The emergence of the tetrathionate reductase operon in the Escherichia coli/Shigella pan-genomearticle Published on 2022-12-312024-09-01 Journal: MicrobiologyOpen [Category] 세균성이질, [키워드] Escherichia coli pathogen Shigella tetrathionate respiration virulence factor [Article Type] article
Identification of the binding interactions of some novel antiviral compounds against Nsp1 protein from SARS-CoV-2 (COVID-19) through high throughput screening고처리량 스크리닝을 통한 SARS-CoV-2(COVID-19)의 Nsp1 단백질에 대한 일부 신규 항바이러스 화합물의 결합 상호작용 확인Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 40S Analysis Antiviral compound bind binding affinity binding interaction Cell ChEMBL complexes COVID-19 docking drug designing drug library effective Factors human host identification in-silico Ligand ligands molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations nsp1 predict Protein Proteins responsible ribosomal subunit RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 SARS-CoV-2 pandemic screened Spike protein spreading tested the spike protein Treatment Virtual screening virulence virulence factor virulence factors virus [DOI] 10.1080/07391102.2021.1887763 PMC 바로가기 [Article Type] Article
Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Modelarticle Published on 2022-07-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] BgaA Coagulation neutrophil Streptococcus pneumoniae virulence factor [Article Type] article
Synergistic interactions of repurposed drugs that inhibit Nsp1, a major virulence factor for COVID-19COVID-19의 주요 독성 인자인 Nsp1을 억제하는 용도 변경 약물의 시너지 상호 작용Article Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, 치료제, [키워드] C-terminal Combination Compound COVID-19 Cytopathic effect expressed functional inhibit inhibited Interaction lung cells Montelukast Multiple Mutation nsp1 Ponatinib Protein Repurposed drug reversed Rilpivirine SARS-CoV-2 genome significantly synergistic the SARS-CoV-2 genome toxic effect toxic effects treat Virtual screening virulence virulence factor was used [DOI] 10.1038/s41598-022-14194-x PMC 바로가기 [Article Type] Article
Motility of the Zoonotic Spirochete Leptospira : Insight into Association with PathogenicityReview Published on 2022-02-072023-05-31 Journal: International Journal of Molecular Sciences [Category] Fulltext, 조류인플루엔자, [키워드] Bacteria Crawling flagella Leptospira leptospirosis motility Spirochete virulence factor [DOI] 10.3390/ijms23031859 PMC 바로가기 [Article Type] Review
Structural basis for the interaction of SARS‐CoV ‐2 virulence factor nsp1 with DNA polymerase α–primaseSARS -COV -2 독성 인자 NSP1과 DNA 폴리머 라제 α -Primase의 상호 작용을위한 구조적 기초Full‐Length Paper Published on 2021-11-122022-09-10 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding biochemical biochemical evidence causative agent complex component coronavirus coronavirus disease Coronavirus disease 2019 cryo‐EM DNA DNA polymerase DNA polymerase α–primase genomic host protein human protein human proteins immune response Infection Interaction interfere Microscopy molecular mechanism molecular mechanisms nonstructural protein 1 nsp1 PDB polymerase prevented protein–protein interaction proteomic purified recent reported respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 scrutiny severe acute respiratory syndrome Coronavirus target the disease Viral viral infection virulence virulence factor virus [DOI] 10.1002/pro.4220 PMC 바로가기 [Article Type] Full‐Length Paper
Pneumococcal Extracellular Serine Proteases: Molecular Analysis and Impact on Colonization and Disease폐렴구균 세포외 세린 프로테아제: 분자 분석 및 식민지 형성과 질병에 미치는 영향Article Published on 2021-11-012024-07-30 Journal: Frontiers in Cellular and Infection Microbiology [Category] 폐렴구균 감염증, [키워드] colonization Pathogenesis pneumococcal serine protease respiratory infection Streptococcus pneumoniae Structure virulence factor [DOI] 10.3389/fcimb.2021.763152 PMC 바로가기
High-Throughput Screening and Quantum Mechanics for Identifying Potent Inhibitors Against Mac1 Domain of SARS-CoV-2 Nsp3SARS-CoV-2 Nsp3의 Mac1 도메인에 대한 강력한 억제제를 식별하기 위한 고성능 스크리닝 및 양자 역학Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 치료제, [키워드] acceptor ADP-ribose ADP-ribosylation Against Antiviral antiviral activity binding binding pocket compounds conserved coronavirus CoV database docking domain Donor drug target electron donor ENCODE enzymatic activity enzyme host response identifying inhibitor inhibitors Interaction Mac1 Mechanics molecular dynamics mono nonstructural protein 3 Nsp3 other coronaviruses pathogenicity phosphate potent protein 3 provide quantum regions Regulatory residue ribose SARS-CoV-2 Screening substrate Tight binding unique viral infections virulence virulence factor Zinc [DOI] 10.1109/TCBB.2020.3037136 PMC 바로가기 [Article Type] Article
The Transcription Factor PfAP2-O Influences Virulence Gene Transcription and Sexual Development in Plasmodium falciparum전사 인자 PfAP2-O는 말라리아 원충 플라스모디움 팔시파룸의 병원성 유전자 전사 및 성적 발달에 영향을 미친다.Original Research Published on 2021-06-282024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antigenic variation epigenetic memory PfAP2-O VAR virulence factor [DOI] 10.3389/fcimb.2021.669088 PMC 바로가기 [Article Type] Original Research
Dual Role of Hydrogen Peroxide as an Oxidant in Pneumococcal Pneumonia폐렴구균 폐렴에서 산화제로서의 과산화수소의 이중 역할Article Published on 2021-04-202024-08-24 Journal: Antioxid Redox Signal [Category] 폐렴구균 감염증, [키워드] ARDS hydrogen peroxide pneumococci Pneumonia pyruvate oxidase virulence factor