wall – Page 2 – Communicable Diseases Research

Abdominal Surgery in Patients With COVID-19: Detection of SARS-CoV-2 in Abdominal and Adipose Tissues

COVID-19 환자의 복부 수술: 복부 및 지방 조직에서 SARS-CoV-2 검출

Case Reports

Published on 2020-09-012022-09-11
Journal: Annals of surgery [Category] SARS, 치료기술,

A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein

점 돌연변이는 마이크로솜 트리글리세리드 전달 단백질의 지질 전달 활동을 분리합니다

Research Article

Published on 2020-08-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect ApoB ApoB-containing lipoprotein ApoB-containing lipoproteins Apolipoprotein B Apolipoprotein B-containing lipoprotein Apolipoprotein B-containing lipoproteins assembly B-lp B-lps bind block blood vessels cardiovascular cardiovascular disease circulation complex conserved Critical crystal structure cytoplasmic lipid droplet cytoplasmic lipid droplets disease Disruption drug design dyslipidemia dyslipidemias Embryo endogenous lipid fat malabsorption feasible G863V G863V mttp mutant protein G863V mutant protein glycine growth growth defects growth retardation growth retardation) health condition heterodimeric highlight Human human MTP humans hydrophobic identify inhibitor insect Insects intestinal fat malabsorption L475P Lipid lipid transfer activity lipids Lipoproteins metabolism microsomal triglyceride transfer protein Missense mutation modeling morphology Mtp MTP complex MTP triglyceride transfer activity MTTP mutant mutants Mutation opacity phenotype Phospholipids plasma lipoproteins Point mutation power Prevent Protein reduce reported required residue secretion selective selective inhibition Support synthesis Therapeutic approach These data tissues transfer Transport treat Triglyceride triglycerides valine vertebrates wall yolk yolk opacity yolk syncytial layer YSL zebrafish
[DOI] 10.1371/journal.pgen.1008941 PMC 바로가기 [Article Type] Research Article

Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다

Research Article

Published on 2017-03-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall
[DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article

PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C

PRO40은 MAP 키나제 모듈을 업스트림 활성제 단백질 키나제 C에 연결하는 세포벽 무결성 경로의 스캐폴드 단백질입니다.

Research Article

Published on 2014-09-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activator adapter adapters Affinity purification Alzheimer's disease approach ascomycete asexual development bind Cancer Cell cell differentiation Cell fusion cell wall characterized combating conserved Control deletion mutant deletion mutants determinant developmental developmental processe developmental processes disease domain ENCODE environmental cue environmental cues eukaryote eukaryotes eukaryotic Evidence experiment Extensive filamentous fungi fruiting bodies fungal fungi fungus Genetic growth homolog implicated integrity Interaction interaction partner involved kinase MAPK mass spectrometry mitogen mitogen-activated protein kinase module molecular MOST mutant mutated N-terminal Pathogenesis pathogenicity pathway Pathways Phosphorylation polar Protein protein kinase protein kinase C Regulation required scaffold protein Signal transduction Signaling Sordaria macrospora Stress stress response symbiosis the cell upstream vegetative growth wall yeast
[DOI] 10.1371/journal.pgen.1004582 PMC 바로가기 [Article Type] Research Article