Fast Prediction of Binding Affinities of SARS-CoV-2 Spike Protein and Its Mutants with Antibodies through Intermolecular Interaction Modeling-Based Machine Learning분자간 상호작용 모델링 기반 기계 학습을 통한 SARS-CoV-2 스파이크 단백질 및 항체와의 돌연변이체의 결합 친화도의 빠른 예측Article Published on 2022-07-212022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] addition affinity antibodies antibodies binding antibody resistance Antibody therapeutics antigens approach artificial intelligence base binding binding affinities binding affinity COVID-19 Cryo-electron microscopy develop Effect help Interaction intermolecular interaction intermolecular interactions machine learning machine learning model machine learning models methodology modeling monoclonal antibodies monoclonal antibody mutant Mutation novel SARS-CoV-2 virus overcome pandemic predict prediction produced Receptor binding domain reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 virus spike Spike protein Structure the binding affinity the spike protein the vaccine variant variants of concern was used wild-type wild-type virus X-ray crystallography [DOI] 10.1021/acs.jpcb.2c02123 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening고처리량 항바이러스 스크리닝을 위한 SARS-CoV-2 허용 교모세포종 세포주Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 Administered Antiviral Antiviral screen cathepsin cathepsin B cathepsin L Cell cell line cell lysis cell monolayer cells cellular cellular infection system circulation Complete contagious CPE Cytopathic effect destruction develop effective evidenced expressed expressing fused Glioblastoma implementation infection with SARS-CoV-2 Nirmatrelvir omicron Permissive preclinical study productive viral replication reduction Remdesivir replicate reported required robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spread tested TMPRSS2 U87 cell line. Vaccine variant virus wild-type virus [DOI] 10.1016/j.antiviral.2022.105342 PMC 바로가기 [Article Type] Article
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article
Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?스파이크 단백질의 전하 분포 변화로 인한 낮은 TLR(Toll-like Receptor) 및 NF-κB 활성화가 오미크론의 낮은 병원성 원인이 될 수 있습니까?Review Published on 2022-05-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] Activation airway B.1.1.529 cellular changed charge cleavage clinics COVID-19 cytokine Cytokine storm Deletion deletions delta variant distribution Efficacy favor furin furin cleavage site FURIN expression Hypothesis immune immune cells immunization Innate immune cells Lower Lungs monoclonal antibody Multiple Mutation N-terminal domain Neutralizing antibodies neutralizing antibody NF-kappaB NF-κB NF-κB activation NTD omicron Omicron variant organs other variants pathogenicity predicted RBD reason for receptor Receptor binding domain replacing Replication resulting S1/S2 S1/S2 furin cleavage site SARS-CoV-2 significantly lower Spike protein spike protein. Substitution syncytium formation the Spike the spike protein therapeutic TLR TLRs TMPRSS2 Toll-like receptor Toll-like receptor (TLR) Toll-like receptors upper airway variant viral replication wild-type virus [DOI] 10.3390/ijms23115966 PMC 바로가기 [Article Type] Review
Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 TherapySARS-CoV-2에서 돌연변이를 유발하는 원동력 이해: 돌연변이 에너지와 COVID-19 치료에서 아르기닌 차단제의 역할Article Published on 2022-05-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 3CLpro accelerated ACE2 ACE2 protein Alpha Amino acid amino acids angiotensin Angiotensin receptor blockers angiotensin type1 receptor Angiotensin-converting enzyme anionic antiviral drug arginine assist association Beta binding biphenyl bisartans blocker blockers candidate drug cleavage site cleavage sites complex complexes Computational approaches conformation conformational contribute COVID-19 COVID-19 therapy Critical Delta delta variant driving drug energetics ENhance equilibrium Evolution of SARS-CoV-2 force furin furin cleavage site Gamma human clinical trials human population hydrolysis hydropathy hydrophilic hydrophobic interaction in silico Infection Interaction interactions interface investigated Lambda molecular Molecular biology molecular dynamic simulations molecular dynamics mutant mutants mutate Mutation omicron Omicron variants pharmacophores polar Protein RBD RBD binding RBD-ACE2 receptor Receptor-binding domain referred to replacement Replication Research residue residues role S-protein salt salt bridges SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 virus Sartans. Spread suggested target targets tetrazole the RBD the receptor-binding domain the SARS-CoV-2 virus Therapies translation Treatment treatment of COVID-19 Trigger understanding variant variants viral infection virus wild-type virus π-π interaction [DOI] 10.3390/v14051029 PMC 바로가기 [Article Type] Article
