Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 sACE2. SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article
Enzyme linked oligonucleotide assay for the sensitive detection of SARS-CoV-2 variantsArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, 치료기술, [키워드] antibody aptamer buffer condition conditions Delta delta variant detect detection Detection limit develop diagnostic effective elements ELONA human nasal fluid identify in vitro inactivated Modification predicted RBD reporter Research S glycoprotein S protein Sandwich SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant Screening SEM sensitivity Spike protein spread of COVID-19 stability TCID variant viral particle virus virus. was obtained was used Wuhan [DOI] 10.3389/fcimb.2022.1017542 PMC 바로가기
Assessing the impact of the four COVID-19 variants and the vaccine coverage on mortality in Malta over 2 years: An observational case studyArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Alpha variant Assessing center CFR contributed Control Coverage COVID-19 disease Disease burden dominant Effect Effectiveness European Factor highest Intervention Malta Ministry of Health Mortality Mutation omicron original pandemic Post-vaccine prevention reported target the vaccine Transmissibility vaccination vaccination rates vaccination. variant was obtained website Year [DOI] 10.3389/fpubh.2022.1018505 PMC 바로가기
Fluorine Atoms on C6H5-Corrole Affect the Interaction with Mpro and PLpro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR ApproachesArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] 2D-QSAR 3CL pro acute respiratory syndrome binding binding affinity Compound compounds coronavirus correlation corroles cysteine protease decrease derivative docking score evaluated fluorine in silico in vitro In vitro assay increase in indicated inhibitor insertions Interaction M pro molecular docking molecular docking. MPro NMR nuclear Papain-like protease parameter physical-chemical PLPro protease Quantitative Region SARS-CoV-2 SARS-CoV-2 replication separated target the binding affinity two-dimensional was obtained [DOI] 10.3390/ijms231810936 PMC 바로가기
Anthropogenic Sewage Water Circuit as Vector for SARS-CoV-2 Viral ARN Transport and Public Health Assessment, Monitoring and Forecasting-Sibiu Metropolitan Area (Transylvania/Romania) Study CaseArticle Published on 2022-09-172022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] Accuracy Area assessment can be used China circuit city coefficients collected Community correlated correlation correlation coefficient disease Effect Epidemics epidemiological feasibility Health help highlight increase in increases in Infection Local management monitoring occurred Pearson correlation Public quantified reported risk Risk assessment risk factor SARS-CoV-2 SARS-COV-2 infection sewage sewage water. Spread vector viral infection Viral pneumonia Viral RNA virus virus spread was measured was obtained wastewater water [DOI] 10.3390/ijerph191811725 PMC 바로가기
High Seroprevalence of SARS-CoV-2 in Mwanza, Northwestern Tanzania: A Population-Based SurveyArticle Published on 2022-09-162022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료기술, [키워드] African antibodies antibody blood sample cause Community conducted country COVID-19 cross-sectional survey Data analysis detect distribution enrolled Evidence Factors IgG IgG and IgM IgM and IgG interquartile range investigated loss of taste magnitude median age Mwanza occurred participant prevention protocol rapid test kit SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgM selected seropositive Seroprevalence seroprevalence. survey Tanzania the SARS-CoV-2 the SARS-CoV-2 virus Transmission understanding was obtained were used [DOI] 10.3390/ijerph191811664 PMC 바로가기
Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock-a two-centre randomised clinical trialRandomized Controlled Trial Published on 2022-09-052022-10-05 Journal: Critical Care [Category] 임상, [키워드] Acute kidney injury Adequate Adult patient antibiotic Antibiotics clinical Clinical decision support clinical trial control group COVID-19 pandemic Critically ill patient critically ill patients data-driven dose Efficacy eligible Endpoint EudraCT European evaluate faster feasibility feasible for inclusion ICU implementation IMPROVE incidence Inclusion increased mortality Infection intervention group Lactate Mortality Netherland not significantly different outcome patients personalised pharmacokinetic pharmacokinetics Primary outcome randomisation randomised Registered renal right Safe Sepsis Septic shock significantly Support Therapeutic Drug Monitoring Therapeutic drug monitoring. Trial was obtained [DOI] 10.1186/s13054-022-04098-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Detection of COVID-19 using deep learning techniques and classification methodsResearch article Published on 2022-09-012022-10-05 Journal: Information Processing & Management [Category] 진단, 치료기술, [키워드] Accuracy addition AUC value auxiliary can be used chain classification COVID-19 COVID-19 disease COVID-19 patient criteria database decision deep learning detection Diagnosis diagnosis of COVID-19 education evaluated examined feature forest Naive Baye PCR radiologist reaction reduce Resnet ROC Curve Spread Support support vector machine SVM the disease the patient Transmission tree was obtained [DOI] 10.1016/j.ipm.2022.103025 [Article Type] Research article
Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodiesArticle Published on 2022-09-012022-11-16 Journal: Clinical Cardiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Admission Analysis antibody Anticoagulant antiheart antibodies association Atherosclerosis Autoimmune average biopsy proven CD20 CD3 CD45 CD68 characterized chronic chronic heart failure Clinical sign Combination congestive heart failure Coronary coronavirus COVID-19 diagnosed Diagnosis diagnosis of COVID-19 edema Ejection fraction EMB Endocarditis Endomyocardial biopsy Endothelium eosinophilic myocarditis heart IgG IHC immune infective lymphocytic myocarditis Macrophage male mechanism Morphological Myocardial myocarditis New York nine nucleocapsid antigens Patient patients persistence polymerase chain post-COVID endocarditis post-COVID myocarditis RNA SARS-CoV-2 Seroconversion Symptom therapy thrombosis Treatment ventricular viral infection viral persistence viral persistence. was obtained [DOI] 10.1002/clc.23886 PMC 바로가기