Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기
Emotions and Topics Expressed on Twitter During the COVID-19 Pandemic in the United Kingdom: Comparative Geolocation and Text Mining AnalysisArticle Published on 2022-10-052022-11-16 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach can be used change changed Comparative conditions COVID-19 COVID-19 pandemic declined deep learning deep learning-based method dominant emotion emotion detection epidemiological epidemiological situation Express expressing expression geolocation Government Health increase in measure natural language processing negative emotion Neutral omicron optimism outbreak over pandemic platform positive positive attitude Positive emotion proportion public health sentiment analysis social media text text mining the epidemic thought Topic topic modeling. Twitter United Kingdom vaccination variant [DOI] 10.2196/40323 PMC 바로가기
Epidemiology of Early Monkeypox Virus Transmission in Sexual Networks of Gay and Bisexual Men, England, 2022Article Published on 2022-10-012023-06-10 Journal: Emerging Infectious Diseases [Category] Fulltext, 원숭이두창, [키워드] England Epidemiology Gay and bisexual men men who have sex with men Monkeypox MSM Transmission United Kingdom viruses. [DOI] 10.3201/eid2810.220960 PMC 바로가기
Genomic diversity of SARS-CoV-2 in Pakistan during the fourth wave of pandemic전염병의 네 번째 물결 동안 파키스탄에서 SARS-CoV-2의 게놈 다양성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha B.1.617.2 Beta variant characteristic circulating circulation conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D950N delta variant Delta variants exhibited followed by G142D genomic Genomic surveillance Germany globe highlight Illumina isolate isolates Karachi L452R lineages P681R Pakistan pandemic Patient Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus Singapore spike mutation T19R T478K United Kingdom V483A variant variants variants of concern variants of concern. whole-genome sequencing [DOI] 10.1002/jmv.27957 PMC 바로가기 [Article Type] Article
Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
Fear of COVID-19 reinforces climate change beliefs. Evidence from 28 European countriesResearch article Published on 2022-10-012022-10-05 Journal: Environmental Science & Policy [Category] 진단, [키워드] Climate change beliefs country COVID-19 Effect European European country European Union Europeans fear Impact measure member Multilevel regression robust state survey union United Kingdom [DOI] 10.1016/j.envsci.2022.07.029 [Article Type] Research article
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?Review Published on 2022-10-012022-10-06 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE-2 analyzed Angiotensin converting enzyme-2 B.1.1.529 catastrophic circulating contagious COVID-19 COVID-19 cases COVID-19 pandemic detrimental dissemination dominant Efficacy effort Evolution explained feasible feature FIVE Genetic hazard host receptor immune evasion immunization implication include Lineage Measures mechanism Mutation omicron Omicron variant other variant pandemic pharmacological physical Population prevalent strain raise RBD reported S-protein SARS-CoV-2 South Africa spike mutation Spread Sublineages surpassed Surveillance susceptible the receptor-binding domain the spike protein United Kingdom Vaccine vaccine effectiveness variant variants of concern variants of SARS-CoV-2 variants. viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113522 PMC 바로가기 [Article Type] Review
Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UKArticle Published on 2022-09-292022-11-15 Journal: Clinical and experimental immunology [Category] SARS, 진단, [키워드] access age anti-SARS-CoV-2 baseline co-morbidity Cohort Combination convalescent plasma COVID-19 COVID-19 treatment CVID demonstrated Dexamethasone died Fatality rate General population high risk hospital Hypogammaglobulinemia IFR immunodeficiency inborn errors of immunity increased the risk Increasing individual Infection Lymphocyte count lymphopenia monotherapy Mortality network outcome overall mortality Patient PID Primary immunodeficiencies receiving REGN-CoV2 Remdesivir reported risk factor SARS-CoV-2 SARS-COV-2 infection secondary immunodeficiencies. therapeutic Tocilizumab Treatment United Kingdom [DOI] 10.1093/cei/uxac008 PMC 바로가기
Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experienceArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] Antiviral B.1.1.529 changed cohorts cohorts of patient COVID-19 COVID-19 in patient CVID dominant early stage elevated Fatality rate General population Hospitalization immunodeficiency immunodeficient patient Impact improvement inborn errors of immunity individual Intervention monoclonal antibody morbidity and mortality Mortality MOST naïve nasopharynx omicron outcome pandemic Patient patients PCR PID Primary Immunodeficiency reduced risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary immunodeficiency serological response severe COVID-19 shown significantly significantly increased the SARS-CoV-2 Treatment treatment strategy United Kingdom vaccination vaccination. vaccine dose variant Viral detection viral variant widespread [DOI] 10.3389/fimmu.2022.984376 PMC 바로가기
Wellbeing and coping of UK nurses, midwives and allied health professionals during COVID-19-a cross-sectional studyArticle Published on 2022-09-212022-11-16 Journal: PLoS ONE [Category] SARS, 변종, [키워드] backbone benefit Burnout Care conducted COPE coping coping strategies Coping strategy COVID-19 pandemic cross-sectional cross-sectional survey Descriptive statistics Deterioration Effect examined family Final Health healthcare Healthcare professional healthcare services inventory life mental health Multiple linear regression Nurse Nurses patients with COVID-19 phase Phase 1 Phase 2 Prevent professional Psychological Quality repeated respond scale significant effect significantly lower Strategy Stressor timepoints United Kingdom variable variant work [DOI] 10.1371/journal.pone.0274036 PMC 바로가기