PaO – Page 20 – Communicable Diseases Research

Use of Venovenous Extracorporeal Membrane Oxygenation in Critically-Ill Patients With COVID-19

Medicine

Published on 2020-12-102022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial

성인의 중증 COVID-19 치료를 위한 분무형 계면활성제(COV-Surf): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Randomized Controlled Trial

Published on 2020-12-102022-09-10
Journal: Trials [Category] MERS, SARS, 비임상, 임상,

[키워드] 1080 24 hour 24 hours 48 hour 48 hours ACE2 ADEs administration Adverse adverse event adverse events AEs ALEA All participant All participants allergy alveolar angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anticipated attending physician bind Blinding block randomization Blood bovine breath buffer calcium cells cellular cholesterol Chronic kidney disease class clinical Clinical improvement clinical trial clinical trials Cohort Combination comparator Compliance Concentration conducted Consent contraindication contributing to Control control arm controls COVID-19 COVID-19 adult patient COVID-19 patients current cytokine Data collection Data monitoring committee death declined defined delivery described Device dialysis discretion dissemination dose drug Effect Efficacy EGFR element Eligible participants end point End-Expiratory Pressure Endotracheal intubation enrolled Enrollment enrolment epithelial Escalation EudraCT evaluate exclusion exclusion criteria expected fatty Fatty acid feasibility free fatty acid Frequency hospital hospitalised hypoxia impair include inclusion criteria index Inflammatory marker inflammatory markers Inflammatory response intensive care intensive care unit Intervention investigator Kidney disease lack liver liver failure Local lung lung lavage mechanical ventilation mechanical ventilator mechanically ventilated patient mechanically ventilated patients mixture Mortality nebulisation number objective Open-label opinion Ordinal Scale other treatment outcome oxidative stress Oxygenation PaO participant Patient PCR PEEP Phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol phosphatidylinositol phospholipid PIP Placebo plasma Pneumothorax Positive end-expiratory pressure Prevent Primary outcome progression Protein protocol pulmonary compliance pulmonary hemorrhage pulmonary ventilation quantification randomisation randomised randomised controlled trial Randomized Randomized controlled trial reached receive recorded recruitment reduction Registered reported Respiratory failure SAEs Sample size SARS-CoV-2 viral load SARS-CoV-2 virus secondary outcome Secondary outcomes Serious Adverse Events severe COVID-19 severity sphingomyelin Stage Standard Standard of care status Study protocol subject supplementary material surface tension surfactant synthesis tension the WHO tissue damage total sample size tracheal tracheal aspirate Tracheal aspirates transfer Treatment Trial Trial Steering Committee turnover unique university University College London usual standard of care Ventilation Ventilation Index ventilatory support VFD vibrating mesh nebulizer Viral Viral load virus water website weight with COVID-19 worsening
[DOI] 10.1186/s13063-020-04944-5 PMC 바로가기 [Article Type] Randomized Controlled Trial

Chest CT imaging features of COVID-19 and its correlation with the PaO 2 /FiO 2 ratio: a multicenter study in Upper Egypt

Research

Published on 2020-12-082022-10-31
Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19,

Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19

중등도 또는 중증 코로나19 환자에서 조기 코르티코스테로이드 치료 후 바이러스 제거

Article

Published on 2020-12-042022-09-01
Journal: Scientific Reports [Category] MERS, 진단, 치료법, 치료제,

Patterns of Deterioration in Moderate Patients With COVID-19 From Jan 2020 to Mar 2020: A Multi-Center, Retrospective Cohort Study in China

Medicine

Published on 2020-12-032022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Acute heart failure Acute kidney injury acute respiratory distress addition AKI ARDS article Blood Characteristics characterized China clinical status Coagulopathy collected contribute coronavirus disease COVID-19 Critical critical condition Deterioration develop disease deterioration dysfunction feature globe group Guangdong hepatic injury hypoxia IQR Laboratory lactic acid manifestation median time moderate Moderate COVID-19 Mortality multicenter multiple organ dysfunction occurred Older organ damage organ injury over PaO Patient patients patients hospitalized pattern proportion respiratory respiratory rate retrospective cohort study Severe case Shock syndrome therapeutic time point
[DOI] 10.3389/fmed.2020.567296 PMC 바로가기 [Article Type] Medicine

