Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors강력한 SARS-CoV-2 3CL 프로테아제 억제제로서의 비스테로이드성 소염제 및 관련 유도체의 클로로피리디닐 에스테르Article Published on 2021-09-242022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] 3CL 3CLpro 3CLpro inhibitors active site agent Analysis Antiviral antiviral activity carboxylic acid characterized Compound covalent bond covalent inhibitors COVID-19 derivative EDC enzyme ester evaluated exhibited gel ibuprofen ibuprofen derivative in vitro indomethacin indomethacin derivative inhibitor inhibitory activity mode molecular Nonsteroidal potent protease purified Quantitative RdRP RdRp inhibitor Remdesivir salicylic acid salicylic acid derivative SARS-CoV-2 silica silica gel spectral analysis suggested synthesis VeroE6 cells [DOI] 10.3390/molecules26195782 PMC 바로가기 [Article Type] Article
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2Imatinib의 전임상 평가는 SARS-CoV-2에 대한 항바이러스제로 사용을 지지하지 않습니다.Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral activity antiviral drug antivirals clinical trial clinical trials Concentration coronavirus COVID-19 described drugs effective evaluated Hematological malignancies Human airway epithelium Imatinib impair inactive indicated initiated Kinase inhibitor kinase inhibitors lung masitinib pathogenic coronaviruses plasma Preclinical reconstructed Safe SARS-CoV-2 SARS-CoV-2 replication Support therapy TKI TKIs Treatment tyrosine tyrosine kinase inhibitor VeroE6 cells [DOI] 10.1016/j.antiviral.2021.105137 PMC 바로가기 [Article Type] Article
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection헤스페리딘은 SARS-CoV-2 감염에 대한 잠재적 억제제입니다Article Published on 2021-08-162022-09-10 Journal: Nutrients [Category] MERS, SARS, 변종, [키워드] 501Y.V2 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aglycone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bioavailability cellular cellular entry cellular receptor coronavirus D614G docking hesperetin hesperidin Infection Interaction metabolite Particles Potential Proteins reducing reduction required respiratory S protein SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus shown suppressed the S protein the SARS-CoV-2 TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor transmembrane serine protease transmembrane serine protease 2 variants variants of SARS-CoV-2 VeroE6 cell VeroE6 cells wild type [DOI] 10.3390/nu13082800 PMC 바로가기 [Article Type] Article
In vitro efficacy of artemisinin-based treatments against SARS-CoV-2Article Published on 2021-07-162022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] 50% effective concentration acute respiratory syndrome Anti-malarial drugs antiviral efficacy Antiviral treatment approved Artemisinin assays calculated Cancer caused Cell cells clinical Compound coronavirus coronavirus disease COVID-19 Drug discovery Efficacy evaluate experiment hepatoma Huh7.5 cell human lung immunostaining in vitro ingredient inhibited Patient peak plasma concentration required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein therapeutic window these compound Treatment utility VeroE6 cells viability viral infection [DOI] 10.1038/s41598-021-93361-y PMC 바로가기 [Article Type] Article
Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoformSARS-COV-2 감염에서 L-DOPA 데카르 복실 라제 발현의 변경 및 인터페론-유도 성 ACE2 이소 형과의 연관성Research Article Published on 2021-06-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 ACE2 expression alteration analyzed antiviral response association cell death cell population co-expressed correlated correlation COVID-19 COVID-19 patient COVID-19 patients cultured virus DDC Effect elevated ENCODE enrichment epithelial cells EPO evaluated expression favor Gene Expression Host host gene expression hours post-infection hypoxia in viral individual individuals infected cells infected individuals infections Influenza influenza-infected patients interferon interferon-stimulated gene isoform L-DOPA mild symptoms mRNA level mRNA levels nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples negatively affected non-infected Patient qPCR quantified receptor Regulation RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 virus SARS-CoV-2-infected cells SARS-CoV-2-infected individuals significantly statistically significant subjects suppresse the SARS-CoV-2 tissue VeroE6 cells Viral viral infection viral infections Viral load virus while whole blood sample [DOI] 10.1371/journal.pone.0253458 PMC 바로가기 [Article Type] Research Article
Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assaysRT-PCR 진단 분석에 적합한 구아니듐 기반 운송 배지를 사용하여 타액에서 SARS-Cov-2 바이러스의 불 활성화Research Article Published on 2021-06-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] 1:1 abrogated buffer Cell culture chain Chain Reaction clinical sample clinical samples condition conditions Copan COVID-19 CPE Cytopathic effect detect detectable diagnostic Dilution downstream evaluated expand guanidinium hazard inactivated inactivation Incubation infectious limit of detection log media medium minute passages positive processing reaction remained respiratory respiratory sample Result room temperature RT-PCR Saliva sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 virus stability temperature tested Transport upper VeroE6 cell VeroE6 cells Viral Viral RNA virus [DOI] 10.1371/journal.pone.0252687 PMC 바로가기 [Article Type] Research Article
