System-Wide Accelerated Implementation of Telemedicine in Response to COVID-19: Mixed Methods EvaluationOriginal Paper Published on 2020-10-062022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] accelerated Care challenge Clinical practice conducted control group COVID-19 COVID-19 pandemic diagnostic domains group Health health services evaluation implementation male network NPs objective Patient Patient satisfaction physician produced question receiving response Result retrospective Satisfaction score telehealth Telemedicine telemedicine visits Treatment virtual medicine was measured [DOI] 10.2196/22146 PMC 바로가기 [Article Type] Original Paper
Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure Research Published on 2020-10-052022-10-05 Journal: Nature Genetics [Category] 변종, [키워드] accumulate Analysis Cancer Chromatin structure dataset distribution domains Factor generate Genome genome organization human cancers inactive Mutation mutational processe mutational processes Replication somatic mutation Therapeutic strategies understanding Variation whole-genome [DOI] 10.1038/s41588-020-0708-0 [Article Type] Research
Optimizing Pandemic Preparedness and Response Through Health Information Systems: Lessons Learned From Ebola to COVID-19Concepts in Disaster Medicine Published on 2020-10-022022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, MERS, [키워드] activities approach Community Contact tracing COVID-19 COVID-19 pandemic Critical Diagnosis domains Ebola effective globe health emergency Health information system health information systems health system Health systems strengthening lesson novel coronavirus disease offer outbreak Outbreak response pandemic Pandemics preparedness provided recommendation Resilience resources response risk supported sustained Treatment West [DOI] 10.1017/dmp.2020.361 PMC 바로가기 [Article Type] Concepts in Disaster Medicine
Psychological Impact of Coronavirus Disease 2019 Among Italians During the First Week of LockdownPsychiatry Published on 2020-09-302022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] 95% CI adaptive affective age Anxiety collected coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional Defense defense mechanisms Depression distress domains Emotion regulation female gender globe Government greater IES-R Impact Intervention investigated Italian Italy less lockdown measure mechanism mental health Odds ratio pandemic pandemic (COVID-19) positive post-traumatic Post-traumatic stress post-traumatic stress symptom protective factor Psychological distress psychological Impact quarantine Resilience Result Symptoms was related Week [DOI] 10.3389/fpsyt.2020.576597 PMC 바로가기 [Article Type] Psychiatry
Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infectionReview Published on 2020-09-242022-10-04 Journal: Virus research [Category] MERS, SARS, 신약개발, 치료제, [키워드] 3CL pro Abstract ACE2 acute respiratory syndrome Affect Angiotensin-converting enzyme anti-SARS-CoV-2 Antiviral approach assays caused China Compound coronavirus disease Coronavirus-2 coughing COVID-19 COVID-19 infection current cysteine protease derivative derivatives develop disease domains Drug discovery drug target drugs effective Genetic globe Helicase herbal medicines host cell receptor individual lack MERS MERS-CoV Middle East natural natural compounds outbreak pandemic pandemic of COVID-19 physical RdRP reported required researcher respiratory respiratory syndrome coronavirus RNA-dependent RNA polymerase S1 and S2 Safe SARS SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection similarity spike glycoprotein target therapeutic agent therapeutic agents therapeutic efficacy viral disease viral infections Viral protein [DOI] 10.1016/j.virusres.2020.198169 PMC 바로가기 [Article Type] Review
Flexible, Functional, and Familiar: Characteristics of SARS-CoV-2 Spike Protein EvolutionMicrobiology Published on 2020-09-172022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition Amino acid binding conserved correlated domains Evolution examined flexibility Host host cell host like Human immune system humans infect Interaction molecular molecular evolution N-terminal domain phylogenetics predicted related virus related viruses residue residues SARS-CoV-2 SARS-CoV-2 S protein selection pressure Sequence motifs spike Spike protein structural flexibility structural modeling structure alignment subset the receptor-binding domain the S protein virus [DOI] 10.3389/fmicb.2020.02112 PMC 바로가기 [Article Type] Microbiology
The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2Genome Replication and Regulation of Viral Gene Expression Published on 2020-09-162022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome affecting Alpha Amino acid antiviral drug Betacoronavirus betacoronaviruses boost can be used complex coronavirus CoV CoVs Critical decrease displaying domains enzymatic activity enzyme evaluated example Exoribonuclease Frequency Genetic genetics genome replication guanine-N7-methyltransferase In vitro assay MERS-CoV MHV Middle East MONITOR mouse hepatitis virus mRNA mutant mutants Mutation nidovirus nonstructural protein nsp14 Nsps observation occurred phenotype Phenotypes progeny promote Proofreading purified replicase replicate Replication replication fidelity replicative reported respiratory syndrome coronavirus reverse genetics RNA genome RNA synthesis SARS-CoV SARS-CoV-2 sequence identity single mutant subunit Support thought viral RNA synthesis viruses while [DOI] 10.1128/JVI.01246-20 PMC 바로가기 [Article Type] Genome Replication and Regulation of Viral Gene Expression
Digital pathology and computational image analysis in nephropathology Reviews Published on 2020-08-262022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] acquisition Analysis applied approach clinically consortia data extraction Digital disease disease categories domains ecosystem generate histopathological homogeneous identify individual information Interpretation Kidney diseases machine-learning management oncology pathology Patient progression renal Repository risk shifting subject supported tissue Treatment [DOI] 10.1038/s41581-020-0321-6 [Article Type] Reviews
Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional studyOriginal Research Published on 2020-08-212022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] Admission affected Complication complications conducted COVID-19 COVID-19 pandemic cross discharge domains evaluate female Health care system hospital ICU Impact indicate Infectious complications Khalid King measure Measures median Nurse objective oncology outcome outcome measures outcomes pandemic parameter participant Patient Patient care Patient satisfaction Patient's satisfaction patients patients died positive patient postoperative provided reported required Result retrospective Retrospective cross-sectional study Safe Satisfaction Saudi Arabia selective Surgeries surgical Surgical Procedure sustained the patient treated university [DOI] 10.1016/j.amsu.2020.08.020 PMC 바로가기 [Article Type] Original Research
Knowledge of Health Care Professionals and Medical Students Regarding Covid-19 in a Tertiary Care Hospital in NepalOriginal Article Published on 2020-07-312022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] COVID-19, SARS, [키워드] health care professionals analyzed approval Attitude Care carried collected college COVID-19 diagnostic disease domains forms Google group Health Health care Health Science healthcare hospital infection control Intervention knowledge knowledge score lack management Nepal no significant difference Practice professional provided questionnaire Research Responder Spread Statistical Package student Tertiary was used [DOI] 10.31729/jnma.4995 PMC 바로가기 [Article Type] Original Article