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol

SARS-CoV-2(COVID-19) 양성 중환자에서 보조 요법으로 고용량 아연 정맥 주사에 대한 무작위 대조 시험: 시험 프로토콜

Article

Published on 2020-12-022022-09-11
Journal: BMJ Open [Category] SARS, 임상,

[키워드] Analysis caused Controlled trial coronavirus COVID-19 Critically ill demonstrated discharge distress double-blind duration of follow-up Effect Elemental end-organ Ethical approval Ethics ethics committee evaluate healthcare High-dose hospitalised patient Human hypoxic independent Infectious diseases Injury International intravenous lowest oxygen saturation mechanism non-ventilated patient non-ventilated patients oxygen oxygen saturation oxygen saturations oxygen supplementation Oxygenation pandemic PaO participant peer-reviewed Placebo positive primary outcome measure Primary outcome measures protective effect public health randomised controlled trial recruited recruitment reduction registration number Research Ethics respiratory respiratory distress Respiratory distress syndrome Respiratory illness respiratory infections Result resulting RNA polymerase robust SARS-CoV-2 SARS-COV-2 infection syndrome therapy Treatment trial protocol Vaccine ventilated patient ventilated patients Viral viral respiratory infection viral respiratory infections Virology was obtained Zinc
[DOI] 10.1136/bmjopen-2020-040580 PMC 바로가기 [Article Type] Article

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

Observational Study

Published on 2020-12-012022-10-04
Journal: The Lancet. Respiratory Medicine [Category] Coronavirus, Fulltext, MERS, 임상,

[키워드] acute respiratory distress analysed ARDS baseline calculate cause Classifier Cohort collected Concentration COVID-19 COVID-19-associated ARDS Critically ill patient Cutoff demographic described died eight Exploratory analysis FIVE Health Hyperinflammatory identify IL-6 inflammatory pathway inspired air intensive care units interleukin-6 IQR laboratory data median Mortality multicentre multiorgan failure Necrosis Older oxygen PaO Patient patients patients with ARDS phenotype Phenotypes point-of-care Prevalence Probability proportion prospective observational study randomised controlled trial receptor recruited severity significantly lower Survivors syndrome systemic inflammation TNFR1 unlikely upregulation was used
[DOI] 10.1016/S2213-2600(20)30366-0 PMC 바로가기 [Article Type] Observational Study

Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients

중환자 코로나19 환자의 정맥 혈전색전증 예측을 위한 바이오마커

Article

Published on 2020-12-012022-09-11
Journal: Thrombosis research [Category] MERS, SARS, 바이오마커,

[키워드] activated activated partial thromboplastin time an area Analysis Antithrombin AUC Biomarker C-reactive protein characteristic clinician Combination Computed tomography computed tomography scan Confirmed COVID-19 infection coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients Critical illness Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients CRP D-dimer develop diagnosed Diagnosis dimer early diagnosis End Expiratory Pressure fibrinogen hospital Hypoxemia intensive care intensive care unit International international normalized ratio Linear regression Mortality Multivariate analysis Negative predictive value normalized PaO partial thromboplastin time Patient Platelet Platelet count Positive End Expiratory Pressure Positive predictive value predicted Predictive Predictive value pressure Probability receiver operating characteristic retrospective cohort study risk ROC ROC Curve the timing Thromboembolism THROMBOPLASTIN Treatment Ultrasound variable Venous Thromboembolism VTE was done were used
[DOI] 10.1016/j.thromres.2020.09.017 PMC 바로가기 [Article Type] Article

Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic

Observational Study

Published on 2020-12-012022-10-05
Journal: Medicina intensiva [Category] SARS, 임상,

[키워드] Admission age APACHE II arterial assisted ventilation Automatic Bacterial Care carried Characteristics Cohort Comorbidities complications COVID-19 Deceased Demographic variables experience Fisher exact test Frequency General population HFO high-flow oxygen therapy hospital hypertension IMV incidence Infection initial Insuficiencia respiratoria Invasive mechanical ventilation laboratory data lack males Mann-Whitney Mechanical mechanical ventilation medians obesity Oxygen therapy Oxygenation pandemic PaO parameters Patient patients patients with COVID-19 Pneumonia Prognostic marker required respiratory Respiratory failure severity single-center SOFA survivor the patient the SARS-CoV-2 turn variables Ventilación mecánica Ventilation was used Wilcoxon test with COVID-19
[DOI] 10.1016/j.medin.2020.05.018 PMC 바로가기 [Article Type] Observational Study

The effect of tocilizumab on cytokine release syndrome in COVID-19 patients

COVID-19 환자의 사이토카인 방출 증후군에 대한 토실리주맙의 효과

Article

Published on 2020-12-012022-09-12
Journal: Pharmacological Reports [Category] MERS, SARS, 진단,

[키워드] 30-day mortality rate administration analysed ARDS C-reactive protein (CRP caused clinical evolution clinical history conducted COVID-19 patient Cytokine release syndrome D-dimer level decrease demographic dose Efficacy and safety Evidence Evolution Factor Fever first dose hospitalised patient hypertension ICU admission IL-6 increase in initial lymphocytopenia Mild moderate Mortality PaO parameter Patient PCR polymerase chain positive Predictive radiologic reduction required respiratory retrospective SARS-CoV-2 severe ARDS Support TCZ the patient Tocilizumab Treatment variables ventilator was related
[DOI] 10.1007/s43440-020-00186-z PMC 바로가기 [Article Type] Article