virus spike protein – Page 2 – Communicable Diseases Research

SARS-CoV-2 Variants of Concern and Variants of Interest Receptor Binding Domain Mutations and Virus Infectivity

Immunology

Published on 2022-01-272022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein

자기 마이크로비드 친화성 선택 스크리닝의 발전: SARS-CoV-2 스파이크 단백질에 대한 천연 리간드의 발견

Article

Published on 2022-01-052022-09-11
Journal: Journal of the American Society for Mass Spectrome [Category] Coronavirus, SARS, 신약개발, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance affinity Amino acid amino acid sequence angiotensin Angiotensin converting enzyme-2 antibodies applied approaches binding caused complex coronavirus COVID-19 enzyme glycyrrhiza High-resolution HPLC human ACE2 human cell human cells include Interaction licochalcone a Ligand ligands Like mass spectrometry Microbead natural peptide pharmacological Prevent Protein subunit receptor robotics S1 protein SARS-CoV-2 SARS-COV-2 infection Selection sensitivity sequence severe acute respiratory syndrome Coronavirus small molecule Small molecules spike Spike protein subunit Tandem mass spectrometry targets the S1 protein the SARS-CoV-2 therapeutic agent therapeutic agents throughput treat virus spike protein
[DOI] 10.1021/jasms.1c00318 PMC 바로가기 [Article Type] Article

David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors

데이비드 대 골리앗: 잠재적인 SARS-CoV-2 억제제로서의 ACE2-Fc 수용체 트랩

Review

Published on 2022-01-012022-09-11
Journal: mAbs [Category] SARS, 변종,

[키워드] ACE2 ACE2-Fc administration affinity Affinity maturation angiotensin angiotensin-converting enzyme 2 antiviral activity avidity boost catalytic activity catalytic site COVID-19 DAVID Efficacy eliminated ENhance Evolution fusion Hospitalization immunoadhesins IMPROVE inhibitor intrinsic limit monoclonal antibodies monoclonal antibody mutations Neutralizing neutralizing antibody outbreak pandemic pharmacokinetics platform Point mutation point mutations receptor receptor traps. SARS Coronavirus SARS coronavirus 2 SARS-associated betacoronaviruses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown Spike protein suggested therapeutic therapeutic agent TRAP Vaccine viral burden viral escape virus spike protein
[DOI] 10.1080/19420862.2022.2057832 PMC 바로가기 [Article Type] Review

Computational study, synthesis and evaluation of active peptides derived from Parasporin-2 and spike protein from Alphacoronavirus against colorectal cancer cells

Cancer

Published on 2021-12-222022-10-28
Journal: Bioscience Reports [Category] Coronavirus,

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

SARS-CoV-2 변이체 중화 단일클론항체 개발 및 특성 규명

Article

Published on 2021-12-012022-09-11
Journal: Antiviral Research [Category] MERS, SARS, 변종, 진단,

[키워드] (Alpha) (Beta) administration Alpha Amino acid amino acid sequence Amino acid sequences antibody antigenicity B.1.1.7 B.1.351 B.1.617.2 Beta Broad-spectrum neutralizing mAbs candidate Candidates characterized COVID-19 COVID-19 therapy determined by development effective ELISA exhibited high-affinity binding immunoblot Infectious disease Infectious diseases Interaction mAb mAbs mass spectrometry monoclonal antibodies monoclonal antibody mouse monoclonal antibody neutralized Neutralizing P.1 Pandemics PRNT progression SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 spike protein Spike protein Support Therapies therapy Transmissibility Vaccine variant variant of concern (VOC) variants of concern Virus neutralization virus spike protein VoC
[DOI] 10.1016/j.antiviral.2021.105206 PMC 바로가기 [Article Type] Article

Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19

Pharmacology

Published on 2021-11-262022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE analyzed Anti-inflammation Antiviral binding Cell Characteristics Chinese clinical symptom clinical trials component Coronavirus disease 2019 COVID-19 dry cough Effects expected Fever glycyrrhizin immunomodulatory effects IMPROVE Inflammatory factor inflammatory mediator inhibit interfere licorice mechanism of action mechanisms Mild moderate molecular mechanism outbreak pandemic pathogenesis of COVID-19 pathway Patient pharmacological Pharmacological Effects Potential Prevent respiratory diseases Shortness of breath significant difference significantly stimulated suggested Symptoms target therapeutic Topic Traditional traditional uses treat Treatment type I interferon Vaccine virus spike protein
[DOI] 10.3389/fphar.2021.719758 PMC 바로가기 [Article Type] Pharmacology

A rapid, ultrasensitive voltammetric biosensor for determining SARS-CoV-2 spike protein in real samples

Article

Published on 2021-11-152022-11-16
Journal: Biosensors & bioelectronics [Category] 치료기술,

Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines

Research Article

Published on 2021-11-102022-10-30
Journal: Microbiology Spectrum [Category] COVID-19,

[키워드] age and gender antibodies antibody antibody kinetics Antibody Response average binding domain BNT162b2 BNT162b2 vaccine changes in clinically clinician Cohort COVID-19 COVID-19 pandemic defined difference dosage dose regimen elicited first dose Follow-up human cell IgG IgG antibody IgG response immune system immunization immunosuppressive drugs linear Moderna mRNA mRNA platform mRNA vaccine mRNA-1273 mRNA-1273 vaccine overcome participant peaked Pfizer/BioNTech powerful tool Prospective regimens regression modeling remained response S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconverted serological Serologically seronegative participants significantly higher Spike protein the SARS-CoV-2 the vaccine titer translated vaccination Vaccine Vaccines virus spike protein was used were measured
[DOI] 10.1128/Spectrum.01162-21 PMC 바로가기 [Article Type] Research Article

Relevance between COVID-19 and host genetics of immune response

Review article

Published on 2021-11-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘,

[키워드] 2019-nCoV ACE2 ACEAngiotensin Converting Enzyme Activation acute respiratory syndrome Affect allele frequency Alter alveolar angiotensin angiotensin converting enzyme Antigen presentation antigenic antigenic peptide association binding caused CD4+ CD8+ cellular immunity change changes in China complications coronavirus disease COVID-19 cytokine secretion death disease Endoplasmic reticulum expressed expression expression data expression level Gas exchange gene product Genes Genetic Genotype HBVHepatitis B virus HCVHepatitis C virus Hepatitis B virus hepatitis C virus high mortality highlight HIVhuman immunodeficiency virus HLA HLA class I HLA gene HLAHuman leukocyte antigen host genetics Human immunodeficiency virus human leukocyte antigen immune immune response impair Infection Lungs MHC class I Non-small cell lung carcinoma NSCLCNon-small cell lung carcinoma outbreak pathogen Pathogenesis peptide phenotype pneumocyte Pneumocytes polymorphism populations precursor present antigen progression RASRenin-angiotensin system Relevance renin-angiotensin system reported responsible resulting SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARSSevere Acute Respiratory Syndrome Severe acute respiratory syndrome severe hypoxia Single nucleotide polymorphism SNPSingle nucleotide polymorphism Spread susceptibility T lymphocytes T-cell responses T-cells variant Variation viral entry viral infection virus virus spike protein viruses Wuhan
[DOI] 10.1016/j.sjbs.2021.07.037 [Article Type] Review article

Does reactogenicity after a second injection of the BNT162b2 vaccine predict spike IgG antibody levels in healthy Japanese subjects?

Research Article

Published on 2021-09-202022-10-28
Journal: PLoS ONE [Category] COVID-19, SARS,