus virus replication virus-host interaction. [DOI] 10.1128/mbio.00815-22 PMC 바로가기 [Article Type] Article
Lockdown surgery: the impact of coronavirus disease 2019 measures on cardiac casesObservational Study Published on 2022-06-152022-10-04 Journal: Interactive cardiovascular and thoracic surgery [Category] Coronavirus, COVID19(2023년), SARS, 임상, [키워드] analysed Analysis cardiac Cardiac surgery Care Characteristics collected conducted coronavirus disease COVID-19 cross-sectional demographics Department equipment health condition Intervention lockdown management measure mitral no difference outcome outcomes pandemic Pandemics Patient patient selection remained SARS-CoV-2 SARS-CoV-2. significant decrease significantly surgery surgical Surgical Procedure symptomatic translated university urgency [DOI] 10.1093/icvts/ivac060 PMC 바로가기 [Article Type] Observational Study
The role of community leaders and other information intermediaries during the COVID-19 pandemic: insights from the multicultural sector in Australia Research Published on 2022-05-172022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료법, [키워드] activities agency blocked Community COVID-19 ENhance Government Health idea individuals information limitation pandemic Pandemics participant provided public health public health communication raised resource Support translated [DOI] 10.1057/s41599-022-01196-3 [Article Type] Research
A machine learning approach to predict resilience and sickness absence in the healthcare workforce during the COVID-19 pandemicCOVID-19 전염병 동안 의료 인력의 회복력 및 질병 부재를 예측하는 기계 학습 접근 방식Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Accuracy approach BAC city Consequences COVID-19 pandemic COVID-19-related distress distress Early detection evaluated Evidence explain Finnish Follow-up Generalizability HCW HCWs healthcare healthcare worker Healthcare workers Helsinki hospital independent individual Kymenlaakso Mental disorder Mental Disorders pandemic personal health predict Predictive Probability prognostic psychological resilience Resilience risk service shown Sickness sickness absence targeted interventions translated university [DOI] 10.1038/s41598-022-12107-6 PMC 바로가기 [Article Type] Article
Impact of an Immune Modulator Mycobacterium-w on Adaptive Natural Killer Cells and Protection Against COVID-19면역 조절제 Mycobacterium-w가 적응성 자연 살해 세포 및 COVID-19에 대한 보호에 미치는 영향Article Published on 2022-05-042022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive adaptive NK cells ADCC administration Against antibody-dependent cellular cytotoxicity baseline both groups Cell Cohort control group correlated COVID-19 downregulation expression healthcare worker high-risk population IFN-γ Impact incidence inhibitory Innate immunity innate immunity. modulator Mw for COVID-19 Mycobacterium w (Mw) Mycobacterium natural natural killer NKG2A NKG2C non-immune pathway Pathways protection provided reduction in risk RNA-seq analysis SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 translated upregulation Virus Disease [DOI] 10.3389/fimmu.2022.887230 PMC 바로가기 [Article Type] Article
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19QSAR, 분자 도킹, 분자 동적 시뮬레이션 및 MM-PBSA의 조합: COVID-19에 대한 잠재적 약물 후보로서 로피나비르 및 파비피라비르의 유사체Article Published on 2022-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption active site analogue analysis anti-viral drug Anti-viral drugs binding affinity candidate Candidates Compound COVID-19 COVID-19 infection COVID-19 infections demonstrated disease distribution docked complex docking drug candidate druggability effective enzyme Enzymes Favipiravir feature form identify IMPROVE in vitro inhibit Interaction less Lopinavir M pro metabolism Modification molecular molecular docking molecular dynamic simulations molecular dynamics Molecular dynamics simulation novel drug physicochemical polyprotein polyproteins processing protease Protease. QSAR Quantitative RdRP Replication residue RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selected shown significantly small molecule Small molecules Spread stable complex Toxicity trajectory translated Treatment Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1080/07391102.2020.1850355 PMC 바로가기 [Article Type] Article
Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19COVID-19 진단 및 예후를 위한 실험실 바이오마커Review Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] Admission Analysis aspartate Aspartate transaminase AST Biomarker Biomarkers BNP Brain brain natriuretic peptide cause clinical manifestations Clinical practice coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase Cytokines D-dimer Diagnosis diagnostic disease severity focus Future Hospitalization ICU identify include Inflammation intensive care intensive care unit laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH Lymphocytes metabolomic metabolomics Mortality multiorgan failure Myoglobin N-terminal Neuron-specific enolase neutrophil neutrophil count Neutrophils NT-proBNP outcome outcomes peptide predict Prognosis Prognostic value progression proinflammatory cytokines proteomic proteomics proteomics. Research respiratory risk stratification SARS-CoV-2 Severe acute respiratory syndrome severe cases severe COVID-19 shown translated [DOI] 10.3389/fimmu.2022.857573 PMC 바로가기 [Article Type] Review