Effects of different corticosteroid therapy on severe COVID-19 patients: a meta-analysis of randomized controlled trials중증 COVID-19 환자에 대한 다양한 코르티코스테로이드 요법의 효과: 무작위 대조 시험의 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: Expert review of respiratory medicine [Category] SARS, 임상, [키워드] adverse event adverse events analyzed benefit clinical trials Corticosteroid corticosteroid therapy corticosteroid treatment corticosteroid treatments Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database Dexamethasone dosage dose drug Effect Efficacy Efficacy and safety eligible evaluated expert for inclusion identify IMPROVE increased mortality low dose dexamethasone management mechanical ventilation Meta-analysis Mortality mortality. no difference opinion oxygen oxygen support patient survival Placebo randomized clinical trial Randomized controlled trial RCTs reduce reduction risk of death searched Secondary infection secondary infections severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly standard care statistical analysis subgroup of patient subgroup of patients survival Treatment treatment of COVID-19 patients Trial use of corticosteroid [DOI] 10.1080/17476348.2021.1983429 PMC 바로가기 [Article Type] Meta-Analysis
Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro심황 뿌리 및 그 생물 활성 성분 Curcumin은 시험관 내에서 SARS-COV-2를 효과적으로 중화시킨다.Article Published on 2021-09-232022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] Curcuma longa acute respiratory syndrome Antiviral antiviral activity antiviral drug antiviral drugs causative agent cell culture supernatants Clinical studies clinical study complementary Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Curcumin effective Effectiveness elicit favor herbal medicine human Calu-3 cells in vitro ingredient investigated neutralized Nutritional Supplement reduced respiratory root SARS-CoV-2 SARS-CoV-2 RNA Severe acute respiratory syndrome significantly Traditional Treatment treatment of COVID-19 patients turmeric turmeric root Type Vero E6 virus [DOI] 10.3390/v13101914 PMC 바로가기 [Article Type] Article
In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.Research Article Published on 2021-09-172022-08-13 Journal: PLoS Pathogens [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] absence accumulation acting Affect animal model animal models Antiviral antiviral drug approved Author backbone changes in characterisation circulating SARS-CoV-2 variant Clinical management conserved coronavirus COVID-19 patients displaying drug-resistant EIDD2801 Evidence evidence of excess FDA FDA approval Frequency genetics immune immune pressure immune selection implication in vitro indicate low frequency morbidity and mortality mutants Mutation no evidence of not affect Nsp12 nucleoside occurred overcome passage patients polymerase Population predicted provide RDV Remdesivir replication advantage residue resistant mutants responsible risk RNA virus RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selected sensitivity Sequencing single mutation small molecule Substitution substitutions Surveillance the SARS-CoV-2 genome Transmission Treatment treatment of COVID-19 patients variants of concern Viral viral replication virus virus viruses widespread worldwide pandemic [DOI] 10.1371/journal.ppat.1009929 PMC 바로가기 [Article Type] Research Article
AVIFAVIR for Treatment of Patients With Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial중등도 코로나바이러스 질환 2019(COVID-19) 환자 치료를 위한 AVIFAVIR: 2상/3상 다기관 무작위 임상 시험의 중간 결과Clinical Trial Published on 2021-08-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] AVIFAVIR clearance clinical clinical trial COVID-19 COVID-19 patients Favipiravir favipiravir. Interim Ministry of Health Patient phase Registration Result RNA polymerase inhibitor Safe SARS-CoV-2 SARS-CoV-2 viral Treatment treatment of COVID-19 patients viral clearance [DOI] 10.1093/cid/ciaa1176 PMC 바로가기 [Article Type] Clinical Trial
The Current Status and Challenges in the Development of Vaccines and Drugs against Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2)중증 급성 호흡기 증후군-코로나 바이러스 -2 (SARS-COV-2)에 대한 백신 및 약물의 발달의 현재 상태와 도전.Review Published on 2021-06-012022-09-10 Journal: BioMed Research International [Category] 변종, 신약개발, 진단, 치료기술, [키워드] acute respiratory distress addition addressed angiotensin Angiotensin-converting enzyme Antibody Response Antibody-dependent enhancement bind cause challenge change characterized Clinical management clinical manifestation clinical manifestations clinically Complete complications of COVID-19 coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient COVID-19 patients current Cytokine storm described develop development drug effective eosinophil greater Hypothesis Immunity immunopathological include individual Infection infiltration lack lung Lungs lymphopenia management mechanism mechanisms membrane molecular molecular and serological tests mononuclear cell mutant pathogenesis of SARS-CoV-2 pathophysiology patients Pneumonia Prevent protease PROTECT provide reduce Replication Research respiratory respiratory distress S glycoprotein SARS-CoV-2 serological test Serological tests Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Spread status T cell tested the antibody response therapeutic therapeutic intervention Treatment treatment of COVID-19 patients understanding Vaccine variant variants of SARS-CoV-2 variations Viral Viral load virulence virus virus transmission [DOI] 10.1155/2021/8160860 PMC 바로가기 [Article Type] Review
