TREM2 + and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaquesarticle Published on 2023-04-062024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Infection SARS-CoV-2 viral infection viral pathogenesis [DOI] 10.1038/s41467-023-37425-9 PMC 바로가기 [Article Type] article
SARS-CoV-2 rewires host chromatinResearch Highlight Published on 2023-04-032024-09-05 Journal: Nature reviews. Microbiology [Category] update2024, [키워드] SARS-CoV-2 viral pathogenesis Virus-host interactions [DOI] 10.1038/s41579-023-00891-5 PMC 바로가기 [Article Type] Research Highlight
Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolatesarticle Published on 2023-03-232024-09-05 Journal: Nature Communications [Category] update2024, [키워드] SARS-CoV-2 viral pathogenesis [DOI] 10.1038/s41467-023-37059-x PMC 바로가기 [Article Type] article
Time Series Analysis of SARS-CoV-2 Genomes and Correlations among Highly Prevalent MutationsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Analysis arising caused characterized Cluster Clustering computational tool contribute coronavirus correlated correlation correlation coefficient COVID-19 Deleterious Effect effort Evolution Frequency Genome genomes Hierarchical hierarchical clustering identify imperative in viral Meta-analysis Mutation mutations negative correlation Neutral NSP2 Nsp3 nucleotide ORF3a protein P323L pandemic Pearson Pearson correlation performed positive Protein protein dynamics. Q57H RdRP replaced RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 isolate SARS-CoV-2 sequences Scientific community Sery shown similarity stabilizing effect statistical T85I These data time UTR viral evolution viral genomes viral pathogenesis viral replication viral strains wild type wild-type [DOI] 10.1128/spectrum.01219-22 PMC 바로가기
Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon SignalingArticle Published on 2022-09-282023-06-22 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] avian viruses Cell signaling duck influenza viruses interferons Reservoir host TRIM25 ubiquitination viral pathogenesis [DOI] 10.1128/jvi.00776-22 PMC 바로가기
Unique mutations in SARS-CoV-2 Omicron subvariants’ non-spike proteins: Potential impacts on viral pathogenesis and host immune evasionArticle Published on 2022-09-012022-11-16 Journal: Microbial pathogenesis [Category] SARS, 변종, [키워드] Accessory accessory proteins B.1.1.7 B.1.617.2 Beta Cell Characteristics circulating COVID-19 pandemic cumulative Delta dominant Effect effective element epistasis expression FIVE Gamma growth Host host protein immune evasion immune-evasion Impact inactivation Interaction knowledge M protein Mutation mutations natural killer Non-spike mutations non-structural protein NSP6 omicron ORF7b Orf9b outcome P.1 Potential Probability progeny Protein Proteins Region Replication responsible SARS-CoV-2 significant difference Subvariants survival transmission rate unique variant variants of concern variants of interest viral pathogenesis virulence virus VOCs [DOI] 10.1016/j.micpath.2022.105699 PMC 바로가기
The basis of mink susceptibility to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 밍크 감수성의 근거Review Published on 2022-09-012022-09-11 Journal: Journal of applied genetics [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals B.1.1.7 B.1.617.1 B.1.617.2 coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Cross-species infection Cross-species transmission D614G death rate disease Evolution highest Host host range Human humans Infection interact issue Minks Mutation Occurrence over Pathogens phenomenon possession Protein raise RBD receptor Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sequence Sequence alignment spike Spike protein susceptibility the receptor-binding domain Transmission variants Viral diseases viral pathogenesis viral pathogens virus Y453F [DOI] 10.1007/s13353-022-00689-w PMC 바로가기 [Article Type] Review
Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
Structural similarity-based prediction of host factors associated with SARS-CoV-2 infection and pathogenesisSARS-CoV-2 감염 및 발병과 관련된 숙주 인자의 구조적 유사성 기반 예측Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] Analysis Apoptosis axon guidance CASP3 CD4 CD4 degradation clathrin Clathrin-mediated endocytosis clathrin-mediated endocytosis. composed Degradation down-regulate eIF2a Endoplasmic reticulum endosome enriched pathway enrichment analysis ERGIC event Factor Factors Genome heme HOPS complex Host information inhibitor interferon IRF1 life cycle matrix protein mechanism medical intervention membrane occur organized pandemic Pathogenesis phosphorylate predicted proteasomal degradation Protein protein kinase protein-protein interaction public health replicate reveal RNA synthesis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling similarity T cell therapeutic intervention TP53 translational Transport UBA52 UBC Vesicle viral entry viral pathogenesis Viral protein virion assembly Virus life cycle [DOI] 10.1080/07391102.2021.1874532 PMC 바로가기 [Article Type] Article