Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19COVID-19 소아 환자 치료를 위한 용량 선택을 지원하기 위한 렘데시비르 및 그 대사물의 생리학적 기반 약동학 모델링Article Published on 2021-04-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 치료제, [키워드] Administered applied children clinical study compassionate use coronavirus disease Coronavirus disease 2019 COVID-19 Day described disease dosage Dosing Emergency use authorization healthy volunteer healthy volunteers indicated Inflammatory information initiated intravenous Loading dose maintain maintenance dose metabolite metabolites Model modeling pandemic pediatric Pediatric patient Pediatric patients pharmacokinetic Phase I Population predict predicted regimen Remdesivir reported Selection severe coronavirus disease Simulation Support supported syndrome therapeutic Treatment [DOI] 10.1002/cpt.2176 PMC 바로가기 [Article Type] Article
COVID-19 Pneumonia on Post-Operative Day 2 after Esophagectomy: Performing Esophago-Gastric Junction Cancer Surgery during the SARS-Cov-2 Second WaveCase Report Published on 2021-03-272022-10-31 Journal: Current Oncology [Category] COVID-19, [키워드] acute respiratory syndrome Cancer Care Chest consequence coronavirus coronavirus disease COVID-19 COVID-19 pandemic curative Day diagnosed Effect esophagectomy finding gastro-esophageal junction cancer healthcare Hospital stay increased risk Intention junction Measures outcome pandemic Patient Performing Pneumonia reduce Respiratory function resulting risk second second wave surgery surgical the patient Transmission Treatment Wave [DOI] 10.3390/curroncol28020128 PMC 바로가기 [Article Type] Case Report
Unravelling the Perspectives of Day and Night Traders in Selected Markets within a Sub-Saharan African City with a Malaria Knowledge, Attitude and Practice Survey말라리아 지식, 태도 및 실천 조사를 포함한 사하라 이남 아프리카 도시의 선택된 시장에서 낮과 밤 거래자의 관점을 풀어내기Article Published on 2021-03-262024-08-08 Journal: International Journal of Environmental Research and Public Health [Category] 말라리아, [키워드] Attitude Day knowledge malaria market Night Perspectives Practice traders [DOI] 10.3390/ijerph18073468 PMC 바로가기 [Article Type] Article
The role of teicoplanin in the treatment of SARS‐CoV‐2 infection: A retrospective study in critically ill COVID‐19 patients (Tei‐COVID study)Observational Study Published on 2021-03-262022-10-04 Journal: Journal of medical virology [Category] SARS, 임상, 치료제, [키워드] acute respiratory syndrome analysed Analysis Antibiotics Antiviral antiviral activity Biochemical parameters BSI C‐reactive protein causative pathogen Clinical stages Cohort complementary control group controls coronavirus coronavirus disease correlated Course COVID COVID‐19 COVID‐19 patient COVID‐19 Critically ill Critically ill patient critically ill patients Day effective empiric antibiotic enrolled evaluate expressed glycopeptide Hospitalization Hospitalized ICU ICUs infected patient intensive care unit kidney lack Liver function lymphocyte mechanical ventilation Mortality onset of disease outcome pathogenic mechanism Patient patients Pneumonia Primary outcome reduced reducing Research respiratory viral infection retrospective Retrospective study SARS‐CoV‐2 SARS‐CoV‐2 several limitation Side effect significantly Staphylococcus aureus statistical statistical significance statistically significant difference suggested sustained Teicoplanin the disease therapeutic therapy treat treated Treatment two group viral clearance viral damage viral replication virus White blood cell [DOI] 10.1002/jmv.26925 PMC 바로가기 [Article Type] Observational Study
Case study of a critically ill person with COVID-19 on ECMO successfully treated with leronlimabCase report Published on 2021-03-232022-10-30 Journal: Journal of Translational Autoimmunity [Category] COVID-19, [키워드] Administered Analysis approach approval baseline case study CCR5 chemokine Chemokine receptor Clinical improvement confirmed case Coronavirus disease 2019 Coronavirus-disease-2019-(COVID-19) country COVID-19 COVID-19 treatment Critical Critically ill Critically ill patient Day demonstrated Dexamethasone discharged disrupt dose dysregulated ECMO effective elevated evade Evidence extracorporeal membrane oxygenation Extracorporeal-membrane-oxygenation-(ECMO) first dose Hospitalization Host immune response IgG4 immune function immune response improvement infection with SARS-CoV-2 inflammatory cells intensive care Leronlimab Ligand male Mild-to-moderate monoclonal antibody morbidity and mortality Mortality NEWS2 pandemic participant Phase 3 Placebo placebo-controlled Randomized receiving receptor recruitment released reported SARS-CoV-2 SARS-CoV-2 vaccine score severe disease shown Standard of care subject subset survival treated Treatment treatment of HIV treatments for COVID-19 Trial triggered urgency vaccination Vaccines variant virus was reduced with COVID-19 [DOI] 10.1016/j.jtauto.2021.100097 PMC 바로가기 [Article Type] Case report
Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19Article Published on 2021-03-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adjuvant antibody average binding C-terminal domain candidate Containing COVID-19 COVID-19 infection Day distribution domain Efficacy elicit heptad repeat IC50 immunized immunodominant immunogen induced linear epitope mice monoclonal antibody Neutralization antibody Neutralizing antibodies Neutralizing titer potent Prevent Protein pseudo-virus RBD recombinant regions Safe spike Structure Support tested the RBD trimeric Vaccine vaccine candidate [DOI] 10.3390/vaccines9030296 PMC 바로가기 [Article Type] Article
Measuring Time-Varying Effective Reproduction Numbers for COVID-19 and Their Relationship with Movement Control Order in MalaysiaArticle Published on 2021-03-222022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] assumed average confirmed case Control COVID-19 Day Engineering epidemic curve Government Johns Hopkins University less Local Malaysia movement movement control order number peaked ranged relationship remained Repository reproduction Reproduction number SARS-CoV-2 virus Science spike Spread System the epidemic the mean Transmission used data [DOI] 10.3390/ijerph18063273 PMC 바로가기 [Article Type] Article
Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trialCOVID-19(FLARE) 외래 환자의 조기 항바이러스 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-03-082022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] 24 hours 48 hour 48 hours absence admitted to ICU aetiology age ALT Analysis Anosmia anticipated antiviral therapy Antiviral treatment antivirals Appendix Arm arrhythmia AST Asthma Asymptomatic Autoimmune blinded to treatment Blinding blood sample BMI Breastfeeding childbearing potential Cholangitis chronic chronic hepatitis Chronic kidney disease chronic liver disease chronic respiratory disease cirrhosis clinical condition collected combination therapy Comorbidity concealed Concomitant concomitant medications conducted COPD coryza cough COVID-19 COVID-19 disease COVID-19 vaccine criteria current Date Day decrease defined Deleterious detectable diabetes died disease dissemination dose double-blind Duration early treatment effective EGFR element enrolled enrolment Ethnicity examined exclusion criteria factorial design Favipiravir female female participant Fever followed by Free Gender headache heart disease Hepatitis hepatotoxicity HIV infection hospital hospitalisation hypersensitivity hypertension in viral include inclusion criteria ingredient investigator investigators Ischaemic heart disease Kidney disease liver Liver disease London Lopinavir Lopinavir/ritonavir malaise male participant male participants measure medication Mutation myalgia Myocardial infarction no symptom non-hospitalised not limited number obesity objective observational studies observational study oral outcome Outpatient outpatients participant Participants partner percentage pharmacokinetic phase IIa Placebo placebo-controlled placebo-controlled trial positive presence or absence Primary outcome Proportion of participant Protease inhibitor protocol randomised randomised controlled trial Rate Registered Registration respiratory Respiratory disease risk Ritonavir Safety Saliva saliva samples Sample size SARS-CoV-2 secondary Secondary outcomes Shortness of breath smoker smoking smoking status Stage status steatohepatitis Stool Study protocol supplementary material Symptom symptom onset symptomatic tested therapy Toxicity Treatment treatment allocation Trial trial medication Trial registration undetectable United Kingdom upper respiratory tract vaccine trial valvular valvular heart disease Viral Viral load website with COVID-19 [DOI] 10.1186/s13063-021-05139-2 PMC 바로가기 [Article Type] Letter
Outbreak of SARS-CoV-2: challenge for diagnosis and medical management in patients with left ventricular assist device: a case seriesCase Series Published on 2021-03-072022-10-31 Journal: European Heart Journal: Case Reports [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Admission Antibiotics anticoagulation ARDS assist bleeding Blood Case series case sery Comorbidities Comorbidity Computed tomography coronavirus coronavirus disease cough COVID-19 COVID-19 diagnosis COVID-19 pandemic Day Diagnosis diagnosis of COVID-19 discharged Dyspnoea Fever high risk Hospitalization Hospitalized Inconclusive International Left ventricular assist device LVAD management moderate Mortality nasal nasal oxygen nasopharyngeal non-invasive ventilation normalized outbreak overlapped Patient patients performed positive radiological evidence SARS-CoV-2 Shortness of breath specific symptom Supportive treatment Symptom syndrome the patient thrombotic event treated ventricular vulnerable patient was tested [DOI] 10.1093/ehjcr/ytaa447 PMC 바로가기 [Article Type] Case Series
Recruitment and Results Reporting of COVID-19 Randomized Clinical Trials Registered in the First 100 Days of the Pandemic팬데믹 초기 100일 동안 등록된 COVID-19 무작위 임상 시험의 모집 및 결과 보고Research Published on 2021-03-012022-09-10 Journal: JAMA Network Open [Category] 임상, [키워드] Analysis clinical coronavirus disease Coronavirus disease 2019 COVID-19 Day randomized clinical trial randomized clinical trials recruitment Registered reported Reporting Result [DOI] 10.1001/jamanetworkopen.2021.0330 PMC 바로가기 [Article Type] Research