Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety. SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II): a national cohort study with nested test-negative design스코틀랜드의 증후성 질환에 대한 백신 부스터의 우려 및 효과에 대한 오미크론 변이의 심각도(EAVE II): 중첩 테스트 음성 디자인을 사용한 국가 코호트 연구Article Published on 2022-07-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted Admission booster booster dose Booster vaccine booster vaccines Care case-control study cohort analysis cohort study core COVID-19 defined Delta VOC dose dose of vaccination Edinburgh effective Effectiveness enhanced estimate Health Data Research UK Hospital admission hospitalisation individual individuals Infection initial Innovation laboratory data National offer omicron Omicron variant outcome platform positive positive RT-PCR proportion Public reduction in Reinfection risk risk of COVID-19 S-gene SARS-COV-2 infection Scottish severity Spread symptomatic symptomatic COVID-19 symptomatic disease symptomatic infection symptomatic SARS-CoV-2 infection tested the SARS-CoV-2 university vaccination Vaccine vaccine dose VoC with infection [DOI] 10.1016/S1473-3099(22)00141-4 PMC 바로가기 [Article Type] Article
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination감염 또는 예방 접종 후 재태 연령이 일치하는 모자에서 SARS-CoV-2 변이체에 대한 중화 항체 활성Article Published on 2022-06-222022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adaptive immunity age analyzed antibody COVID-19 Delta disease during pregnancy effective elicit first trimester gestation gestational age immune response immune responses immunoglobulins individuals Infection Infectious disease Infectious disease. less mother mRNA vaccine mRNA vaccines NAb NAbs neutralization neutralization activity Neutralizing plasma plasma sample Pregnancy pregnant Protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 variant second trimester sequence Spike protein spike variants time of delivery transfer unique vaccination Vaccine variant virion was measured with infection women WT spike [DOI] 10.1172/jci.insight.157354 PMC 바로가기 [Article Type] Article
The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China중국 난징에서 Delta 변이형 감염 고령 환자에서 불활성화 백신의 역할Article Published on 2022-05-182022-09-11 Journal: Aging (Albany NY) [Category] COVID19(2023년), SARS, 변종, [키워드] Acute kidney injury acute respiratory distress acute respiratory distress syndrome ARDS BBIBP-CorV cardiac injury China Clinical severity co-morbidities CoronaVac coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines Delta delta variant demographic data dose dose of vaccination effective enrolled evaluated group Hospital stay IMPROVE inactivated Inactivated vaccine Inactivated Vaccines incidence Infection Injury Laboratory parameters less MODS morbidities multiple organ dysfunction multiple organ dysfunction syndrome Nanjing Older older patient older patients organ dysfunction organ dysfunction syndrome organ dysfunction. pandemic Patient respiratory distress Septic shock syndrome three group three groups vaccination Vaccination Status were recorded with infection [DOI] 10.18632/aging.204085 PMC 바로가기 [Article Type] Article
An assessment of the vaccination of school-aged children in England against SARS-CoV-2SARS-CoV-2에 대한 영국의 취학 연령 아동 예방 접종 평가Article Published on 2022-05-182022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] adverse event adverse events age Analysis assumed average benefit childhood children Cohort COVID-19 death deaths delta variant Efficacy England Evidence expansion facilitate generate greater group Health hospital Hospital admission Hospital admissions immunisation individual Infection infection. interactions involved knowledge less lower risk mathematical mathematical model Measures projection public health reduced reduction reduction in Relaxation reported resource SARS-CoV-2 Spread substantial reduction substantial reductions suggested the vaccine vaccination Vaccine vaccine administration vaccine efficacy with infection [DOI] 10.1186/s12916-022-02379-0 PMC 바로가기 [Article Type] Article
Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar카타르에서 SARS-CoV-2 오미크론 감염에 대한 mRNA 백신 부스터의 효과Article Published on 2022-05-122022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association B.1.1.529 B.1.617.2 BNT162b2 booster booster dose booster doses booster vaccination Cohort cohorts conducted coronavirus coronavirus disease Coronavirus disease 2019 cumulative cumulative incidence death dose Effect effective Effectiveness effort Follow-up Hospitalization incidence Infection less Messenger RNA Moderna mRNA mRNA-1273 mRNA-1273 vaccine of BNT162b2 omicron Pfizer-BioNTech protection regression models retrospective cohort study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus symptomatic symptomatic infection symptomatic SARS-CoV-2 infection Vaccine variant variants with infection [DOI] 10.1056/NEJMoa2200797 PMC 바로가기 [Article Type] Article
