ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccinationChAdOx1-S 아데노바이러스 벡터백신을 비강내 투여하여 근육주사에 비해 점막면역력이 우수함Article Published on 2022-06-012022-09-12 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adenoviral vector adenoviral vector vaccine Administered Antibody titer applied approved BALB/c mice breakthrough infections CD8 T cell Cellular immune response ChAdOx1-S Complete COVID-19 COVID-19 pandemic elicit elicited exhibiting expressing form full-length humoral IgA IgG antibody Immunity immunization immunized immunized mice induce intramuscular intramuscular vaccination intramuscularly intranasal intranasally lung mice mucosa mucosal mucosal immunity neutralized neutralizing capacity percentage phenotype Prevent Protein robust SARS-CoV-2 sera spike the disease the Spike tissue vaccination Vaccine vaccine vectors. vectors virus entry [DOI] 10.1002/eji.202249823 PMC 바로가기 [Article Type] Article
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases Research Published on 2022-03-192022-10-05 Journal: Scientific Reports [Category] 치료제, [키워드] Aede Anophele Chloroquine condition DENV-2 derivative disease Effect effective Efficacy exhibited growth Host IC50 insecticidal lack malaria malarial mice Mosquito P. falciparum Plasmodium falciparum populations purified serotype Spread strain synthesis Toxicity vector vectors viral pathogen virucidal [DOI] 10.1038/s41598-022-08397-5 [Article Type] Research
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses Reviews Published on 2022-02-242022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 비임상, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses adjuvant age approach cellular contribute coronavirus Coronaviruses effective Efficacy environmental factor Factor failure Fighting Genetic geographical location heterogeneity humoral immune response Humoral immunity immune protection impair innate immune innate immune response innate immune system long-lived plasma cell mechanism memory T cell metabolite microbiome composition MOST pandemic SARS-CoV-2 Sex the SARS-CoV-2 Vaccine vaccine response Vaccines vectors [DOI] 10.1038/s41590-022-01130-4 [Article Type] Reviews
A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivaxArticle Published on 2022-02-092024-08-28 Journal: FEMS Microbiology Reviews [Category] 말라리아, [키워드] colonization comparative and population genomics host switch Local adaptation malaria vectors
Avian Orthoavulavirus Type-1 as Vaccine Vector against Respiratory Viral Pathogens in Animal and HumanReview Published on 2022-02-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adaptive immune response animal avian orthoavulaviruses type-1 expression feature Genes Genome Host hosts Human humans include lack limitation mammalian mammalian cell mammals membrane mitigations strategies offer pre-existing immunity protocol Recombination respiratory Respiratory pathogens robust safety profile transitioned unique Vaccine vaccine antigen Vaccines vector vectors viral pathogen virus [DOI] 10.3390/vaccines10020259 PMC 바로가기 [Article Type] Review
Strong SARS-CoV-2 N-Specific CD8 + T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice강력한 SARS-COV-2 N- 특이 적 CD8 + T 면역에 의해 유도 된 세포 외 소포에 의해 유도 된 면역은 마우스에서 치명적인 감염으로부터 보호됩니다.Article Published on 2022-02-062022-09-10 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] airways anti-SARS-CoV-2 vaccine antibody waning Antigen Associate Bronchoalveolar lavage fluid CD8 CD8+ T cell immunity cells characterized Combination described distribution DNA dose Efficacy Efficiency Evidence EVs expected expressing extracellular vesicle Extracellular vesicles fused highest idea immune memory immune response Immunity immunization immunized mice induce induced injection Intramuscular injection lethal lethal doses limitation Localization long-lasting lung Lungs Lymphocytes memory cell mice N-terminus Nef percentage platform prophylactic strategy protection Protein remained SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection spleen Strong T cell T cells T lymphocyte T lymphocytes target tissue Vaccines variants vector vectors Viral viral variant Viral variants were infected [DOI] 10.3390/v14020329 PMC 바로가기 [Article Type] Article
Compressed feature vector-based effective object recognition model in detection of COVID-19Short communication Published on 2022-02-012022-10-05 Journal: Pattern Recognition Letters [Category] 치료기술, [키워드] Accuracy adopted age approach build Characteristics classifiers complex computation conducted COVID-19 COVID-19 patient datasets dimension dimensions effective Efficiency epidemiological Factor Gender IMPROVE independent variables inefficient information object raise reduce reduction subject Support SVM vector vectors [DOI] 10.1016/j.patrec.2021.12.016 [Article Type] Short communication
Nosocomial Transmission of SARS-CoV-2 Involving Vaccinated Health Care WorkersObservation Published on 2022-01-052022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] COVID-19 COVID-19 vaccination effective epidemiological event events Genomics HCW HCWs Health information Involving measure Measures nosocomial outcome Patient patients prevaccination reported SARS-CoV-2 SARS-CoV-2 transmission Sequencing supported symptomatic disease Transmission vaccinated individual vaccination vector vectors Viral genome sequencing whole genome worker [DOI] 10.1128/spectrum.01532-21 PMC 바로가기 [Article Type] Observation
Vector composition, abundance, biting patterns and malaria transmission intensity in Madang, Papua New Guinea: assessment after 7 years of an LLIN-based malaria control programme벡터 조성, 풍부도, 물림 패턴 및 파푸아뉴기니 마당에서의 말라리아 전파 강도: LLIN 기반 말라리아 통제 프로그램 7년 후 평가Research Published on 2022-01-052024-08-08 Journal: Malaria Journal [Category] 말라리아, [키워드] abundance Anopheles Composition malaria mosquitoes Transmission vectors [DOI] 10.1186/s12936-021-04030-4 PMC 바로가기 [Article Type] Research