Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot studyArticle Published on 2022-11-012022-11-15 Journal: American journal of otolaryngology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adult patients Affect analyzed baseline chlorhexidine clinical collected COVID-19 detectable Disinfection effective Effectiveness groups Hospitalized hydrogen peroxide individual initial mouth negativity oral oral cavity Oral diseases Oral medicine Oral rinses Patient pilot study Placebo placebo-controlled Povidone‑iodine Public public health Randomized recruited reduced reducing Replication Research Saliva. SARS-CoV-2 SARS-CoV-2 viral load swab specimens the placebo group viral copy number were measured [DOI] 10.1016/j.amjoto.2022.103549 PMC 바로가기
Spike-specific T-cell responses in patients with COVID-19 successfully treated with neutralizing monoclonal antibodies against SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Administered analyzed CD4 CD8 cellular response Clinical outcome COVID-19 demonstrated effective evaluate Evolution flow cytometric group healthy controls immune memory Immunity Impact impair IMPROVE increases in individuals Infection initial investigated marker median memory memory T-cell response monoclonal antibodies monoclonal antibody neutralizing monoclonal antibody Patient patients patients treated patients with COVID-19 receiving SARS-CoV-2 significant increases in SOT spike statistically significant statistically significant difference T-cell Response T-cell response. treated Treatment Viral diseases were measured [DOI] 10.1016/j.ijid.2022.09.016 PMC 바로가기
Prevalence of antibodies against SARS-CoV-2 in the Norwegian population, August 2021Article Published on 2022-11-012022-11-15 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 진단, [키워드] absence age Anti-nucleocapsid antibodies antibody automatically children collected conducted confirmed COVID-19 case contributed COVID-19 COVID-19 case COVID-19 pandemic COVID-19 vaccination CrI cross-sectional cumulative estimate Estimated flow cytometric IgG antibody individual Infection Laboratory National Norway nucleocapsid nucleocapsid protein Prevalence RBD Receptor binding domain registry data residual SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence sera seropositive sample Seroprevalence the spike protein vaccination vaccination. were measured women [DOI] 10.1111/irv.13024 PMC 바로가기
Humoral and Cellular Immune Response to Covid-19 Vaccination in Patients with Chronic Graft-versus-Host Disease on ImmunosuppressionArticle Published on 2022-11-012022-11-15 Journal: Transplantation and cellular therapy [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome amplified anti-spike antibody antibody association cellular Characteristics chronic coronavirus COVID-19 COVID-19 vaccination demonstrated detect disease dose Efficacy enrolled Escalation evaluated group HCT humoral Humoral response immune immune response Immunosuppression immunosuppressive immunosuppressive therapy Infection initial management mononuclear cell natural infection neutralizing antibody Neutralizing antibody response neutralizing antibody titers Patient patient population patients Peripheral blood positive positive correlation present progression proportion Quantitative receiving Responder responders response Sample size SARS-CoV-2 sequence Significant statistical difference susceptibility T cell T cell receptor T cell response T cell responses the antibody response the patient therapy unique vaccination Vaccine vaccine. was measured were measured worsened worsening [DOI] 10.1016/j.jtct.2022.08.026 PMC 바로가기
SARS-CoV-2 antibody research in patients with unprovoked pulmonary embolism in COVID-19 pandemic periodArticle Published on 2022-11-012022-11-16 Journal: Journal of Thrombosis and Thrombolysis [Category] SARS, 치료기술, [키워드] addition antibody Antigen Asymptomatic COVID-19 asymptomatic patients checked Computed tomography consecutive patient coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic CTPA diagnosed Elderly patient had no Immunity increase in material pandemic participant Patient patients patients with comorbidity PE positive result pulmonary Pulmonary thromboembolism Research risk risk factor SARS-CoV-2 SARS-CoV-2 antibody serum sample significant increase the patient thrombosis Tomography. were measured [DOI] 10.1007/s11239-022-02703-8 PMC 바로가기
Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid Thyroid. tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE studyArticle Published on 2022-11-012022-11-15 Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘, [키워드] 28-day mortality adult COVID-19 patients Analysis Bacterial Bacterial sepsis Biomarker clinical outcomes Clinical severity Cluster Cohort conditions coronavirus disease Correlation analysis COVID-19 COVID-19 patient dimension disease disease entity dysfunction endothelial Endothelial dysfunction explained Health healthy control high mortality Hospitalized hospitals host response impairment independent intubation marker Microcirculation Microscopy Microvascular dysfunction microvascular injury outcome analysis outcomes overlap patients plasma plasma protein predict predictor Protein proteome proteomic Proteomic signature proteomics quantified sepsis. Variation was performed was used were measured were used [DOI] 10.1007/s10456-022-09843-8 PMC 바로가기
Serum neurofilament light chain levels in Covid-19 patients without major neurological manifestationsArticle Published on 2022-11-012022-11-15 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] absence Admission baseline Biomarker Blood Brescia C-reactive protein change controls correlated COVID-19 CRP D-dimer disease severity evaluated Evidence excluded explained fibrinogen healthy controls Hospital stay Hospitalized hypoxic Increased longitudinal measure Neuroaxonal damage neurofilament Neurofilament light chain (NFL) neurological manifestation neurological manifestations neurotoxic PaO2/FiO2 ratio parameters Patient patients plasma promote reported respiratory respiratory impairment SARS-CoV-2 scale serum serum creatinine serum CRP Serum level serum sample serum. significantly Simoa systemic inflammation Variation were measured White blood cell with mild disease [DOI] 10.1007/s00415-022-11233-5 PMC 바로가기
COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective, case-control studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Gastroenterology & Hepatology [Category] SARS, 진단, [키워드] adjusted age All participant anti-SARS-CoV-2 anti-TNF antibody Antibody binding antibody concentration Antibody concentrations approved available data boost booster case-control study combination therapy Concentration control group COVID-19 COVID-19 vaccine Diagnosis disease dose Evidence first dose geometric mean geometric mean ratio group groups had no healthy control healthy individuals heterologous vaccine homologous IBD Immunosuppressed immunosuppressed patient immunosuppressive Immunosuppressive treatment Infection Inflammatory bowel disease jak inhibitors multicentre multivariable nine no significant difference Older Older age participant Patient patients treated Pfizer Primary outcome receiving Receptor binding domain recipient recruited reduced regimen response S1 RBD SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination significantly significantly lower Support T-cell Response T-cell responses the healthy therapy Tofacitinib Treatment ulcerative colitis Vaccine vaccine dose vaccine doses vaccine-induced antibody response VIP were measured [DOI] 10.1016/S2468-1253(22)00274-6 PMC 바로가기
Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection With Risk of Post-COVID-19 ConditionsArticle Published on 2022-11-012022-11-16 Journal: JAMA Psychiatry [Category] SARS, 유전자 메커니즘, [키워드] 95% CI adjusted age Anxiety baseline characterized Comorbidities condition COVID COVID-19 COVID-19 symptom COVID-19-related symptom Depression determine distress female Final Follow-up Future Health health care workers highest impairment increased risk individual Infection loneliness long-lasting lowest mechanism Nurse outcome pandemic participant Participants Perceived Perceived stress positive Postinfection prospective cohort study Psychological distress questionnaire Questionnaires reported returned risk risk factor SARS-COV-2 infection SARS-CoV-2 test sociodemographic factors Symptoms the mean these symptom used data were measured Worry [DOI] 10.1001/jamapsychiatry.2022.2640 PMC 바로가기