tropism – Page 2 – Communicable Diseases Research

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

N501Y 스파이크 대체는 SARS-CoV-2 감염 및 전파를 향상시킵니다

Article

Published on 2022-02-012022-09-11
Journal: Nature
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] adaptive affinity airway Alpha Alpha variant approach B.1.1.7 B.1.1.7 variant Brazil cellular receptor cellular receptors convergent evolution COVID-19 pandemic Deletion deletions Efficiency eight ENhance epithelial cells Evolution genetics increase in Infection interact Mutation N501Y nonsynonymous mutation phenotype Prevalence primary human airway Primary human airway epithelial cells Replication SARS-CoV-2 SARS-COV-2 infection South Africa spike mutation Spike protein Substitution substitutions suggested summer The B.1.1.7 the spike protein Transmission tropism upper airway variant viral genome viral spike protein Viral transmission
[DOI] 10.1038/s41586-021-04245-0 PMC 바로가기 [Article Type] Article

A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air

Article

Published on 2022-01-012023-06-14
Journal: The Journal of Infectious Diseases
[Category] Fulltext, 신종인플루엔자,

[키워드] ferrets Influenza virus Transmission tropism
[DOI] 10.1093/infdis/jiab286 PMC 바로가기

Special Issue: Virus Receptors and Viral Tropism

Editorial

Published on 2021-12-312022-10-28
Journal: Viruses
[Category] Coronavirus, SARS,

[키워드] tropism
[DOI] 10.3390/v14010068 PMC 바로가기 [Article Type] Editorial

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

신장 오르가노이드 및 임상 인구에서 SARS-CoV-2 반응의 교차 검증

Research Article

Published on 2021-12-222022-09-10
Journal: JCI Insight
[Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] Alpha ameliorated Apoptosis Beta blocked Cell cell types Clinical data comparable COVID-19 Critical Critically ill Critically ill patient critically ill patients Cross-validation feature gene expression pattern gene expression patterns Genetic diseases infect Infection interferon interferon pathway iPS cells Kidney disease kidney infection kidney organoid kidneys mechanism Molecular pathology morphology Nephrology organ Organoid organoids peptides polycystic kidney polycystic kidney disease Population populations proteomic proximal proximal tubules reflect reflected replicating virus response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral susceptibility target organs Therapeutics Therapies Treatment tropism upregulation Urine variant Viral viral fitness
[DOI] 10.1172/jci.insight.154882 PMC 바로가기 [Article Type] Research Article

Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation

SARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.

407

Published on 2021-11-032022-08-13
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,

[키워드] O- abrogate Alpha alpha and delta variants Amino acid amino acids cells circumvent cleavage coronavirus decrease delta variant Delta variants dependent on expressed family members furin furin cleavage furin cleavage of S furin cleavage site GALNT GALNT enzyme global pandemic glycosylating S glycosylation highlight host O -glycosylation host-mediated O -glycosylation human respiratory cell human respiratory cells increase insertion insertion site modulated modulating Mutation O -glycosylation P681 P681 mutation P681 mutations position position 681 proline pseudoviral infectivity respiratory responsible resulting SARS-CoV-2 coronavirus SARS-COV-2 infection shown Significance spike Spike protein syncytia formation target targets the SARS-CoV-2 the spike protein tropism unique Viral viral infectivity viral infectivity/tropism
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407

Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses

Article

Published on 2021-10-012023-05-31
Journal: Emerging Infectious Diseases
[Category] Fulltext, 신종인플루엔자, 조류인플루엔자,

[키워드] alveolar epithelial cells China Clade 2.3.4.4 Hong Kong HPAI H5Nx human airway organoids Influenza innate host responses Risk assessment tropism viruses
[DOI] 10.3201/eid2710.210297 PMC 바로가기

Molecular Biology and Pathological Process of an Infectious Bronchitis Virus with Enteric Tropism in Commercial Broilers

Article

Published on 2021-07-282022-10-28
Journal: Viruses
[Category] Coronavirus,

Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients

COVID-19 환자의 부검에서 SARS-CoV-2의 다중 전신 세포 친화성

Article

Published on 2021-07-272022-09-11
Journal: Cells
[Category] SARS, 치료기술,

[키워드] ACE2 adrenal gland alteration analyzed assigned Autopsies Autopsy bowel Cell Chain Reaction correlation COVID-19 COVID-19 autopsy sample electron microscopy endothelial cells epithelial epithelial cell epithelial cells expressing fatal COVID-19 FFPE formalin formalin-fixed paraffin-embedded formalin-fixed paraffin-embedded (FFPE) tissue heart histology histopathological immunohistochemistry In situ hybridization Infection kidney liver lung lymph nodes major organs Microscopy organ systems organs oropharynx paraffin polymerase chain polymerase chain reaction Post-mortem Prostate Replication respiratory respiratory tract RNA salivary glands SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 RNA shown Skeletal muscle skin the SARS-CoV-2 Thyroid TMPRSS2 tonsils Trachea transmission electron microscopy tropism tropism of SARS-CoV-2 Viral Viral detection Viral protein Viral RNA virus particle virus particles
[DOI] 10.3390/cells10081900 PMC 바로가기 [Article Type] Article

Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models

Research Article

Published on 2021-06-232022-10-30
Journal: mSphere
[Category] COVID-19, MERS, SARS,

[키워드] accumulating ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 associated immune response Brain cell tropism cell type cells Central nervous system cerebrospinal fluid CNS contribute coronavirus COVID-19 COVID-19 patients Culture cultures disease Evidence expression H5N1 H5N1 influenza A H5N1 virus highly pathogenic hiPSC neurons Human Hypothesis IL-8 induced infect Infection influenza A virus Influenza virus interferon Invasion investigated Kinetics local immune response Model Neural Neurological complication Neurological complications Neuron neurons neurotropic neurotropism NPR1 olfactory Pathogenesis pluripotent stem cell protease replicated replication kinetics response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serine 2 Spread STEM subsequent Support TMPRSS2 transmembrane triggered triggering tropism type III interferon variety virus virus replication virus spread
[DOI] 10.1128/mSphere.00270-21 PMC 바로가기 [Article Type] Research Article

In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic Coronaviruses

Review Article

Published on 2021-06-212022-10-27
Journal: BioMed Research International
[Category] COVID-19,