Face masking and COVID-19: potential effects of variolation on transmission dynamics안면 마스크와 COVID-19: 변이가 전파 역학에 미치는 잠재적 영향Article Published on 2022-05-012022-09-11 Journal: Journal of the Royal Society Interface [Category] COVID19(2023년), SARS, 변종, [키워드] acquired immunity attack rate basic reproduction number cause COVID-19 Delta Differential equations dose Effect Effectiveness Epidemic epidemiological estimate face Face mask Face masks growth growth rate healthcare Immunity individual induce Infection infections Infectious diseases infectious dose initial Live virus Mask masking Metrics omicron parameter Particles pre-vaccination Prevalence Prevent reduce reducing respiratory infections SARS-CoV-2 severe disease severe infections Side-effect SIR model smallpox suggested susceptible individual susceptible individuals Transmission Transmission dynamics transmission rate variants variolation variolation. wild-type virus [DOI] 10.1098/rsif.2021.0781 PMC 바로가기 [Article Type] Article
Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers의료 종사자의 COVID-19 예방 접종 6개월 후 항체 반응의 지속성 및 SARS-CoV-2 감염 빈도Article Published on 2022-04-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody BNT162b2 breakthrough infections coronavirus coronavirus disease COVID-19 decay defined Delta Evidence evidence of exhibiting healthcare healthcare worker Healthcare workers Month Neutralizing titer neutralizing titers nucleocapsid protein postvaccination respiratory respiratory infections response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 symptomatic tested United States vaccine-preventable diseases viruses wild-type virus worker zoonoses zoonoses. [DOI] 10.3201/eid2804.212037 PMC 바로가기 [Article Type] Article
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults Research Published on 2022-03-312022-10-05 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, 진단, [키워드] 95% confidence interval acute respiratory syndrome Adults Affect Asymptomatic asymptomatic infection average caused clinical care Clinical outcome coronavirus correlation Course develop diagnose dose Efficacy Evidence Future identify immune factor Immunity implication infected individual Infection inoculated intranasally Lateral flow test median Neutralizing antibodies non-randomized Open-label participant Participants Pathogenesis peaking per-protocol analysis Primary infection public health Quantitative quarantine rapid antigen test recommendation remained reported Result rising Safety safety analysis SARS-CoV-2 SARS-CoV-2 transmission Serious Adverse Events Seroconversion serum significantly higher spike-specific IgG Symptom Symptoms TCID50 Tolerability vaccination Variation Viable viral kinetics Viral load virus Volunteer were excluded wild-type virus [DOI] 10.1038/s41591-022-01780-9 [Article Type] Research
Generalized Methodology for the Quick Prediction of Variant SARS-CoV-2 Spike Protein Binding Affinities with Human Angiotensin-Converting Enzyme II변종 SARS-CoV-2 스파이크 단백질 결합 친화도와 인간 안지오텐신 전환 효소 II의 빠른 예측을 위한 일반화된 방법론Article Published on 2022-03-312022-09-11 Journal: The journal of physical chemistry. B [Category] SARS, 변종, [키워드] ACE2 ACE2 protein affinity angiotensin B.1.1.529 binding binding affinity can be used Complexes Generalized Human human Angiotensin-converting enzyme infections methodology omicron Omicron variant pandemic predict predicted prediction SARS-CoV-2 SARS-CoV-2 virus spike Spike protein surface area the binding affinity the SARS-CoV-2 virus the spike protein variant variant spike variants wild-type wild-type virus [DOI] 10.1021/acs.jpcb.1c10718 PMC 바로가기 [Article Type] Article
Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19COVID-19 환자의 림프구 하위 집합 및 사이토카인 프로필의 특성Article Published on 2022-03-282022-09-11 Journal: Virology Journal [Category] 변종, 치료기술, [키워드] Abnormalities age Analysis analyzed AUC B cells Care CD19 CD3 CD4 CD8 Cell Chongqing clinical Clinical and laboratory data coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical cutoff value cytokine cytokine profile Cytokines diabetes Diabetes Mellitus enrolled evaluate Factor Hospital admission ICU ICU admission ICU patient ICU Patients IL-6 independent predictor independent predictors Infection interleukin laboratory data Logistic regression Logistic regression analysis lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocyte subsets. Lymphocytes lymphopenia Most patients multivariate multivariate logistic regression analysis mutant natural killer no statistical difference No statistical differences non-ICU non-ICU patient non-ICU patients Odds ratio Patient patients patients with COVID-19 peripheral lymphocyte Predictive Predictive value receiver operating characteristic ROC ROC Curve selected sensitivity severe disease severe group severity severity of COVID-19 significantly significantly higher specificity statistical differences subset T cell T cells tested the disease Three Gorge Three Gorges treated university virus infection was used wild-type virus [DOI] 10.1186/s12985-022-01786-2 PMC 바로가기 [Article Type] Article