Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors바이러스 RNA 합성 분석 및 항바이러스 억제제 스크리닝을 위한 안정적이고 편리한 SARS-CoV-2 복제 시스템 엔지니어링Research Article Published on 2021-01-192022-09-10 Journal: mBio [Category] 변종, 신약개발, 치료제, [키워드] Analysis antivirus drug antivirus drugs caused clinically contagious COVID-19 drug Engineering etiologic agent expressing feature functional global pandemic indicated inhibit inhibitor inhibitors kinase inhibitors Laboratory Mutation ORF6 ORF8 Plasmid plasmids platform provide provided replicon reported required Research response RNA safety replicon SARS-CoV-2 SARS-CoV-2 viruses Screening synthesis System tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors variations Viral Viral mutations viral replication Viral RNA viral RNA synthesis viruses wild-type [DOI] 10.1128/mBio.02754-20 PMC 바로가기 [Article Type] Research Article
Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesisCOVID-19의 표현형을 결정하는 숙주-바이러스-약물 상호작용: 데이터 기반 가설Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] Coronavirus, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 affecting cardiovascular disease clinical phenotypes Comorbidities Comorbidity Compound compounds Corticosteroid Corticosteroids COVID-19 COVID-19 susceptibility data-driven determinant diabete diabetes drug interaction enrichment analysis Evidence gene set enrichment analysis gene signature gene signatures Host Hypothesis Infection inhibitors Interaction kinase inhibitors micronutrients NSAIDS overlapping phenotype Phenotypes SARS-CoV-2 severe COVID-19 statins synergism transcriptional Treatment tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors Viral virus [DOI] 10.1016/j.mehy.2020.110275 PMC 바로가기 [Article Type] Article
Outcome of COVID-19 in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitorsArticle Published on 2020-10-012023-07-11 Journal: Journal of Oncology Pharmacy Practice [Category] SARS, [키워드] chronic myeloid leukemia. COVID-19 SARS-CoV-2 tyrosine kinase inhibitors [DOI] 10.1177/1078155220953198 PMC 바로가기
High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2Article Published on 2020-07-132022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] 3CL pro acute respiratory syndrome amino acid residues approved drugs bind binding catalytic dyad characterized Compound compounds computer-aided drug design coronavirus COVID-19 demonstrated docking Drug repurposing drugs enzyme functional group Hormones Hydrogen bond identify in silico drug design in vitro include inhibitor inhibitors inhibitors of SARS-CoV-2 inhibitory activity Ligand monocyclic natural products protease protocol Replication reported residue SARS-CoV virus SARS-CoV-2 Screening severity of COVID-19 starting point the SARS-CoV-2 throughput tyrosine kinase inhibitors viral replication inhibition [DOI] 10.3390/molecules25143193 PMC 바로가기 [Article Type] Article
Ibrutinib‐induced severe liver injuryCase Report Published on 2017-03-152023-08-30 Journal: Clinical Case Reports [Category] E형 간염, [키워드] chronic lymphocytic leukemia Ibrutinib Liver injury Richter's syndrome tyrosine kinase inhibitors [DOI] 10.1002/ccr3.881 PMC 바로가기 [Article Type] Case Report