A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic optionsArticle Published on 2022-09-012022-11-16 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] acetyl-CoA Activation alteration analyzed anti-inflammatory function CLYBL combating Control convert COVID-19 COVID-19 patients COVID-19 progression COVID-19 samples Critical Defense enzyme healthy controls Host host protein Human identify immune modulatory Immunity increase in Inflammation itaconate Macrophage metabolism metabolite moderate modulating observation pathway Pneumonia Protein proteome proteomes proteomic regulated RNA virus SARS-CoV-2 viruses severe symptom signaling pathway suggested TCA cycle the disease therapeutic option therapeutic target treating COVID-19 Urine worsening [DOI] 10.1007/s11427-021-2070-y PMC 바로가기
A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article
Stock market response to COVID-19 pandemic: A comparative evidence from two emerging marketsResearch article Published on 2022-09-012022-10-05 Journal: Scientific African [Category] 진단, [키워드] Botswana COVID-19 COVID-19 case COVID-19 pandemic Critical deaths Effect estimate Evidence Ghana greater help measure Non-parametric pandemic Parametric provide reported robust Shock stock Stock market Support [DOI] 10.1016/j.sciaf.2022.e01300 [Article Type] Research article
SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesisSARS-CoV-2 감염 유발 성장 인자는 COVID-19 발병 기전에서 다른 역할을 합니다Article Published on 2022-09-012022-09-11 Journal: Life sciences [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] adverse effect adverse effects angiopoietin association COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Critically ill cytokine Cytokine storm Cytokine storms Cytokines D-dimer disease dysregulation EGF elevated Endothelial dysfunction EPO erythropoietin exhibited G-CSF growth factor Growth factors HGF Hospitalized ICU Inflammation Injury inverse correlation investigation marker moderate Myoglobin negative correlation non-ICU occur P-selectin Pathogenesis pathogenesis of COVID-19 pathophysiology PDGF plasma positive correlation reflected remained repair SARS-COV-2 infection selectin specific disease Thromboembolism tissue tissue injury Tissue injury. upregulated vague VEGF was performed [DOI] 10.1016/j.lfs.2022.120703 PMC 바로가기 [Article Type] Article
Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients코로나19 환자에서 다양한 비타민과 미네랄의 분자 기전과 치료 효과Review Published on 2022-09-012022-09-11 Journal: Journal of trace elements in medicine and biology [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] activities addition Anti-inflammatory drugs antioxidant antioxidants Antiviral antiviral properties antiviral property boost component copper correlation COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness cytokine release Cytokines disease Effect Factor Health high mortality immune function immune functions immune system Increased Infectious disease Inflammation Inflammatory cytokine Inflammatory cytokines iron lack manganese mechanism metabolic processe metabolic processes Micronutrient micronutrients mineral Minerals modulate mortality rate mortality rates oxidative stress Prevalence rapidly spreading disease reason remedy respiratory distress SARS-CoV-2 Selenium severe COVID-19 Severe respiratory distress Support therapeutic effect Trace element trace elements Treatment Vitamin vitamin A vitamins Zinc [DOI] 10.1016/j.jtemb.2022.127044 PMC 바로가기 [Article Type] Review
A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Applied Microbiology and Biotechnology [Category] SARS, 치료제, [키워드] ACE-2 ACE-2 receptor Adsorption angiotensin-converting enzyme-2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral effect antivirals binding block caused Cell Cell culture cell entry coronavirus SARS-CoV-2 COVID-19 Critical death demonstrated develop displaying Effect event Flavanone-7-O-glucoside flavonoid HCoV 229E Hesperetin-7-rutinoside host cell impair impairing imperative in vitro induce interact Interaction interfere management mechanism mental health molecular docking analysis Nanoparticulate compound pandemic receptor Region SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein. spike glycoprotein Spread supportive care targeted therapy the SARS-CoV-2 viral infection virucidal [DOI] 10.1007/s00253-022-12112-9 PMC 바로가기
COVID-19 in spinal cord injury patients at a veterans administration hospital: A case seriesArticle Published on 2022-09-012022-11-16 Journal: The journal of spinal cord medicine [Category] SARS, 치료기술, [키워드] administration age AIS Asymptomatic BMI case sery Chronic kidney disease chronic obstructive clinical feature Clinical findings co-morbidities Comorbidity Complete Completeness Confirmed COVID-19 infection cough COVID-19 COVID-19 pandemic Critical diagnostic disease course elevated facilitate Fever FIVE General population hospital implementation individual Infection Inflammatory marker Injury Level male Mild Patient predictor Presence presenting severe SARS-CoV-2 severity shown single center spinal cord Spinal cord injury treated Treatment unit veteran viral spread with COVID-19 [DOI] 10.1080/10790268.2020.1871254 PMC 바로가기
Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서Review Published on 2022-09-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications Therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle [DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review
Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 RegistryObservational Study Published on 2022-09-012022-10-04 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), SARS, 임상, [키워드] acute COVID-19 adjusted association children cohort study Comorbidity coronavirus disease COVID-19 COVID-19 illness Critical Critical illness defined died entire cohort Gastrointestinal GI symptom hospital Hospitalized illness incidence Inflammatory International liver manifestation median age MIS-C Mortality multicenter Multivariable models occurred Older outcome Patient patients performed primary outcome measure registry respiratory retrospective review SARS-CoV-2 secondary Secondary outcomes subpopulation syndrome Universal [DOI] 10.1097/INF.0000000000003589 PMC 바로가기 [Article Type] Observational Study
Virtual screening of substances used in the treatment of SARS-CoV-2 infection and analysis of compounds with known action on structurally similar proteins from other virusesArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료제, [키워드] added Analysis anti-SARS-CoV-2 applied bibliometric analysis Biomedical research caused Compound COVID-19 pandemic Critical docking drug drugs effective effective drug etiological agent in silico in-silico inhibitors less management molecular docking new virus pandemic potential therapy Prevent Protein Proteins provided reduce researcher resource respiratory SARS-CoV-2 SARS-COV-2 infection shown the disease therapeutic compound Topic Transmissibility Treatment Treatment of SARS-CoV-2 infection Virtual screening virus viruses [DOI] 10.1016/j.biopha.2022.113432 PMC 바로가기