Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the “endemic Burkitt Lymphoma belt”"풍토병 Burkitt 림프종 벨트"의 사하라 사막 이남 인구에서 유전자 흐름과 말라리아에 의한 자연 선택의 유전 적 특징Research Article Published on 2019-03-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Affect African Analysis association ATP2B4 baseline Burkitt lymphoma calcium Cancer characterization characterized chronic infection coding complex confluence determine disease East Effect Endemic erythrocytes event Evidence evidence of expressed facilitate gene flow Genetic genomic genomic data genotyped Great Lake Great Lakes group groups highest Hypothesis incidence individual intensity malaria Migration mixture natural natural selection North occurred Occurrence opposite pediatric Population populations Positive selection predominant SNP sub-Saharan Africa Support Transmission Uganda West [DOI] 10.1371/journal.pgen.1008027 PMC 바로가기 [Article Type] Research Article
A metagenomic viral discovery approach identifies potential zoonotic and novel mammalian viruses in Neoromicia bats within South AfricaResearch Article Published on 2018-03-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Adenoviridae Adenovirus African Amplicon sequencing Analysis anthropogenic approach bat bats Circoviridae coding collected Complete conserved Contact Conventional Coronaviridae coronavirus Coronaviruses Coverage determine eight fecal FIVE gene region generate genetic diversity Genome Herpesviridae highlighting Host hosts identify identity Illumina Miseq intestinal tissue lack library mammalian metagenomic metagenomic sequencing Middle East MiSeq nucleotide Papillomaviridae Parvoviridae PCR analysis PCR assay platform Population producing rectal Region regions Sample sequence sequenced sequencing data sequencing depth South Africa Specy Structure syndrome viral family Viral particles virus was determined were used widespread zoonotic [DOI] 10.1371/journal.pone.0194527 PMC 바로가기 [Article Type] Research Article
A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombinationResearch Published on 2017-06-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Accessory genes avian coronavirus cause Cell cell lines cells Characteristics chicken chimeric co-transfected coding Complete coronavirus ectodomain Embryonated eggs generate genetics Genome genomic growth IBV in vivo infect Infectious Bronchitis Virus isolates Major marker MHV Modification Molecular biology mouse hepatitis virus murine mutations parental poultry recombinant Recombination replaced respiratory pathogen Result Reverse genetics system RNA RNA recombination specific mutation spike gene spike glycoprotein strain Strains supplementary material synonymous Targeted RNA recombination Vaccine Vaccine development virulent virus was performed was used wild-type [DOI] 10.1186/s12985-017-0775-8 PMC 바로가기 [Article Type] Research
Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa차세대 "-omics" 접근 방식으로 녹농균(Pseudomonas aeruginosa)의 박테리오파지 감염 동안 숙주 RNA 대사의 대규모 변경이 밝혀짐Research Article Published on 2016-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Analysis approaches Bacteria Bacterial bacterial strains bacteriophage bacteriophages block changes in characterized coding Complete Course Degradation demonstrated drastic early stage Escherichia coli expressed family Gene Expression generate highlight Host infecting Infection infection cycle infection cycles Interaction interfere involved knowledge lifecycle massive metabolic pathway metabolic pathways metabolism metabolomics molecular molecular mechanism molecular mechanisms multidrug resistant nucleotide opportunistic pathogen pathogen produced promote proportion Pseudomonas aeruginosa pyrimidine Regulation required RNA RNA-sequencing RNAs shown stimulate strain suggested therapeutic therapeutic potential therapy transcript transcriptomics treat Trigger triggers Viral viral replication Viral RNA viral RNAs virulent virulent phage virus viruses [DOI] 10.1371/journal.pgen.1006134 PMC 바로가기 [Article Type] Research Article
Genotyping coronaviruses associated with feline infectious peritonitisStandard Published on 2015-06-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] Amino acid Asymptomatic coding Complete coronavirus death Deletion develop disease Endemic Genome genome sequence healthy Infection majority Mild Mutation ORF Pathogenesis previous study Protein S protein S2 domain Support Surface glycoprotein tissue virus [DOI] 10.1099/vir.0.000084 PMC 바로가기 [Article Type] Standard
Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex알파인 아이벡스의 주요 조직 적합성 복합체에서 국내 염소 생성 변이로부터의 이입Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive allele alleles Alpine ibex balancing selection breed carried chromosomal region Clustering coding coding regions Defense Evidence functional gene genetic diversity Genetic polymorphism genetic variability Genetic variation genomes goat Haplotype haplotypes heterozygosity histocompatibility histocompatibility complex homozygous Ibex identify immune system individual introgression investigated involved loci locus Major major histocompatibility complex mechanism MHC non-coding region pathogen Pathogens polymorphism populations provide Research restored sequence sequenced Sequencing signature SNP SNP allele SNP alleles species Support susceptible thought two allele Two alleles Variation [DOI] 10.1371/journal.pgen.1004438 PMC 바로가기 [Article Type] Research Article
A Novel Highly Divergent Protein Family Identified from a Viviparous Insect by RNA-seq Analysis: A Potential Target for Tsetse Fly-Specific AbortifacientsRNA-seq 분석을 통해 태생 곤충에서 식별된 매우 다양한 새로운 단백질 패밀리: 체체 파리 관련 낙태 환자의 잠재적 표적Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abortifacient addition African Amino acid amino acid sequence Analysis approaches casein cattle causative agents characterization coding control mechanisms Critical Differential analysis enrichment Factor family fecundity female functional genes encoding Genome genomic homeostasis Human Identified identify indicate insect Interference knockdown lactating lactation lipid metabolism maintenance mammalian mechanism mechanisms metabolism mother s milk novel occur organized Potential progeny Protein protein level protein synthesis Proteins proteome provided reduce reduced reducing Region reproductive resource RNA-Seq RNA-seq data secretion sequence similarity Seven shown similarities sleeping sickness specificity suppression synthesis target to define transcript Transcriptome transcripts Transferrin tsetse tsetse flies tsetse fly unique variant Viviparous were expressed while [DOI] 10.1371/journal.pgen.1003874 PMC 바로가기 [Article Type] Research Article
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence AttenuationCryptococcus neoformans var.의 게놈 및 전사체 분석 grubii, 복잡한 RNA 발현 및 독성 약화로 이어지는 소진화를 밝혀냄Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition alternative polyadenylation Analysis analyzed annotation attenuation automated C. neoforman CDS chromosomal coding coding DNA sequence coding DNA sequences Comparative analysis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans death Efficiency examination expressed gene expressed genes feature fungi Gene Expression Genes Genetic genetics Genome genome sequence genomic studies genomic study human pathogen identify Immunocompromised Immunocompromised patients in vitro culturing indicate intron introns involved isolate isolates Laboratory leading manual curation meningoencephalitis microevolution microevolutionary miscRNA miscRNAs molecular motif Mutation Non-coding RNAs occur opportunistic pathogen pathogen pathogenic performed phenotypic phenotypic and genome re-sequencing analysis polyadenylation site polyadenylation sites provide Region Regulation Replication representing responses responsible resulting RNA RNA-Seq-based analysis sequence sequenced sequences Sequencing serotype Spectrum strain Stress stress responses Transcription Transcriptome untranslated regions UTRs VAR variant variety virulence yeast [DOI] 10.1371/journal.pgen.1004261 PMC 바로가기 [Article Type] Research Article
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while [DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence주요 대립 유전자 참조 서열을 사용한 가족 4중주에서의 단계적 전체 게놈 유전적 위험Research Article Published on 2011-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele Analysis approach Author base pairs base pairs) Blood blood clot characterization coding compound heterozygosity contribute contributing to demonstrated develop disease disease risk disease-associated estimation facilitate family Gene genetic determinant genetic determinants genetic information genetic profile genetic risk genetic risk factor genetic risk factors Genetic variation Genome genomes Genotype Haplotype Human human leukocyte antigen identify Interpretation leukocyte loci lowest lung Major median medications methodology nuclear nuclear family occur pharmacological predisposition Pulmonary embolism quantification Quartet Recombination reference reference sequence risk Risk assessment risk for disease sequence Sequencing sequencing error sequencing errors therapy Thrombophilia variant whole-genome sequencing [DOI] 10.1371/journal.pgen.1002280 PMC 바로가기 [Article Type] Research Article