Follow-up of patients with COVID-19 by the Delta variant after hospital discharge in Guangzhou, Guandong, China중국 광둥성 광저우에서 퇴원한 후 델타 변종에 의한 COVID-19 환자 추적 관찰Article Published on 2022-05-062022-09-11 Journal: Revista do Instituto de Medicina Tropical de São [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Antibody detection asked Asymptomatic average B.1.617.2 Chain Reaction China community transmission Complete Computed tomography conducted contributed coronavirus COVID-19 case COVID-19 cases cycle threshold Delta delta variant diagnosis of COVID-19 discharge discharged patient discharged patients exhibited Follow-up globe Guangdong Guangzhou had no Hair loss Health health examination hospital discharge Infection Laboratory laboratory diagnosis life mass vaccination Mental nucleic acid Nucleic acid detection nucleic acid testing Patient patients with COVID-19 physical polymerase chain polymerase chain reaction positive positive result proportion pulmonary computed tomography Quality of life ranged recurrence risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 patient SARS-CoV-2 patients sense severe acute respiratory syndrome Coronavirus significantly subject Symptom undergo vaccination variant with infection [DOI] 10.1590/S1678-9946202264031 PMC 바로가기 [Article Type] Article
Incidence of SARS-CoV-2 infection among COVID-19 vaccinated and unvaccinated healthcare personnel, first responders, and other essential and frontline workers: Eight US locations, January-September 2021COVID-19 예방 접종 및 예방 접종을 받지 않은 의료 인력, 최초 대응자, 기타 필수 및 최전선 작업자 사이의 SARS-CoV-2 감염 발생: 2021년 1월-9월 미국 8개 지역Article Published on 2022-05-012022-09-11 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval added analyzed association average baseline benefit changes in Cohort Community COVID-19 COVID-19 vaccination COVID-19 vaccine declining delta variant demographics Effectiveness essential worker estimate evaluate exposure to healthcare personnel high risk higher risk incidence incidence of COVID-19 Infection infection risk laboratory-confirmed laboratory-confirmed SARS-CoV-2 infection lower risk nasal swab participant physical distancing Protective remained reported symptoms responders SARS-CoV-2 SARS-COV-2 infection significantly Vaccine vaccine. with infection [DOI] 10.1111/irv.12956 PMC 바로가기 [Article Type] Article
Study of the epidemiology of COVID-19 in Ontario elementary and secondary school education workers: an interim analysis following the first school year온타리오주 초·중등학교 교육 종사자를 대상으로 한 코로나19 역학 연구: 첫 학년도 이후 중간 분석Article Published on 2022-04-012022-09-11 Journal: Canadian Journal of Public Health = Revue Canadien [Category] COVID19(2023년), SARS, 치료법, [키워드] 95% confidence interval adjusted Canada Child Cohort COVID-19 dose Dried blood spots education English Epidemiology Étude exposure to Factor Factors female French help household incidence incidence rate Infection information interim analysis measure multivariable Multivariable regression Multivariable regression analysis nucleocapsid pandemic participant Participants Positive test prospective cohort study Protective questionnaire rate ratio Receptor binding domain reduce regression analysis reported RéSUMé risk factor Risk factors Risk factors. risk of infection SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine serologic testing specimen SRAS-CoV-2 submitted TEMPS tested Travel vaccination Vaccinations virus was used were assessed with infection [DOI] 10.17269/s41997-022-00613-z PMC 바로가기 [Article Type] Article
First nosocomial cluster of COVID-19 due to the Delta variant in a major acute care hospital in Singapore: investigations and outbreak response싱가포르 주요 급성 치료 병원의 델타 변종으로 인한 COVID-19의 첫 번째 병원 클러스터: 조사 및 발병 대응Article Published on 2022-04-012022-09-11 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjusted odds ratio affected Analysis Breakthrough infection Care Case isolation changes in Cluster Cohort Contact Contact tracing coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 vaccines delta variant described Effectiveness enhancement evaluated examined Factor hospital household contacts IMPROVE Infection infection control Inpatient Inpatients investigated measure Measures mRNA1273 nine nosocomial occurred odds of infection outbreak Patient patients patients with COVID-19 Personal protective equipment Phylogenetic analysis Phylogeny phylogeny. positive quarantine quarantine measures SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Singapore Surveillance Swab swabs tested vaccination vaccine breakthrough infections Ventilation ward was performed with COVID-19 with infection [DOI] 10.1016/j.jhin.2021.12.011 PMC 바로가기 [Article Type] Article