Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses코로나19 입원 환자를 위한 렘데시비르 및 기타 3가지 약물: WHO 연대 무작위 시험의 최종 결과 및 업데이트된 메타 분석Meta-Analysis Published on 2022-05-212022-09-11 Journal: Lancet (London, England) [Category] 신약개발, 임상, 치료제, [키워드] 1:1 allocation Analysis antiviral drugs assigned average both groups Characteristics Compliance controls country COVID-19 COVID-19 diagnosis database death died discharge discharged disease severity drug drugs eligible patient Endpoint enrolled exclusion Final futility hospital Hospital mortality hospitalised hospitalised patient Hospitalised patients Hydroxychloroquine in both groups in-hospital mortality Inpatient Inpatients interferon ISRCTN Kaplan-Meier Local Lopinavir meta-analyses Meta-analysis Mortality mortality analysis mortality rate ratio no significant effect occurred Open-label outcome oxygen participant Patient patients patients with COVID-19 Placebo placebos primary endpoint progressed progression proportion randomisation Randomised trial Randomly rate ratio receive recruited regions Registered Remdesivir reported secondary Secondary endpoints solidarity Solidarity trial Standard of care study drug the WHO treatment period Trial Ventilated Ventilation were given WHO [DOI] 10.1016/S0140-6736(22)00519-0 PMC 바로가기 [Article Type] Meta-Analysis
Detection of SARS-CoV-2 in the Indoor and Outdoor Areas of Urban Public Transport Systems of Three Major Cities of Portugal in 20212021년 포르투갈의 3개 주요 도시의 도시 대중 교통 시스템의 실내 및 실외 영역에서 SARS-CoV-2 감지Article Published on 2022-05-132022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] Air sampling Airborne transmission ambient analyzed Area be positive city collected Compact Concentration COVID-19 detection environmental contamination high risk indoor air Major Mask Masks microbial outdoor air. performed Portugal positive Public public transport risk of infection RT-qPCR Sample SARS-CoV-2 SARS-CoV-2 RNA swabs System Topic Transmission transmission of SARS-CoV-2 Transport urban Ventilated [DOI] 10.3390/ijerph19105955 PMC 바로가기 [Article Type] Article
Lung Response to a Higher Positive End-Expiratory Pressure in Mechanically Ventilated Patients With COVID-19Clinical Trial Published on 2022-04-012022-10-04 Journal: Chest [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Airway Pressure ARDS Compliance coronavirus disease Coronavirus disease 2019 COVID-19 CT scan decrease defined Endotracheal intubation exceeded Hyperinflation IMPROVE increase in lung lung recruitment mechanical ventilation Oxygenation Patient patients with ARDS PEEP Positive end-expiratory pressure pressure recruitment response Supine position Trial Ventilated ventilatory Volume were measured [DOI] 10.1016/j.chest.2021.10.012 PMC 바로가기 [Article Type] Clinical Trial
Ivermectin administration is associated with lower gastrointestinal complications and greater ventilator-free days in ventilated patients with COVID-19: A propensity score analysisResearch article Published on 2022-04-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI 95% confidence interval administration Admission antiparasitic drug assigned Clinical outcome Control COVID-19 COVID-19 patient COVID-19 patients diarrhea digestive Effect evaluate evaluated Gastrointestinal gastrointestinal complication Gastrointestinal symptom greater hazard ratio ICU incidence intensive care unit Ivermectin logistic regression model mechanical ventilation mechanically ventilated nasal tube Odds ratio outcome Patient prevention Probability propensity score analysis Regression model reported Result severe COVID-19 patient Symptom Ventilated ventilated patient ventilator-free day Ventilator-free days Weighting with COVID-19 [DOI] 10.1016/j.jiac.2021.12.024 [Article Type] Research article
Protocol summary and statistical analysis plan for I ntensive N utrition T herapy compar E d to usual care i N cri T ically ill adults (INTENT): a phase II randomised controlled trial집중 영양 치료에 대한 프로토콜 요약 및 통계 분석 계획과 일반 치료 비교 중환자(INTENT): 2상 무작위 대조 시험Article Published on 2022-03-082022-09-11 Journal: BMJ Open [Category] 임상, [키워드] adult intensive & Alfred Hospital analysed anticipated approval bloodstream Care conducted Controlled trial Critical Critical care Critically ill critically ill adult patients Critically ill patient critically ill patients Department determine dietetics disability Ethics ethics committee exclusion criteria feasible greater hospital hospital discharge Hospital stay Human Human Research Ethics Committee ICU include Inclusion infection rate Intensive intensive care intensive care unit intention-to-treat basis International Intervention media multicentre New Northern Territory nutrition nutrition & nutrition care Nutrition therapy nutritional support occur organ Organ failure organ system outcome outcomes parallel-group participant Patient peer-reviewed Primary outcome Protein randomisation randomised randomised controlled trial RCT receive recruited recruitment registration number rehabilitation rehabilitation medicine Research Ethics Result Sample size secondary Secondary outcomes social media Statistical analysis plan study period system failure therapy treat Trial usual care Ventilated Ventilation ventilator Ventilator-free days [DOI] 10.1136/bmjopen-2021-050153 PMC 바로가기 [Article Type] Article
