Evaluating correlates of protection for mix-match vaccine against COVID-19 VOCs with potential of evading immunityArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] appear Bayesian Beta ChAdOx1 Clinical efficacy Correlate of protection COVID-19 D614G Delta Delta VOC distribution Efficacy ENhance evaluate Evaluating finding Heterologous highlight homologous Immunity inversion Mix-match mRNA-1273 neutralizing antibody omicron pandemic phase 3 trial predicted Predictive previous study provide ranged reduction reductions in strain vaccination Vaccine variant Variant of concern. variants variants of concern VoC VOCs was used while Wuhan [DOI] 10.1016/j.vaccine.2022.10.011 PMC 바로가기
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamstersArticle Published on 2022-11-042022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] Antigen B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta block Community COVID-19 vaccine current Delta delta variant detectable Efficacy eliminating expressed Fever Gamma hamster immunization Lineage Lung pathology maintain Neutralizing antibody response omicron P.1 pandemic predominant Prevent PROTECT SARS-CoV-2 strains SARS-CoV-2 variant sequence Spread titre Transmission Vaccine variants variants of concern vectored vaccine virus VoC VOCs [DOI] 10.1038/s41467-022-34439-7 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Differences in environmental stability among SARS-CoV-2 variants of concern: both omicron BA.1 and BA.2 have higher stabilityArticle Published on 2022-11-012022-11-16 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] Beta calculated Characteristics Concentration contributing to Delta difference Disinfection Disinfection effectiveness Effectiveness Efficacy environmental stability evaluate evaluated Ex vivo exhibited Gamma in vitro inactivated Infection median omicron regression analysis risk SARS-CoV-2 SARS-CoV-2 variant Spread stability survival transmissibility of SARS-CoV-2 Transmission variant variants variants of concern virus Virus survival. virus titre VoC VOCs was determined were measured Wuhan Wuhan strain [DOI] 10.1016/j.cmi.2022.05.020 PMC 바로가기
Potential of antibody pair targeting conserved antigenic sites in diagnosis of SARS-CoV-2 variants infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of virological methods [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] antibody Antibody pair Antigen antigenic site antigenic sites binding domain candidate caused clinical samples Clusters complex conformational conserved Coronavirus disease 2019 COVID-19 COVID-19 pandemic demonstrated determine develop diagnosis of SARS-CoV-2 diagnostic early diagnosis ELISA Infection mAb mAbs monoclonal antibody pandemic Potential pseudovirus RBD RBD-specific mAbs recognizing residue SARS-CoV SARS-CoV S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S protein SARS-CoV-2 variant selected Sensitivity and specificity spike Spike antigen. Spike protein substitutions Treatment variant VOCs [DOI] 10.1016/j.jviromet.2022.114597 PMC 바로가기
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitorsArticle Published on 2022-11-012022-11-15 Journal: Nature chemical biology [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding component conserved coronavirus defined Diseases epitope Epitopes highlighting inhibitor inhibitors inhibitory linker monoclonal neutralize Neutralizing activity non-neutralizing antibody omicron pandemic receptor SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-CoV-2 variant target the SARS-CoV-2 Treatment viral spike protein VOCs [DOI] 10.1038/s41589-022-01140-1 PMC 바로가기
Development of multiplex S-gene-targeted RT-PCR for rapid identification of SARS-CoV-2 variants by extended S-gene target failureArticle Published on 2022-11-012022-11-15 Journal: Clinica chimica acta; international journal of cli [Category] SARS, 변종, 치료기술, 치료제, [키워드] binding caused codon concordance rate Delta development Epidemics genomic sequencing Internal control Japan multiplex Multiplex RT-PCR Mutation N-gene omicron probe Rapid Rapid screening Region RT-PCR S-gene S-gene mutations S-gene target failure SARS-CoV-2 SARS-CoV-2 variant screening method Sequencing time-consuming Variant of concern. VoC VOCs [DOI] 10.1016/j.cca.2022.08.031 PMC 바로가기
ColdZyme® protects airway epithelia from infection with BA.4/5Article Published on 2022-10-312022-11-16 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 변종, [키워드] Activation administration airway airway epithelia applied BA.4 BA.5 block blocked complement contagious Critical Culture epithelial in vitro data Infection Inflammation inflammatory reaction Intervention intrinsic omicron Pathogenesis prevented Prophylaxis PROTECT respiratory tissue SARS-CoV-2 SARS-CoV-2 transmission significantly subsequent Transmission variants variants of concern variants of concern. Viral transmission virus infection VoC VOCs while [DOI] 10.1186/s12931-022-02223-2 PMC 바로가기
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccinationArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antibody Response B.1.617.2 BAL Blood booster vaccination Breakthrough infection Bronchoalveolar lavage fluid cellular immunity circulating Combination convalescent COVID-19 COVID-19 vaccine D614G Delta demonstrated effective elicit hospitalized patients humoral immune response Immunity immunization individual induce Infection mRNA vaccination mucosal neutralizing antibody Neutralizing antibody response neutralizing antibody responses offer omicron Reinfection respiratory respiratory tract response robust SARS-CoV-2 severe disease significantly lower Support T cell T cell response the SARS-CoV-2 vaccinated individuals variant variants of concern virus VOCs with COVID-19 [DOI] 10.1126/sciimmunol.add4853 PMC 바로가기