Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientistsResearch article Published on 2021-06-012022-10-05 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, [키워드] AutoDock AutoDock vina coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation help homologous information inhibitor Interaction Main protease (Mpro) inhibitor modify molecular docking Molecular modeling tutorial MPro pandemic Pandemics peptide Peptide inhibitor protease protocol provide SARS Coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 Mpro structure-based design Structure-based drug design (SBDD) structures the SARS-CoV-2 UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.1016/j.ejmech.2021.113390 [Article Type] Research article
SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees우려되는 SARS-CoV-2 변이체는 COVID-19 회복기 기증자와 백신에서 체액성 반응을 부분적으로 탈출하지만 T 세포 반응은 회피하지 않습니다Article Published on 2021-05-252022-09-11 Journal: Science Immunology [Category] Fulltext, SARS, 변종, 진단, 치료기술, [키워드] addition antibody antigens B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants BNT162b2 CD4 Cellular immune response cellular immune responses Cohort COVID-19 convalescent donor COVID-19 disease cross-reactivity detect elicited exhibited functional HCW Health care Health care worker homologous humoral Humoral and cellular immune responses Humoral immunity Immune escape immune response immune responses individuals Mild Mild COVID-19 disease mononuclear cell mononuclear cells mutated Mutation neutralizing capacity no difference no differences not affected peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells Protein raised recall Region required S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose seronegative single vaccination Specific stimulated T cells T-cell activation T-cell Response T-cell-mediated immunity vaccination vaccinee variant variants virus virus-specific T cell wild type [DOI] 10.1126/sciimmunol.abj1750 PMC 바로가기 [Article Type] Article
Ultrafast enzymatic digestion of deoxyribonucleic acid in aqueous microdroplets for sequence discrimination and identificationResearch Article Published on 2021-05-202022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] accelerate approach base bases coronavirus correlation cutoff value demonstrated Deoxyribonuclease digestion DNA DNA fragment DNA fragmentation DNA sequence DNase I gel electrophoresis Genetic genotyping homologous intensities less m/z microbe Microdroplet chemistry molecular weight Mutation polymerase chain PPM produced Quantitative Reaction Rate Acceleration reagent SARS-CoV-2 SARS-CoV-2Orf1ab sequence sickle cell anemia similarity single-nucleotide temperature Tolerance [DOI] 10.1017/qrd.2021.2 PMC 바로가기 [Article Type] Research Article
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice자가 증폭 RNA 및 아데노바이러스 COVID 백신을 사용한 이종 백신 요법은 생쥐에서 강력한 면역 반응을 유도합니다Article Published on 2021-05-172022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] Adaptive immunity Antibody Response Antibody responses boost CD4 T cells Cellular immune response ChAdOx1 clinical trial clinical trials comparable COVID COVID-19 Cytotoxic T cell Cytotoxic T cells demonstrated disease Efficacy example Heterologous heterologous prime-boost heterologous vaccination regimen heterologous vaccination regimens homologous immune response immunogenicity induce Infectious diseases mice Neutralising titre regimen regimens RNA RNA vaccine robust SARS-CoV-2 Single-dose T cells Th1 titre titres vaccination Vaccine Vaccines vectored vaccine viral vectors [DOI] 10.1038/s41467-021-23173-1 PMC 바로가기 [Article Type] Article
Genome-Wide Variation in BetacoronavirusesGenetic Diversity and Evolution Published on 2021-05-122022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antibody Antiviral antiviral drugs bat Betacoronavirus biological property Combination contributing to coronavirus COVID-19 Critical Defense diagnostic test diagnostic tests disorder Evolution form Genetic Genome genomic variation genus Betacoronavirus glycoprotein S highlight homologous Host host adaptation humans implication include infect Infection infection with SARS-CoV-2 manifested MERS-CoV Middle East Mutation natural new strain ORF1b ORF8 Other pathogenicity Probability profile property Protein protein S provide reliability repeated Replication respiratory syndrome coronavirus S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 strain selection pressure strain Strains Trigger Vaccine Vaccine design Variation virus [DOI] 10.1128/JVI.00496-21 PMC 바로가기 [Article Type] Genetic Diversity and Evolution
