Design of a Recombinant Multivalent Epitope Vaccine Based on SARS-CoV-2 and Its Variants in Immunoinformatics Approaches면역정보학 접근법에서 SARS-CoV-2 및 그 변이체에 기반한 재조합 다가 에피토프 백신의 설계Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] allergen antigen epitope antigen epitopes approach B-cell epitope caused cellular conformational Coverage COVID-19 cytotoxic T lymphocyte docking effective Epidemic epitope Epitopes global public health Humoral immunity Immune simulation immunoinformatics IMPROVE in vitro in vivo Interaction linear B-cell epitope linear B-cell epitopes linker lymphocyte multivalent multivalent vaccine mutated virus Protein recombinant SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened strain strong interaction T lymphocyte the vaccine tlr-3 Vaccine variant variants VoC [DOI] 10.3389/fimmu.2022.884433 PMC 바로가기 [Article Type] Article
Structural mapping of antibody landscapes to human betacoronavirus spike proteins인간 베타 코로나바이러스 스파이크 단백질에 대한 항체 지형의 구조적 매핑Article Published on 2022-05-062022-09-12 Journal: Science Advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Analysis antibody Antibody Response antigenic complexes convalescent CoVs cross-reactive disease severity epitope epitope mapping General population HKU1 human betacoronavirus human CoV Immunity infections molecular OC43 polyclonal reactivity SARS-CoV-2 SARS-CoV-2-infected individuals seasonal coronavirus sera serum antibodies specificity spike Spike protein β-CoV β-CoVs [DOI] 10.1126/sciadv.abn2911 PMC 바로가기 [Article Type] Article
Structural basis of nanobodies neutralizing SARS-CoV-2 variantsSARS-CoV-2 변이체를 중화시키는 나노바디의 구조적 기초Article Published on 2022-05-052022-09-11 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 receptor antibody bi-paratopic nanobodies binding site block complex conserved contribute coronavirus coronavirus epidemics crystal structure domain epitope immunized inhibit nanobody neutralization potency Neutralizing neutralizing antibody other coronavirus overlap Pandemics RBD Receptor-binding domain resolved SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus significantly Spike protein Structure structures target the spike protein variants of SARS-CoV-2 Viral viral escape virus X-ray crystallography [DOI] 10.1016/j.str.2022.02.011 PMC 바로가기 [Article Type] Article
Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단, [키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing [DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article
Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapyCOVID-19 치료를 위한 SARS-CoV-2 변이체를 중화하는 인간 흡입 가능한 항체 단편Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aerosol aerosol therapy animal models anti-COVID-19 antibody antibody antibody fragment caused cell-cell fusion cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 pathology COVID-19 therapy Critical delta variant Efficiency epitope Human human single-chain antibody Immune status independent Infection inhalation inhibit Intervention intranasal intranasal administration nebulization neutralize Neutralizing other variant other variants phage display Resilience respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variant neutralization scFv severe acute respiratory syndrome Coronavirus single-chain variable fragment Spike protein stability subject the SARS-CoV-2 therapy [DOI] 10.1016/j.ymthe.2022.02.013 PMC 바로가기 [Article Type] Article
Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2SARS-CoV-2 S1-RBD와 수용체 ACE2 간의 항원 교차 반응성Article Published on 2022-05-042022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome addition amino acid residue Analysis analyzed angiotensin converting enzyme 2 angiotensin-converting enzyme 2 anti-ACE2 antibody antibody Antibody binding antigenic autoantibody bind binding Control coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical cross-react cross-reactivity denatured disease severity docking domain enzyme epitope higher affinity human cell increase in indicated mAb measurement mechanism mice molecular molecular mimicry monoclonal antibody overlapping patients with COVID-19 peptide positive correlation protein-protein interaction receptor receptor ACE2 recognize responsible SARS-CoV-2 SARS-COV-2 infection sera Serum level significantly significantly higher the binding affinity the S1 subunit the spike protein transmission electron microscopy virus western blotting [DOI] 10.3389/fimmu.2022.868724 PMC 바로가기 [Article Type] Article
Monoclonal antibodies for malaria prevention말라리아 예방을 위한 단일클론항체Review Published on 2022-05-042022-09-12 Journal: Molecular therapy : the journal of the American So [Category] MERS, 말라리아, 진단, [키워드] antibody antigenic target approach cloned complex COVID-19 pandemic demonstrated disease Diseases Efficacy epitope expressed hosts Infection Infectious disease limitation malaria modulate monoclonal antibody pathogen progression of disease Protein provide Research safety profile single B cell specificity starting point Transmission unique while widespread [DOI] 10.1016/j.ymthe.2022.04.001 PMC 바로가기 [Article Type] Review
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection보편적 에피토프 선택을 위한 SARS-CoV-2 스파이크 단백질의 유전 및 구조 분석Article Published on 2022-05-032022-09-11 Journal: Molecular Biology and Evolution [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility addition Amino acid amino acid sequence approach Comparative conserved coronavirus coronavirus diseases COVID-19 determine epitope Epitopes explain Genetic genome replication immunogenic molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated mutational rate observation omicron Omicron variant performed predicted Protein SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant SARS-CoV-2 variants Selection sequence Sequence analysis spike translation Universal utility vaccine candidate vaccine candidates Vaccine development variant variants variants of SARS-CoV-2 [DOI] 10.1093/molbev/msac091 PMC 바로가기 [Article Type] Article
Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus Research Published on 2022-05-022022-10-05 Journal: Nature Communications [Category] 변종, 신종인플루엔자, 치료제, [키워드] Amino acid antibody antigenic antiviral drugs binding characterized circulating conformational conserved Critical cross-neutralization dependent on determinant determine effective ENhance epitope functional fusion peptide germline gene H1N1 H3N2 IAV in vitro in vivo influenza A virus influenza vaccine Influenza virus Lineage MOST neutralize neutralizing antibody reactivity residue selected strain virus [DOI] 10.1038/s41467-022-29950-w [Article Type] Research