Why Omicron Variant of SARS-CoV-2 is Less Fatal?SARS-CoV-2의 오미크론 변종이 덜 치명적인 이유는 무엇입니까?Article Published on 2022-07-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addressed Amino acid amino acids article biochemical build calcium calcium oxalate chloride Deleterious mutations ENhance glycine insoluble less lysine mechanism Mutation mutations omicron Omicron variant omicron variant. oxalate Protein public health question residue residues SARS-CoV-2 Substitution valine variant variant of SARS-CoV-2 weakened [DOI] 10.1002/cbic.202200158 PMC 바로가기 [Article Type] Article
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone [DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article
Modeling long-term impacts of the COVID-19 pandemic and oil price declines on Gulf oil economiesResearch article Published on 2022-07-012022-10-05 Journal: Economic Modelling [Category] 변종, [키워드] accelerate agreement applied COVID COVID-19 pandemic Critical Decline detrimental Economic sustainability Effect Efficiency energy Energy transition equilibrium Fiscal policy General equilibrium Government Gulf Impact implementation Kuwait Model modeling pandemic Paris potential benefits PROTECT reduce Resilience significantly subsequent targets waned weakened [DOI] 10.1016/j.econmod.2022.105849 [Article Type] Research article
Neutralising reactivity against SARS-CoV-2 Delta and Omicron variants by vaccination and infection history백신 접종 및 감염 이력에 의한 SARS-CoV-2 Delta 및 Omicron 변이체에 대한 반응성 중화Article Published on 2022-06-102022-09-11 Journal: Genome Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Abbott anti-S antibody antibody antibody persistence Antibody Response Antibody titre antibody titres Antigen B.1 B.1.1.529 B.1.617.2 blood sample Blood samples Cohort collected control group control groups controls COVID-19 cross-protective Delta delta variant DiaSorin dose elicited followed by generate group healthcare healthcare worker Immune escape Immunity immunoassays increasingly individuals induce Infection investigated N antigen naïve naïve subject naïve subjects natural infection neutralisation neutralising Neutralising Antibodies nucleocapsid omicron Omicron variant performed persistence Post-infection presence of antibody question reactivity required Roche S antigen SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants sera Serosurvey serum significantly subject subjects tested the SARS-CoV-2 timepoints two groups vaccinated individuals vaccination vaccination. Vaccine Vaccine development variant virus VoC VOCs weakened were used while [DOI] 10.1186/s13073-022-01066-2 PMC 바로가기 [Article Type] Article
Advanced Liver Fibrosis Correlates With Impaired Efficacy of Pfizer-BioNTech COVID-19 Vaccine in Medical Employees진행성 간 섬유증은 의료진에서 화이자-바이오엔텍 코로나19 백신의 효능 저하와 상관관계가 있습니다Article Published on 2022-06-012022-09-12 Journal: Hepatology communications [Category] MERS, 진단, [키워드] acute respiratory syndrome age booster calculated candidate center chronic liver disease coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccine displaying Efficacy employee Factor FIB-4 fibrosis Fibrosis-4 Gender General population hepatic fibrosis IgG IgG level IgG titer Immunoglobulin Immunosuppressed Impaired Increased individual Jerusalem male males offered Older age Pfizer-BioNTech provide Responder risk factor significantly subgroups Undetermined vaccination Vaccine Vaccine failure vaccine response weakened [DOI] 10.1002/hep4.1901 PMC 바로가기 [Article Type] Article
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다Article Published on 2022-06-012022-09-11 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] abrogated activated Activation acute respiratory syndrome coronavirus Analysis Asymptomatic COVID-19 ATP6AP1 ATPase autophagic flux binding caspase-1 coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated epithelial cells exhibited impair induce Infection Inflammasome inflammasome activation inflammasomes inflammatory cell Inflammatory cell death inhibit inhibited interleukin L37F live SARS-CoV-2 lung epithelial cell Lung epithelial cells lung tissues lysosome acidification maturation metformin Mutation NLRP3 non-structural protein NSP6 overexpression Patient pharmacological Polydatin proton pump pyroptosis receptor signaling reduced respiratory SARS-CoV-2 serological markers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 suggested Support Transcriptome transcriptome analysis Trigger triggered upstream vacuolar variant viral pathogenicity weakened [DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article
