Production and characterization of chimeric SARS-CoV-2 antigens based on the capsid protein of cowpea chlorotic mottle virus동백색 반점 바이러스의 캡시드 단백질을 기반으로 하는 키메라 SARS-CoV-2 항원의 생산 및 특성화Article Published on 2022-07-312022-09-11 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] absence Antigen antigens BALB/c mice characterized chimeric Chimeric protein clinical evaluation COVID-19 pandemic Cowpea cultures develop E. coli Efficacy epitope Epitopes expressed expression full-length S protein Humoral response IgG antibody IgG antibody titer immunogenic Inclusion induce interfere mutant offer Pathogens plant plant virus Plant virus. Production Protein purified recognize resulting SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike protein spike Spike protein subunit Subunit vaccine subunit vaccines Support the SARS-CoV-2 the vaccine Vaccine vaccine candidate vaccine candidates vaccine platform virus virus VLP VLPs [DOI] 10.1016/j.ijbiomac.2022.06.021 PMC 바로가기 [Article Type] Article
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Subunit vaccine. Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of concern. variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article
Artificial Intelligence-Based Data-Driven Strategy to Accelerate Research, Development, and Clinical Trials of COVID VaccineCOVID 백신의 연구, 개발 및 임상 시험을 가속화하기 위한 인공 지능 기반 데이터 기반 전략Review Published on 2022-07-062022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens Antiviral artificial artificial intelligence caused clinical Clinical practice clinical trial clinical trials computational approach Computational approaches coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 datasets detect development diagnostic drug effective healthcare facility Human coronavirus identify inhibitory introduced Lower medical system Model optimization pandemic problem Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Strategy therapy unique vaccination Vaccinations Vaccine vaccine candidates Vaccine development virus [DOI] 10.1155/2022/7205241 PMC 바로가기 [Article Type] Review
Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine Research Published on 2022-07-042022-10-05 Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome airway antibodies approved CD4+ CD8+ T cell coronavirus COVID-19 vaccine cytokine expression profile domain dose elicit elicited ENhance Exosome hamsters Immunity Infection Inflammatory Intramuscular injection live SARS-CoV-2 lung parenchyma Lungs mice mRNA vaccine mucosal IgA response Preclinical Testing RBD RBD-specific IgG reduced SARS-CoV-2 SARS-CoV-2 pseudovirus severe pneumonia temperature the RBD the vaccine Vaccine vaccine candidates Virus-like particle [DOI] 10.1038/s41551-022-00902-5 [Article Type] Research
Covid-19 vaccines and variants of concern: A reviewCovid-19 백신 및 우려 변종: 검토Review Published on 2022-07-012022-09-11 Journal: Reviews in Medical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad5-nCoV administration adverse event AZD1222 BBIBP-CorV BNT162b2 caused Cell-mediated immunity Clinical studies CoronaVac coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease COVID-19 vaccination COVID-19 vaccines CVnCoV deaths effective vaccine Efficacy Infection mRNA mRNA vaccines mRNA-1273 Mutation nCoV Neutralising Antibodies neutralising antibody nine NVX-CoV2373 outbreak rare adverse events reported Research respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein Spread symptomatic COVID-19 symptomatic COVID-19 disease the SARS-CoV-2 vaccination Vaccine vaccine candidate vaccine candidates vaccine efficacy variant variants variants of concern variants of concern. Viral Viral vector viral vector and mRNA vaccines VOCs Wuhan-Hu-1 ZF2001 [DOI] 10.1002/rmv.2313 PMC 바로가기 [Article Type] Review
Transient production of receptor-binding domain of SARS-CoV-2 in Nicotiana benthamiana plants induces specific antibodies in immunized miceNicotiana benthamiana 식물에서 SARS-CoV-2의 수용체 결합 도메인의 일시적인 생산은 면역된 마우스에서 특정 항체를 유도합니다Article Published on 2022-07-012022-09-12 Journal: Molecular biology reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected antibodies antigen expression benthamiana caused Cell coronavirus COVID-19 pandemic diagnostic system domain drug evaluate Host identity immune immunization immunized mice immunogenicity induce Interaction mice N. benthamiana Nicotiana benthamiana PBS plant platform produced Protein RBD RBD protein RBDr receptor ACE2 SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2. Scientific community specific antibody Spike protein spread of COVID-19 Support the receptor-binding domain the SARS-CoV-2 Transient treated vaccine candidates Vaccines viral surface [DOI] 10.1007/s11033-022-07402-4 PMC 바로가기 [Article Type] Article
Emerging role of artificial intelligence in therapeutics for COVID-19: a systematic reviewReview Published on 2022-07-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, [키워드] 3CLpro Algorithm antibody applied approach approved article artificial artificial intelligence clinical evaluation clinical trial coronavirus disease COVID-19 COVID-19 therapeutics database deep learning disease drug Drug discovery Drug repurposing effective English Evidence faster Host inhibiting interactions life-threatening methodology novel drug discovery pandemic researcher SARS-CoV-2 SARS-CoV2 searched systematic review targets Vaccine vaccine candidates Vaccine development Vaccine development. Validity [DOI] 10.1080/07391102.2020.1855250 PMC 바로가기 [Article Type] Review
Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2 Research Published on 2022-06-282022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome Administered Beta clinical development controls coronavirus current domain dose Express expressing hamster hamsters Human IgA response Immunity immunization immunized immunogenic intranasal lack Lineage Lower respiratory tract Lung inflammation neutralized pre-existing immunity prefusion conformation proline substitution PROTECT Protective Protein replicated Replication respiratory tract response S-2P SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 spike protein serum IgG Serum neutralizing antibody stability stimulate the S protein the SARS-CoV-2 undetectable upper respiratory tract Vaccine vaccine candidates variants of concern WA1/2020 weight loss [DOI] 10.1038/s41541-022-00493-x [Article Type] Research