Efficient management strategy of COVID-19 patients based on cluster analysis and clinical decision tree classification클러스터 분석 및 임상 의사 결정 트리 분류를 기반으로 한 코로나19 환자의 효율적인 관리 전략Article Published on 2021-05-052022-09-10 Journal: Scientific Reports [Category] 치료법, 치료제, [키워드] Algorithm Analysis characteristic Chest CT image Chest CT images Clinical characteristics clinical decision Clinical diagnosis Clinical prognosis Cluster Cluster analyses cluster analysis COVID-19 patient COVID-19 patients Critical Decision tree deteriorate during treatment Efficacy efficient evaluated feature flow chart ground glass Health care health resources help Hospitalization IMPROVE individual Kaplan–Meier Kaplan–Meier survival curve analysis Logistic management Patient patients performed Predictive Predictive value Prognosis public health recognize resource Retrospective study risk Risk assessment risk factor Risk factors Signs and symptoms survival survival curve symptoms of COVID-19 the patient therapeutic efficacy treated Treatment treatment of COVID-19 patients two groups utilization Wuhan [DOI] 10.1038/s41598-021-89187-3 PMC 바로가기 [Article Type] Article
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model경구 전달된 MK-4482는 시리아 햄스터 모델에서 SARS-CoV-2 복제를 억제합니다Article Published on 2021-04-162022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] Administered animals Antiviral Antiviral agents approved benefit COVID-19 pandemic COVID-19 patients drug effective Evidence Human Infection inhibit inhibitory effect nucleoside Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Support These data Treatment treatment of COVID-19 patients utility Vaccine while [DOI] 10.1038/s41467-021-22580-8 PMC 바로가기 [Article Type] Article
Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults우리 국가를 위한 수동 면역 시험(PassITON): 입원한 성인에서 COVID-19 회복기 혈장을 평가하는 무작위 위약 대조 임상 시험을 위한 연구 프로토콜Study Protocol Published on 2021-03-202022-09-10 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] 1:1 7-category ordinal scale activity Administered adults hospitalized blinded chimeric Clinical efficacy clinical status clinical trial clinical trials conducted convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19 patient daily living demonstrated detect Efficacy eligible Evidence Hospitalized include indicated less moderate moderate to severe Mortality multicenter nation Neutralizing antibodies neutralizing function normal activities Odds ratio Ordinal Scale oxygen oxygen-free days pandemic Pandemics Pass Passive passive immunity Patient placebo-controlled plasma Primary outcome Randomized randomized clinical trial Randomized controlled trial respiratory Respiratory Support respiratory symptom respiratory symptoms robust SARS-CoV-2 SARS-CoV-2: convalescent plasma secondary outcome severe COVID-19 Study protocol supplementary material symptomatic disease These data Treatment treatment of COVID-19 patients Trial Trial registration USA Viral Virus neutralization with COVID-19 [DOI] 10.1186/s13063-021-05171-2 PMC 바로가기 [Article Type] Study Protocol
The plausible mechanisms of tramadol for treatment of COVID-19COVID-19 치료를 위한 트라마돌의 그럴듯한 메커니즘Review Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 신약개발, 치료법, [키워드] ACHE activate Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant therapy age Anti-inflammatory anti-inflammatory effect antioxidant antitussive approved C-reactive protein caused clinical outcomes clinical trials Complication coronavirus coronavirus disease coronavirus disease-2019 correlated cough COVID-19 COVID-19 patient COVID-19 patients CRP cytokine Cytokine storm dependence disease dismutase drug Effect effective elevated ENhance enzyme Evidence FIBRIN glutathione Glutathione peroxidase headache help hypocoagulable Hypocoagulable effect IL-2 Immune-enhancing increase Increases interleukin lack Lactate lactate dehydrogenase LDH lead less malondialdehyde management mechanism mechanism of action medication moderate moderate to severe Mortality Multiple natural killer Necrosis old age oxidative damage Pain pathogen Pathogens patients patients with COVID-19 peroxidase Pneumonia polymerization PROTECT Pseudomonas aeruginosa psychiatric disorder Psychiatric disorders recent respiratory respiratory depression Respiratory failure SARS-CoV-2 SARS-COV-2 infection secretion severe COVID-19 patient severe COVID-19 patients severe pain severity Superoxide Superoxide Dismutase Support suppress T-cell T-cells therapeutic option therapy for COVID-19 thrombosis TNF-α tramadol Tramadol. Treatment treatment of COVID-19 patients tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Venous Thromboembolism [DOI] 10.1016/j.mehy.2020.110468 PMC 바로가기 [Article Type] Review
Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic ReviewCOVID-19에 대한 면역 요법, 항바이러스 요법 또는 둘 다: 체계적인 검토Article Published on 2020-12-012022-09-11 Journal: Drugs [Category] MERS, SARS, 진단, 치료제, [키워드] Admission Anakinra analysed Antiviral antivirals article articles Baricitinib case reports Characteristics Chloroquine Clinical features clinical impact Colchicine combination therapy control group COVID-19 COVID-19 patient cumulative Cytokine release syndrome database deaths Dexamethasone discharge disease dysregulation Efficacy eligibility criteria English language Evidence exclusion explain Favipiravir first stage Google Scholar helping High-flow oxygen Hydroxychloroquine identify immune immune dysregulation immune response Inclusion Inconclusive indicated Infection intensive care intensive care unit intensive care unit admission item itolizumab large trial Loading dose Lopinavir Lopinavir/ritonavir management medRxiv meta-analyses Mortality Open-label oxygen Pathogenesis pathogenesis of COVID-19 pathogenic mechanism patients primary end point PRISMA Randomised controlled trials rationale RCTs reduced reduction Remdesivir removal reported Reporting requiring high-flow oxygen retrospective review Ritonavir ruxolitinib sarilumab SARS-CoV-2 SARS-COV-2 infection significantly siltuximab supportive therapy systematic review systematic reviews the disease the SARS-CoV-2 therapeutic therapeutic agent Therapeutic approach therapeutic approaches therapy Time to recovery Tocilizumab Treatment treatment of COVID-19 patients Trial trials triggered USA was performed were excluded [DOI] 10.1007/s40265-020-01421-w PMC 바로가기 [Article Type] Article