3D modelling and simulation of the dispersion of droplets and drops carrying the SARS-CoV-2 virus in a railway transport coachArticle Published on 2022-03-072022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] accounted approach carried CFD Computational fluid dynamics coughing Critical distribution droplet droplets Engineering evaluate Face mask feasibility Health care infectious agents Mathematics and computing offer outcome pandemic physically recommendation Release seated secretion the SARS-CoV-2 virus Transmission Transport variety Ventilated Ventilation virus while [DOI] 10.1038/s41598-022-08067-6 PMC 바로가기 [Article Type] Article
Comparative outcomes of combined corticosteroid and remdesivir therapy with corticosteroid monotherapy in ventilated COVID-19 patientsResearch Article Published on 2022-02-232022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 48 hour all-cause mortality all-cause mortality rate analyzed Clinical improvement Cohort cohorts combination therapy Comparative conducted Corticosteroid COVID COVID-19 COVID-19 patient COVID-19 patients Cox proportional hazard Critically ill Efficacy groups hazard Hospitalized IMPROVE in-hospital mortality incidence Infection infections Kaplan-Meier Length log-rank test LOS monotherapy MRSA network Observational cohort study on mechanical ventilation outcome oxygen support Patient Primary outcome propensity score matching Pseudomona PSM Ratio RDV reduce reducing Remdesivir requiring supplemental oxygen secondary significant decrease Staphylococcus aureus stratified survival therapy Ventilated ventilatory support with COVID-19 [DOI] 10.1371/journal.pone.0264301 PMC 바로가기 [Article Type] Research Article
The presentation, course and outcome of COVID-19 infection in people with Prader-Willi syndrome: unexpected findings from an international surveyResearch Published on 2022-02-212022-10-29 Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Adults Affect age asked asymptomatic infection BMI children Cohort Complete conditions Course COVID-19 COVID-19 infection Diabetes Mellitus died disorder dry cough Effect Evidence family FIVE Genetic hospital Hypothesis hypothesised illness incidence Innate immunity intensive care International Length less mild illness obese obesity organization outcome outcomes over oxygen pandemic parent Prader-Willi syndrome presenting symptom professional promoted questionnaire raised respiratory disorders response Result Sex significantly supplementary material supported Symptoms temperature underlying condition Ventilated viral infection viral infections [DOI] 10.1186/s13023-022-02228-6 PMC 바로가기 [Article Type] Research
The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID studyObservational Study Published on 2022-02-152022-10-04 Journal: Aging (Albany NY) [Category] 임상, [키워드] Acute kidney injury age Analysis analyzed association Clinical outcome Cohort Compliance Complication complications Coronavirus disease 2019 COVID-19 Critical care Critically ill driving Endpoint four group had no hospital Hypoxemia ICU invasive ventilation management Mortality Myocardial infarction National Netherlands normalized outbreak outcome parameter parameters Patient patients performed positive predicted quartiles Respiratory system secondary Therapies therapy Ventilated Ventilation ventilator ventilator parameters Volume [DOI] 10.18632/aging.203863 PMC 바로가기 [Article Type] Observational Study
Tracheostomy timing and clinical outcomes in ventilated COVID-19 patients: a systematic review and meta-analysisResearch Published on 2022-02-082022-11-01 Journal: Critical Care [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 95% CI 95%CI association calculated Clinical outcome comparable conducted COVID-19 COVID-19 pandemic COVID-19 patient cumulative database defined Duration evaluate group ICU implication IMPROVE IMV intensive care unit Invasive mechanical ventilation less Meta-analysis mortality rate Odds ratio outcomes overall mortality Patient performed Primary outcome protocol random-effects model reductions in Registered reported Respiratory failure Result searched square supplementary material systematic review the mean tracheostomy Ventilated [DOI] 10.1186/s13054-022-03904-6 PMC 바로가기 [Article Type] Research