Increased Mortality Among Persons With Symptomatic Coronavirus Disease 2019 (COVID-19) During the Period of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta Variant) Predominance: Alaska, November 2020-October 2021Article Published on 2022-10-032022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, [키워드] Alaska B.1.617.2 B.1.617.2 (Delta) coronavirus 2 coronavirus disease COVID-19 death Delta delta variant higher odd Increased Mortality mortality risk Period Person predominant respiratory risk SARS-CoV-2 symptomatic vaccination virulence virulence. [DOI] 10.1093/cid/ciac530 PMC 바로가기
Real-life Evidence of Lower Lung Virulence in COVID-19 Inpatients Infected with SARS-CoV-2 Omicron Variant Compared to Wild-Type and Delta SARS-CoV-2 PneumoniaArticle Published on 2022-10-012022-11-16 Journal: Lung [Category] COVID19(2023년), SARS, 변종, [키워드] adult subject ambient animal model ARDS better respiratory function blood gas analysis Comorbidities consolidation COVID-19 Delta described evidence of explain hospital Hospitalization Immunity in vitro Infection Inpatient Italy less Lineage Lower lower mortality lower risk lung parenchyma observation omicron other variant Pneumonia preliminary finding replication capacity respiratory airway Respiratory failure SARS-CoV-2 severe respiratory failure Turin variants of concern virulence virulence. wild type [DOI] 10.1007/s00408-022-00566-7 PMC 바로가기
A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and AttenuationArticle Published on 2022-09-232022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] applied attenuation bat-CoV contagiousness coronavirus Coronaviruses correlated CoV COVID COVID-19 demonstrated disorder enzyme greater Hard immune system implication intrinsic Long COVID lung membrane protein Nature nucleocapsid protein nucleoprotein observation omicron pangolin Particle PID predicted PROTECT Replication Saliva SARS-CoV-2 shell supported tissues transmissions variant Viral load virion virulence virulence. virus [DOI] 10.3390/biom12101353 PMC 바로가기
The Omicron Variant BA.1.1 Presents a Lower Pathogenicity than B.1 D614G and Delta Variants in a Feline Model of SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 치료기술, [키워드] addition B.1 B.1.1.529 B.1.617.2 body temperature cats clinical COVID-19 D614G death Delta delta variant disease severity distribution effective Evidence evidenced histologic Hospitalization immunization immunofluorescence increased risk Infection infections Infectious virus Inflammation inoculated less lethargic log Lower lung Lung pathology Mild Model mutated nasal nasal turbinate observation omicron Pathogenesis pathogenic pathogenicity Pneumonia Postinfection present reduced remained Replication SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant secretion significant increase South Africa Spread staining suggested susceptible TCID tissue tissue tropism variant Variant of concern. variants Viral load viral replication Viral RNA viral titer Viral variants Virological virulence virus virus [DOI] 10.1128/jvi.00961-22 PMC 바로가기
Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and OmicronArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] adaptive Alpha Antiviral Complete Degradation Delta dominant effective Evolution Face mask glycosylated inactivation independent induce Infection ingestion Mask mice mutations non-toxic omicron Omicron variant pandemic physical barrier Polymer reduction SARS-CoV-2 SARS-CoV-2 transmission Spike protein Spread surface Transmission Vaccine variant variants variants of concern viral genome viral membrane virion virulence virus VoC VOCs waning immunity [DOI] 10.1021/acs.biomac.2c00801 PMC 바로가기
Mutations in the nonstructural proteins of SARS-CoV-2 may contribute to adverse clinical outcome in patients with COVID-19Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Amino acid Clinical course Clinical outcome Cluster contribute COVID-19 enrolled FIVE genome sequence Infection mortality rate Mutation nonstructural protein Nsp15 Nsp3 oxygen flow rate Patient patients with COVID-19 positive Primary outcome required Result SARS-CoV-2 secondary outcome selective severity the disease the S protein two groups virulence were infected with COVID-19 [DOI] 10.1016/j.ijid.2022.05.010 [Article Type] Research article
Unique mutations in SARS-CoV-2 Omicron subvariants’ non-spike proteins: Potential impacts on viral pathogenesis and host immune evasionArticle Published on 2022-09-012022-11-16 Journal: Microbial pathogenesis [Category] SARS, 변종, [키워드] Accessory accessory proteins B.1.1.7 B.1.617.2 Beta Cell Characteristics circulating COVID-19 pandemic cumulative Delta dominant Effect effective element epistasis expression FIVE Gamma growth Host host protein immune evasion immune-evasion Impact inactivation Interaction knowledge M protein Mutation mutations natural killer Non-spike mutations non-structural protein NSP6 omicron ORF7b Orf9b outcome P.1 Potential Probability progeny Protein Proteins Region Replication responsible SARS-CoV-2 significant difference Subvariants survival transmission rate unique variant variants of concern variants of concern. variants of interest viral pathogenesis virulence virus VOCs [DOI] 10.1016/j.micpath.2022.105699 PMC 바로가기
Identification of the binding interactions of some novel antiviral compounds against Nsp1 protein from SARS-CoV-2 (COVID-19) through high throughput screening고처리량 스크리닝을 통한 SARS-CoV-2(COVID-19)의 Nsp1 단백질에 대한 일부 신규 항바이러스 화합물의 결합 상호작용 확인Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 40S Analysis Antiviral compound bind binding affinity binding interaction Cell ChEMBL complexes COVID-19 docking drug designing drug library effective Factors human host identification in-silico Ligand ligands molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations nsp1 predict Protein Proteins responsible ribosomal subunit RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 SARS-CoV-2 pandemic screened Spike protein spreading tested the spike protein Treatment Virtual screening virulence virulence factor virulence factors. virus [DOI] 10.1080/07391102.2021.1887763 PMC 바로가기 [Article Type] Article
Non-neutralizing antibodies: Deleterious or propitious during SARS-CoV-2 infection?중화되지 않는 항체: SARS-CoV-2 감염 시 해롭거나 이롭습니까?Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ADE antibodies antibody Antibody-dependent enhancement Clinical course complex Course COVID-19 COVID-19 disease COVID-19 severity disease disease severity Diseases Epidemics Infection Infectious diseases involved mechanism Neutralizing antibodies pathogen Pathogens potential risk Reinfection responsible SARS-CoV-2 severe COVID-19 disease severity Support the disease Therapies thought vaccination Vaccines. virulence with COVID-19 worsening [DOI] 10.1016/j.intimp.2022.108943 PMC 바로가기 [Article Type] Review
Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesisArticle Published on 2022-08-242022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect Alter antibodies antibody binding binding affinity calculated cells change changes changes in Characteristics complexes contagious COVID-19 pandemic distribution docking domain drug design electrostatic electrostatic interaction ENhance entry of SARS-CoV-2 epitope hACE2 HSPGs human Angiotensin-converting enzyme hypothese Hypothesis immune evasion Invasion involved molecular mechanism mutant Mutation mutations neutralizing antibody occurred omicron pathophysiological Point mutation positive Protein Proteoglycan RBD RBD mutation RBD mutations residue S protein S trimer SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 variants strain surface the RBD Therapies Vaccine development variant variant strain. viral fitness viral infectivity virulence virus virus receptor [DOI] 10.3389/fpubh.2022.952916 PMC 바로가기