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replicationSARS-Cov-2 뉴클레오캡시드 단백질의 아르기닌 메틸화는 RNA 결합, 스트레스 과립 형성 억제 능력 및 바이러스 복제를 조절합니다Research Article Published on 2021-05-232022-09-10 Journal: The Journal of Biological Chemistry [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 AP, affinity-purification arginine arginine methylation assembly binding blocked cancer treatment Cell culture clinical trial clinical trials component condensate coronavirus CTD, C-terminal dimerization domain defined DMSO, dimethylsulfoxide dose-dependent manner drugs FBS, fetal bovine serum Flag-N, Flag-epitope N protein G3BP1 genomic RNA GSK-3, glycogen synthase kinase 3 HEK293 cells hnRNPA1, heterogeneous nuclear ribonucleoprotein A1 host antiviral response host protein inhibited inhibiting inhibitor inhibitors Interaction life cycle lysine MERS-CoV, Middle East respiratory syndrome coronavirus methylarginine methylated Methylation methyltransferase motifs N protein N, nucleocapsid NTD, N-terminal RNA-binding domain nucleocapsid (N) protein nucleocapsid protein PAR-CLIP, photoactivatable ribonucleoside–enhanced crosslinking and immunoprecipitation PFA, paraformaldehyde PRMT1 PRMTs, protein arginine methyltransferases property Protein protein 3 RBP, RNA binding protein reduced regulate regulated required residue residues respiratory RGG/RG motif RIP, RNA immunoprecipitation RNA RNA binding S, spike SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequences severe acute respiratory syndrome Coronavirus SGs, stress granules significantly SMN, survival of motor neuron SR, serine/arginine-rich SRPK, SRSF protein kinase Stage Stress stress granule stress granules Substitution substrates suppress TDRD3, Tudor domain-containing protein 3 the N protein therapeutic Treatment Type type I type I PRMT inhibitor VeroE6 cell VeroE6 cells Viral viral genome viral life cycle Viral protein Viral proteins viral replication virion virions vRNP, viral ribonucleoprotein [DOI] 10.1016/j.jbc.2021.100821 PMC 바로가기 [Article Type] Research Article
Network medicine framework for identifying drug-repurposing opportunities for COVID-19COVID-19에 대한 약물 용도 변경 기회를 식별하기 위한 네트워크 의학 프레임워크435 Published on 2021-05-112022-08-31 Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Algorithms approved approved drug approved drugs artificial intelligence best can not candidate capture clinical trial clinical trials clinically Compound Consensus coronavirus COVID-19 COVID-19 pandemic dataset de novo develop diffusion disease Diseases drug Drug repurposing drugs Effectiveness Efficacy evaluate expected human cell human cells identify infections Infectious diseases mechanism methodological Metrics network network medicine offer outcome pathogen Pathogens pathway Predictive Protein reduced respiratory SARS-CoV-2 screened screenings severe acute respiratory syndrome Coronavirus Significance Systems biology treat treatments for COVID-19 VeroE6 cells Viral viral infection [DOI] 10.1073/pnas.2025581118 PMC 바로가기 [Article Type] 435
Scutellaria barbata D. Don Inhibits the Main Proteases (M pro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionScutellaria barbata D. Don은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염의 주요 프로테아제(M pro 및 TMPRSS2)를 억제합니다Article Published on 2021-05-022022-08-31 Journal: Viruses [Category] SARS, 치료제, [키워드] Scutellaria barbata activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis applied approach Calu3 cellular component Compound compounds coronavirus coronavirus 2 creating derivative determine effective Effectiveness enzyme activities enzyme activity expressing followed by function identify Infection infection assays inhibited inhibiting inhibitory activity inhibitory effect Inhibitory effects involved literature review M pro mechanism pandemic Prevent protease Proteases pseudoparticle Replication respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) TMPRSS2 TMPRSS2 protease Treatment VeroE6 cell VeroE6 cells Viral viral pseudoparticles were assessed [DOI] 10.3390/v13050826 PMC 바로가기 [Article Type] Article
Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 CoronavirusSARS-CoV-2 코로나바이러스의 핵단백질을 표적으로 하는 NSAID 약물 나프록센의 항바이러스 특성Article Published on 2021-04-292022-09-10 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] active against addition anti-inflammatory drug anti-inflammatory properties Antiviral antiviral properties antiviral property Antiviral treatment binding Celecoxib clinical setting clinical study coronavirus COVID-19 demonstrated drug Drug repurposing epithelia evaluated fluorescence anisotropy form function infected cells Inflammation Influenza influenza A influenza A virus inhibited inhibitor molecular naproxen nucleoprotein oligomerization pandemic Paracetamol predicted Prevent property respiratory respiratory epithelium SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection scattering Standard of care Structure-based drug design targeting tested the SARS-CoV-2 VeroE6 cell VeroE6 cells Viral viral replication virus [DOI] 10.3390/molecules26092593 PMC 바로가기 [Article Type] Article