In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivirResearch article Published on 2022-09-012022-10-05 Journal: Chemico-biological interactions [Category] 변종, 치료제, [키워드] Activation analyzed Anti-inflammatory drugs Antibiotics Antiviral appear AUC cannabidiol carboxylesterase 1 carrier CES1 clearance clinical study COVID-19 Dexamethasone enzyme evaluate evaluated fraction G143E hospitalized patient hydrolysis Hydroxychloroquine impairment in vitro in vitro study in vivo indicated individual inhibit inhibitor Interaction Ivermectin mechanism medication metabolism nine partial inhibition pharmacokinetic polymorphism produced RDV recent reduction Remdesivir required substrates suggested therapeutic agent treating COVID-19 Treatment unlikely variant with COVID-19 [DOI] 10.1016/j.cbi.2022.110097 [Article Type] Research article
Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus MonkeysArticle Published on 2022-09-012022-11-15 Journal: Pharmaceutical research [Category] COVID19(2023년), SARS, 진단, [키워드] aerosol alternative route animal model antibodies antibody antibody concentration approach caused Clinical studies Concentration demonstrated Diseases dose epithelial lining feasibility humanized monoclonal antibody inhalation intravenous Intravenous injection lung mice Mild Moderate COVID-19 Monkey nebulized Neutralizing neutralizing antibody pharmacokinetics PRNT reached remained respiratory tract safety profile SARS-CoV-2 SARS-COV-2 infection serum shown single dose Transport treating COVID-19 was used [DOI] 10.1007/s11095-022-03340-9 PMC 바로가기
RP-HPLC Method Development, Validation, and Drug Repurposing of Sofosbuvir Pharmaceutical Dosage Form: A Multidimensional StudyResearch article Published on 2022-09-012022-10-05 Journal: Environmental research [Category] COVID19(2023년), SARS, 신약개발, [키워드] Accuracy Agilent binding can be used carried Cell Chromatograph clinical trial complex component correlation coefficient demonstrated Detector development dosage drug Dynamics effective experiment forms high affinity hydrogen bonds Infection injected interacting residue less linear liquid methanol molecular docking Nsp12 occurred parameter parameters pharmaceutical Phenomenex phosphoric acid Photodiode Precision pump quantification ranged repurposing sofosbuvir specificity Standard deviation temperature thresholds treating COVID-19 USA validation was used [DOI] 10.1016/j.envres.2022.113282 [Article Type] Research article
Tetrandrine Treatment May Improve Clinical Outcome in Patients with COVID-19Article Published on 2022-09-012022-11-15 Journal: Medicina [Category] SARS, 치료제, [키워드] antibiotic Antibiotics association China Chinese clinical Clinical outcome collected cough COVID-19 COVID-19 pandemic COVID-19 patient defined diagnosis of COVID-19 effective Effectiveness Factor fatigue group IMPROVE indicated material Medicine Mild moderate natural antiviral patients SARS-CoV-2 significant difference tetrandrine Traditional Chinese medicine treat treating COVID-19 Treatment treatment for COVID-19 were assessed with COVID-19 [DOI] 10.3390/medicina58091194 PMC 바로가기
Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-analysisArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antiviral antiviral therapy clinical development Combination combinations conserved COVID-19 Critical Determining disparate effective eight eligible in vitro in vitro activity inactive interquartile range loss of activity measure median monoclonal monoclonal antibody Multidrug resistance Mutation neutralization omicron Omicron variant receptor-binding domains reduced reduction in Region reported review SARS-CoV-2 Spike protein spike receptor-binding domain Standardization susceptibility the median the SARS-CoV-2 therapeutic treating COVID-19 variant variants wild-type [DOI] 10.1128/spectrum.00926-22 PMC 바로가기
Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studiesCOVID-19 위험에 대한 감수성 증가에 기여하는 요인 식별: 멘델식 무작위 배정 연구의 체계적인 검토Article Published on 2022-08-102022-09-11 Journal: International Journal of Epidemiology [Category] 유전자 메커니즘, [키워드] ABO analyses Anthropometrics association assumption attributes Biomarkers Bipolar disorder cardiometabolic disease cardiometabolic diseases Chronic kidney disease contributing to coronavirus disease Coronavirus disease 2019 COVID-19 deficit disease disorder drug English evaluated Evidence Factor Factors fibrosis Genetic help higher risk Hospitalization hyperactivity identify identifying Idiopathic pulmonary fibrosis IL-6 inception Increases increases in Inflammatory factor inflammatory factors interleukin Intervention ischaemic stroke Kidney disease mendelian randomization Mendelian randomization studies Mendelian randomization study OAS1 obesity outcome predicted predisposition protein expression proteomic pulmonary fibrosis risk Schizophrenia searched selected severity smoking socio-demographic suggested susceptibility systematic review target targets treating COVID-19 Vitamin D [DOI] 10.1093/ije/dyac076 PMC 바로가기 [Article Type] Article
Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamicsArticle Published on 2022-08-102022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acting Activation alleviate Analysis analyzed Anti-inflammatory effects Apoptosis Baidu binding binding energy binding free energy bioinformatics Bioinformatics analysis carried chemotaxis clinical symptom Clinical symptoms Combination component Corona COVID-19 CSF2 database disease docking effective gene target GeneCard hydrogen bonds immune response Immunity IMPROVE Inflammation inflammatory cell Inflammatory factor Inflammatory response ingredient inhibiting Intersection KEGG Lymphocytes mechanism mechanism of action molecular molecular docking molecular dynamics monomer NLRP3 Pachypodol pandemic Patient platform Protein protein targets radius of gyration reduce Research residue SARS-COV-2 infection screened signaling pathway significantly solvent stability targets TCMSP database therapeutic treating COVID-19 Treatment was used White blood cell Xuanfei Baidu granule [DOI] 10.3389/fcimb.2022.965273 PMC 바로가기
Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease아니소다민은 시험관 내에서 SARS-CoV-2 감염을 강력하게 억제하고 주요 프로테아제를 표적으로 합니다Article Published on 2022-08-062022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acid residue analyzed Anisodamine Antiviral antiviral activity antiviral agent cells Chinese co-cultured coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cys145 disease docking score effective drug effective drugs Gly143 H-bond HEK293 immunofluorescence assay in vitro indicated Infection inhibit M pro main protease molecular docking molecular docking studies Molecular docking study pandemic predicted protease pseudovirus entry reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppressed target the SARS-CoV-2 therapeutic drug Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 Vero E6 VERO E6 cells viral infection [DOI] 10.1016/j.bbrc.2022.05.024 PMC 바로가기 [Article Type] Article
Host genetic basis of COVID-19: from methodologies to genesCOVID-19의 숙주 유전적 기반: 방법론에서 유전자까지Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age association burden Burden test caused CFTR clinical manifestation Clinical outcome Comorbidities condition Coronavirus-2 COVID-19 COVID-19 Host Genetics Initiative COVID-19 pandemic COVID-19 patient COVID-19 patients described diagnostics disease severity explain Genetic genetic marker genome-wide significant genomic genomic loci GWAS help Initially initiative International loci methodology Predictive model provided public health rare variant SARS-CoV-2 SARS-COV-2 infection SELP Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Sex susceptibility the disease Therapeutics TLR3 TLR7 TMPRSS2 treating COVID-19 vaccination [DOI] 10.1038/s41431-022-01121-x PMC 바로가기 [Article Type] Review
Clinical Effect of Early administration of Tocilizumab Following the Initiation of Corticosteroid Therapy for Patients with COVID-19Article Published on 2022-08-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome addition administration analyzed baseline blood cell count C-reactive protein caused clinical Clinical characteristics combination therapy coronavirus Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 determine drug early administration Effect effective Efficacy evaluated global pandemic groups hospital Hospitalized Initiation maximum body temperature not significantly different oxygen-free day Patient patients with COVID-19 Result SARS-CoV-2 significant decrease significantly higher significantly lower significantly more survival rate Tocilizumab tocilizumab administration treated treating COVID-19 two groups white with COVID-19 Wuhan [DOI] 10.1016/j.jiac.2022.08.021 [Article Type] Article