functions – Page 20 – Communicable Diseases Research

Cannabinoids for SARS-CoV-2 and is there evidence of their therapeutic efficacy?

Article

Published on 2021-08-302022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

Development of a Web GIS for small-scale detection and analysis of COVID-19 (SARS-CoV-2) cases based on volunteered geographic information for the city of Cologne, Germany, in July/August 2020

2020년 7~8월 독일 쾰른시의 자발적 지리정보를 기반으로 코로나19(SARS-CoV-2) 사례의 소규모 탐지 및 분석을 위한 웹 GIS 개발

Research

Published on 2021-08-282022-09-10
Journal: International Journal of Health Geographics [Category] MERS, SARS, 치료기술,

[키워드] added addition Affect Analysis article Care collected conjunction coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 case COVID-19 cases creation development example feasibility functions General Data Protection Regulation Geographical Information Systems (GIS) Germany Health Health care help human participant human participants implementation infections information Information System Intervention legal aspect legal aspects North Rhine-Westphalia official open Open source pandemic Perspective processing provide residential building Result SARS-CoV-2 spatial information System Trade Trial registration Web Web GIS
[DOI] 10.1186/s12942-021-00290-0 PMC 바로가기 [Article Type] Research

Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis Syndrome

Neuroscience

Published on 2021-08-272022-10-31
Journal: Frontiers in Neuroscience [Category] COVID-19,

[키워드] accelerated Atypical autonomic Autonomic nervous system brain region Cancer cellular combinatorial therapeutics component COVID-19 COVID-19 sequelae Critical care Crosstalk deregulation evolutionary processes FDA-approved drug fibrosis functional functions homeostasis homeostatic impairment in-hospital mortality Interaction manifestation nervous nervous system neurological organ parameter Phenotypes predicted Premature premature aging promote Regulatory renin-angiotensin system SARS-COV-2 infection SARS-CoV-2-host interactions subset syndrome systemic manifestation tissue tissue degeneration to define unique
[DOI] 10.3389/fnins.2021.727060 PMC 바로가기 [Article Type] Neuroscience

Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies

항 바이러스 약물 테스트 및 유전자 기능 연구를위한 비 감염성 SARS-COV-2 레플리 콘의 구성

Article

Published on 2021-08-252022-08-31
Journal: Journal of Virology [Category] MERS, SARS, 신약개발, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral compounds antiviral drug antiviral drugs antivirals BAC Bacterial biosafety biosafety level Biosafety Level 3 BSL2 BSL3 catalytic site catalytic sites catastrophic caused chromosomal construction contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic deleting demonstrated detect DNA dose-dependent manner drug Drug administration effective vaccine Effective vaccines effort expressing food function functions genetics global public health in viral inhibited level 2 level 3 nano luciferase nLuc nonstructural protein 15 nucleocapsid nucleocapsid protein outbreak pandemic performed Plasmid principle proof Protein reduced Remdesivir Replication replicon reporter respiratory resulting reverse genetics SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus significantly Spread Testing the SARS-CoV-2 transcript transfecting Vero E6 VERO E6 cells Viral viral pathogen viral replication Viral RNA
[DOI] 10.1128/JVI.00687-21 PMC 바로가기 [Article Type] Article

Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 Infection

HCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다

Article

Published on 2021-08-252022-09-11
Journal: Cells [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis
[DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article

A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA

SARS-CoV-2 RNA의 신속한 검출을 위한 비효소, 등온 가닥 치환 및 증폭 분석

Article

Published on 2021-08-242022-09-10
Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술,

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

시리아 햄스터의 시간적 omics 분석은 중간 정도의 COVID-19에 대한 세포 효과기 반응을 풉니다.

Article

Published on 2021-08-112022-09-10
Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료법,

[키워드] Adaptive immunity alterations Analysis Anti-viral blood sample Blood samples Cell cellular cellular mechanism cellular mechanisms Cellular responses COVID-19 COVID-19 patients COVID19 Cytotoxic T cell Cytotoxic T cells dataset datasets disease severity Endothelial cell endothelial cells epithelial cell epithelial cells Evidence expression functions Genes hamster identify IgM antibodies IgM antibody immune response immune responses Infection inflammatory lung injury Innate immunity longitudinal analysis lung Lung injury Lungs Macrophage macrophages Mechanisms of disease Moderate COVID-19 monocyte Monocyte-derived macrophages Pathomechanism Pathomechanisms post infection pro-inflammatory Pro-inflammatory genes proteomics response SARS-CoV-2 SARS-COV-2 infection scRNA-seq Subtypes T cell T cells Temporal Therapeutic strategies transcriptional response Viral viral clearance viral infection
[DOI] 10.1038/s41467-021-25030-7 PMC 바로가기 [Article Type] Article

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication

SARS-COV-2 복제에서 NSP7, NSP8 및 NSP12의 과도 및 안정화 된 복합체

Articles

Published on 2021-08-032022-09-10
Journal: Biophysical Journal [Category] MERS, SARS, 유전자 메커니즘,

[키워드] activities addition amplify atomic Combination complex complexation complexes component components conducted conformation Coordinate crystal structure crystal structures Crystallography defined Disruption DNA form functions greater high-resolution crystal structure Host host immune responses immune responses Interaction make up mechanism mRNA new virus Nsp12 Nsp7 NSP8 Propagation Protein Proteins recognizing Replication reported responsible RNA RNA-dependent RNA polymerase RTC SANS SARS-CoV-2 SARS-CoV-2 replication SAXS scattering size exclusion chromatography Structure Transcription Transient viability Viral Viral proteins Viral RNA virus
[DOI] 10.1016/j.bpj.2021.06.006 PMC 바로가기 [Article Type] Articles

Impact of Perceived Severity of COVID-19 (SARS-COV-2) on Mental Health of University Students of Pakistan: The Mediating Role of Muslim Religiosity

Psychiatry

Published on 2021-08-022022-10-31
Journal: Frontiers in Psychiatry [Category] COVID-19,

The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses

코로나바이러스의 치명적인 내부 얼굴: SARS, MERS 및 COVID19 바이러스의 신장 친화성

Review

Published on 2021-08-012022-09-11
Journal: Iubmb Life [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] 2019-nCoV ACE2 acute respiratory distress acute respiratory distress syndrome ARDS attacked cause Cell cells characterized Complication coronavirus Coronavirus infection CoV infection COVID19 damages distal DPP4 failure functions heart humans induce infected patients infecting infective kidney kidney tissue knowledge liver mechanism MERS MERS-CoV MERS-CoV infection mortality rate Novel coronavirus organ outbreak pandemic pathology Patient Proteinuria provided receptor renal dysfunction renal failure renal impairment respiratory distress Respiratory distress syndrome SARS SARS-CoV SARS-CoV-2 syndrome target triggered viral infection viral invasion virus
[DOI] 10.1002/iub.2516 PMC 바로가기 [Article Type] Review