Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2Article Published on 2022-08-242022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] 3CLpro Accuracy antiviral drugs approach assessment binding free energy capsid demonstrated dependent on drug Drug discovery drug resistance effective Effectiveness emtricitabine experiment HBV HIV identify mechanism MM-GBSA Mutation mutations Nirmatrelvir performed predict predicted primary mechanism Protein Research residue residue scanning. resistance Rt SARS-CoV-2 selected sensitivity time-consuming treatment strategy Viral protein [DOI] 10.3390/molecules27175413 PMC 바로가기
Modelling the microelimination of chronic hepatitis C in the canton of Bern, Switzerland: Reaching the Swiss Hepatitis Strategy goals despite the impact of the COVID 19 pandemic스위스 베른 주의 만성 C형 간염 미세 제거 모델링: COVID 19 전염병의 영향에도 불구하고 스위스 간염 전략 목표 달성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] A형 간염, Fulltext, 치료제, [키워드] Bern Care cirrhosis COVID 19 COVID-19 crisis death diagnosed disease Elimination Epidemiology HCV Hepatitis hepatitis C hepatitis C virus Hepatocellular carcinoma identify incidence increase in Infection Markov Mortality pandemic Patient Prevalence reduction scenario Standard of care Strategy Switzerland target targets the WHO treated Treatment Treatment strategies treatment strategy [DOI] 10.1371/journal.pone.0272518 PMC 바로가기 [Article Type] Article
Glucocorticoid-Induced Hyperglycemia Including Dexamethasone-Associated Hyperglycemia in COVID-19 Infection: A Systematic ReviewReview article Published on 2022-08-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] 임상, 진단, [키워드] added article clinical guideline Cochrane Library conducted Controlled trial COVID-19 COVID-19 pandemic database Dexamethasone diabetes effective End points evaluated glucocorticoid hyperglycemia Including insulin management objective Patient patients with COVID-19 RCT RCTs regimens Respiratory Support Result review Standard of care steroid Support synonym systematic review treatment strategy variety Web of Science widespread [DOI] 10.1016/j.eprac.2022.07.014 [Article Type] Review article
MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
The significance of advanced COVID-19 diagnostic testing in pandemic control measures전염병 통제 조치에서 고급 COVID-19 진단 테스트의 중요성Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advancement antibody Antigen causative agent caused combating Community condition conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak Defense diagnostic diagnostic test diagnostic testing diagnostic tests disease effort evade Evolution Hospitalization measure methodology mortality rates Mutation Novel coronavirus novel coronavirus disease nuclei pandemic Pandemic conditions reduced SARS-CoV-2 Scientific community Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown Transmissibility Treatment strategies treatment strategy Vaccine Viral transmission Viral variants virus [DOI] 10.7150/ijbs.72837 PMC 바로가기 [Article Type] Review
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance약물 내성을 예측하고 피하기 위한 SARS-CoV-2 주요 프로테아제의 기질 외피 정의Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral therapies antiviral therapy antivirals binding cleavage Clinical use COVID-19 pandemic Critical drug resistance effective Efficacy elements enzyme Enzymes High-resolution identify inhibitor inhibitors M pro maturation morbidity and mortality Mutation nine peptide peptides polymerases predict promote protease Protease inhibitor protease inhibitors Proteases resistance mutations robust SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variant SARS-CoV-2 variants severe disease Spread Structure susceptible to define treatment strategy Vaccine viral pathogen [DOI] 10.1038/s41467-022-31210-w PMC 바로가기 [Article Type] Article
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies Research Published on 2022-06-062022-10-05 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] activated acute respiratory syndrome approach blocked cathepsin Cell cleavage site conformations conserved coronavirus CTSL CTSL cleavage demonstrated domain Effect Ex vivo exhibited experiment host protease human donor Infection inhibitor Live virus lung tissue mechanism membrane fusion mice mutated novel omicron Prevent promoted Protein pseudovirus RBD reduced S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants strain the S protein therapy Treatment treatment strategy Vaccine variant viral infection virus [DOI] 10.1038/s41421-022-00419-w [Article Type] Research
Deleterious effects of nervous system in the offspring following maternal SARS-CoV-2 infection during the COVID-19 pandemic Reviews Published on 2022-06-062022-10-05 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] acute respiratory syndrome addition Affect Brain children coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic Effect fetal group IMPROVE infected with SARS-CoV-2 mechanism mitigate nervous system neuropsychiatric disease offspring pandemic populations Pregnancy pregnant women Prognosis Prophylactic psychiatric disorder psychological support SARS-CoV-2 SARS-COV-2 infection shown susceptible treatment strategy vaccination women [DOI] 10.1038/s41398-022-01985-z [Article Type] Reviews
Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN)Observational Study Published on 2022-06-012022-10-04 Journal: CJEM [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95% confidence interval Admission advance Care Characteristics collected data Coronavirus 2019 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient criteria Critical care Department discharge discharged disease severity Efficiency eligible Emergency English enrolled French health system hospital hospitalisation Hospitalization ICU admissions in-hospital mortality invasive Invasive mechanical ventilation less mechanical ventilation Mortality network nous Odds ratio outcome outcomes pandemic pandemic waves. Patient patient outcomes patients presenting Primary outcome Rapid reductions in regression modeling remained resource Resource utilization response retrospective SARS-CoV-2 second wave secondary severe COVID-19 therapy treatment strategy Ventilation [DOI] 10.1007/s43678-022-00275-3 PMC 바로가기 [Article Type] Observational Study
Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child일본 어린이의 불응성 COVID-19 관련 다기관 염증 증후군에 대한 Infliximab 치료Article Published on 2022-06-012022-09-12 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Administered Asia Aspirin children circulating ferritin clinical feature clinical phenotype Clinical symptoms Cohort coronavirus disease COVID-19 develop diagnosed East extreme genetic background heterogeneous Hyperferritinemia hyperinflammation Immunopathogenesis immunopathology IMPROVE incidence induce Inflammation Inflammatory infliximab initial Intervention Intravenous immunoglobulin Japan Japanese Kawasaki disease lymphopenia MIS-C multisystem inflammatory syndrome in children onset of fever outcome Pathogenesis Patient Prednisolone Region reported required Symptom syndrome Therapies therapy treated Treatment treatment strategy tumor necrosis factor-α [DOI] 10.1016/j.jiac.2022.01.011 PMC 바로가기 [Article Type] Article