Epitope mapping of neutralising anti-SARS-CoV-2 monoclonal antibodies: Implications for immunotherapy and vaccine designArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome affected anti-SARS-CoV-2 coronavirus coronavirus disease COVID-19 COVID-19 infection death disease drug Emergency use epitope epitope mapping Epitope-based vaccine food Immunotherapy individuals Medicine monoclonal monoclonal antibody neutralising neutralising MAb neutralising monoclonal antibody. pandemic RBD reactivity reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus the SARS-CoV-2 virus Vaccine design virus [DOI] 10.1002/rmv.2347 PMC 바로가기
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerabilityArticle Published on 2022-09-012022-11-15 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome analysis antibodies antibody beta-coronavirus beta-coronavirus beta-coronaviruses Broadly neutralizing antibody conformations conserved coronavirus COVID-19 crystal structure elicit hydrophobic residue immunized indicated inhibiting Middle East mRNA murine neutralization neutralize neutralized Neutralizing recognizing S2 subunit S2-directed antibody Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 variants spike syndrome the antibody the SARS-CoV-2 Vaccine design Vaccine design. [DOI] 10.1016/j.str.2022.06.004 PMC 바로가기
Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design변이체에서 SARS-CoV-2 돌연변이 표적화에서 에피토프 보존성 고려: 백신 설계에 대한 새로운 면역정보학 접근Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity antibody antigenicity approach Avian flu calculated collected conserved Coronavirus-2 database Developing Efficacy epitope Epitopes event flu ideal identify IEDB immune Immune Epitope Database Immunity immunodominant immunogenicity immunoinformatics mutated Mutation mutations neutralization pathogenicity platform predicted preference provide reduce Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy similarity solution technique Vaccine design Vaccines variant variants virulence virus viruses [DOI] 10.1038/s41598-022-18152-5 PMC 바로가기 [Article Type] Article
Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapiesB 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination vaccination. Vaccine design virus infection [DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발Article Published on 2022-08-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 변종, [키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccine design. Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization [DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article
Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2Article Published on 2022-08-012022-11-16 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 변종, [키워드] addition adverse effect Alpha applied approach Asia B-cell chimeric Chimeric vaccine conserved contagious COVID-19 COVID-19 infection COVID-19 outbreak CTL epitope Delta delta variant docking Efficacy effort elicit Epitopes expression faster globe highly antigenic HLA HTL humoral immune response Immune simulation impacted in silico India induce infective Multi-epitope vaccine Mutation non-allergenic other variant Protein reported reverse vaccinology SARS-CoV-2 South spike spike protein. the SARS-CoV-2 the spike protein TLR4 transmission rate USA Vaccine vaccine construct Vaccine design Vaccines variant variants of concern variants of SARS-CoV-2 was performed Wuhan, China [DOI] 10.1007/s11356-022-19979-1 PMC 바로가기
Structural basis of Omicron immune evasion: A comparative computational study오미크론 면역 회피의 구조적 기반: 비교 전산 연구Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Affect analysis angiotensin antibody binding affinities binding affinity Compromised Compromised neutralisation Critical Delta develop effective Effectiveness Efficacy evaluated explain immune Immune escape immune evasion immunogenic interact Interaction interface mapped molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation neutralisation Neutralising Antibodies neutralising antibody new strain omicron Omicron variant Protein RBD Receptor binding domain receptors reported robust S protein SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 variants. several variants Spike protein the antibody the binding affinity the spike protein Vaccine Vaccine design variant variants variants of concern virus [DOI] 10.1016/j.compbiomed.2022.105758 PMC 바로가기 [Article Type] Article
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines1가 및 2가 비활성화 백신으로 면역된 햄스터에서 SARS-CoV-2 감염에 대한 교차 변이 보호Article Published on 2022-07-132022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] addition Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 circulation COVID-19 Delta delta variant determine emergence exhibited experiment form hamster hamsters highest immune evasion immune protection immunized Inactivated vaccine Inactivated Vaccines less monovalent Neutralizing antibodies omicron Omicron variant Omicron variants pandemic of COVID-19 predominant provided Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern. SARS-CoV-2 Wuhan strain Support tested Vaccine Vaccine design variant variants VoC VOCs were used [DOI] 10.7150/ijbs.72109 PMC 바로가기 [Article Type] Article
Variations of SARS-CoV-2 in the Iranian population and candidate putative drug-like compounds to inhibit the mutated proteinsResearch article Published on 2022-07-112022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] addition Affect antibody appear Ardabil benefit Candidate putative drug-like compounds Ciclesonide complex Compound conserved COVID-19 diagnosing DNA docked element Evolution Frame Genetic Genetic variant help indels indicated inducer Infection inhibit inhibitor Interaction Iran mechanism of action Meta-analysis mutated Mutation Nonstructural proteins (NSPs) Novel coronavirus NSP8 nucleotide nucleotide mutation Open reading frame (ORF) ORF1ab Orf9b Oxford polyproteins Potential Protein reported responsible resveratrol SARS-CoV-2 SARS-CoV-2 gene sequence sequenced Spread Substitution the SARS-CoV-2 Topic treating COVID-19 Vaccine design Viral proteins viral replication virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e09910 [Article Type] Research article