Does metformin affect outcomes in COVID-19 patients with new or pre-existing diabetes mellitus? A systematic review and meta-analysisReview Published on 2022-06-012022-10-04 Journal: British Journal of Clinical Pharmacology [Category] 신약개발, [키워드] adjusted Affect affected approach biguanides carried certainty cohort study coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient database diabete Diabetes Mellitus Effect Evidence exhibiting global public health glycaemic control highlight immune responses IMPROVE lower mortality Meta-analysis metformin Mortality Odds ratio outcome outcomes Patient patients with COVID-19 patients with diabete Poor Primary outcome Quantitative random-effect Randomised trial recent Registered reported risk of bia robust SARS-CoV-2 searched shown significantly systematic review Treatment type 2 diabetes type 2 diabetes. weakened Web of Science [DOI] 10.1111/bcp.15258 PMC 바로가기 [Article Type] Review
Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2SARS-CoV-2의 수용체인 카르복시펩티다제 ACE2의 동종효소인 B38-CAP의 결정 구조로 밝혀진 구조적 통찰력Article Published on 2022-05-282022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 carboxypeptidase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 B38-CAP carboxypeptidase catalysis catalytic coincidence complex interplay conformational flexibility coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crystal structure dimeric domain drugs enzyme feature Host Isoenzyme problem provide provided RAS receptor Renin renin-angiotensin system sACE2 SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2. severe acute respiratory syndrome Coronavirus specificity Structural analysis Treatment treatment of COVID-19 triggered variety weakened worldwide pandemic worsened [DOI] 10.1016/j.bbrc.2022.03.077 PMC 바로가기 [Article Type] Article
Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic AreasCOVID-19 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2 재조합 S 단백질, 수용체 결합 도메인 및 이의 수용체 결합 모티브의 혈청반응성과 말라리아 발병 지역의 코로나19 이전 샘플과의 교차 반응성Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age anti-S antibody antibody Antibody Response Antibody responses Antigen antigens Area Asthma blood sample Blood samples Community Comorbidities conducted coronavirus coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 samples cross-reactive antibody cross-reactivity determine diabete diabetes disease Donor ELISA full-length Gender hospital IgG antibodies IgG antibody individual malaria malaria endemic-area participant Patient Plasmodium falciparum Plasmodium falciparum infection Pre-COVID-19 samples Protein RBD RBM Receptor-binding domain receptor-binding motif Recognition Recombinant S regions respiratory response responses S protein Sample SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein sera seroreactivity. severe acute respiratory syndrome Coronavirus Study participants tested the receptor-binding domain the SARS-CoV-2 Treatment triggered weakened West while [DOI] 10.3389/fimmu.2022.856033 PMC 바로가기 [Article Type] Article
Voices from the Pandemic: A Qualitative Study of Family Experiences and Suggestions regarding the Care of Critically Ill PatientsObservational Study Published on 2022-04-012022-10-05 Journal: Annals of the American Thoracic Society [Category] 임상, [키워드] age analyzed approach Care clinician Clinicians communication Contact contributed coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Critical care Critically ill patient critically ill patients described early phase experience family family member female hospital ICU ICU patient Ill IMPROVE interview nine Observational cohort study offer offered pandemic participant Patient physical distancing physically postintensive care syndrome-family. Psychological Qualitative recommendation reduced Satisfaction Stress suggestion Support the mean thematic analysis therapeutic relationship transcribed understanding United State voice weakened with COVID-19 [DOI] 10.1513/AnnalsATS.202105-629OC PMC 바로가기 [Article Type] Observational Study