Interferon antagonism by SARS-CoV-2: a functional study using reverse geneticsSARS-CoV-2에 의한 인터페론 길항작용: 역유전학을 이용한 기능적 연구Article Published on 2021-05-012022-09-11 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome adaptive Amino acid amino acid substitution amino acid substitutions amino acids analysed Analysis antagonistic backbone Bildung Calu Calu-3 cell calu-3 cells camostat camostat mesilate Cell cell entry cell line cellular entry receptor changes COVID-19 cytokine domain ENCODE Epidemic evaluate evaluated expressed fitness Frame functional gene induction Genes Genetic genetic engineering genetics homologous homology host cell host cells interfere interferon interferon antagonism interferon treatment interferon-stimulated gene interferon-stimulated genes investigated IRF3 less luciferase Mutagenesis mutant MX1 nuclear translocation Open reading frame ORF6 phenotype phenotypic Protein Replication residue residues RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sensitivity Severe acute respiratory syndrome strain Strains suppressed TMPRSS2 transcription factor transmission efficiency Treatment type I interferon Vero E6 Vero E6 cell VERO E6 cells virus wild-type [DOI] 10.1016/S2666-5247(21)00027-6 PMC 바로가기 [Article Type] Article
Receptor utilization of angiotensin-converting enzyme 2 (ACE2) indicates a narrower host range of SARS-CoV-2 than that of SARS-CoVACE2의 수용체 활용은 SARS-CoV보다 SARS-CoV-2의 숙주 범위가 더 좁음을 나타냅니다.Article Published on 2021-05-012022-09-11 Journal: Transboundary and emerging diseases [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Amino acid amino acid residue amino acid sequence Amino acid sequences angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) bat bats both viruses caused contributing to coronavirus Coronaviruses CoV COVID-19 pandemic Critical determine ENhance enzyme Epidemic evaluate Genome homologous Host host range Human in vivo indicate inter-species transmission intermediate host key factor less mechanism murine N-terminal pandemic Pandemics pangolin pangolin-CoV pathogenic coronaviruses pseudovirus public health receptor receptor utilization. required SARS-CoV SARS-CoV-2 SARS-related coronavirus Severe acute respiratory syndrome Severe Acute Respiratory Syndrome CoV susceptibility Transmission virus viruses [DOI] 10.1111/tbed.13792 PMC 바로가기 [Article Type] Article
SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold CoronavirusesSARS-CoV-2-혈청 음성 피험자, 감기 코로나바이러스에 교차 반응하는 SARS-CoV-2 핵단백질의 CTL 에피토프 표적Clinical Trial Published on 2021-04-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료제, [키워드] Amino acid analyzed Antiretroviral therapy Beta beta-coronavirus CD4 CD8 CD8+ T-cell circulating Cohort Cold common common cold common cold coronavirus Concentration contribute Course COVID-19 cross-reactive CTL CTL epitope delineation epitope Epitopes healthy donors HIV-1 HIV-1 infection HKU1 HLA allele HLA alleles HLA-A HLA-A*02 HLA-B homologous homology induce Infection majority Mild nucleoprotein observation OC43 Patient peptide peptides potential risk Prospective Study protective role reason risk factor Risk factors SARS-CoV-2 SARS-CoV-2 (2019-nCoV) SARS-COV-2 infection SARS-CoV-2 nucleoprotein sequence severe COVID-19 severe disease subject susceptibility T-cell T-cell epitope T-cell Response T-cell responses T-cells target the SARS-CoV-2 treated [DOI] 10.3389/fimmu.2021.627568 PMC 바로가기 [Article Type] Clinical Trial
Correlates of Neutralization against SARS-CoV-2 Variants of Concern by Early Pandemic Sera초기 유행성 혈청에 의한 우려의 SARS-CoV-2 변종에 대한 중화의 상관 관계Pathogenesis and Immunity Published on 2021-04-282022-09-10 Journal: Journal of Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies B.1.1.7 B.1.351 B.1.351 variant binding characterized clinical feature Cohort concern convalescent COVID-19 convalescent patient COVID-19 pandemic Critical cross-neutralization effective Evidence exacerbate homologous immune responses Immunity immunological Increasing Infection investigated mechanism Mutation N-terminal domain nAb response NAb responses NAb titers natural immunity natural infection neutralization Neutralizing antibodies neutralizing antibody NTD overcome pandemic primary mechanism promote RBD Receptor binding domain reduced reduction in response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly spike gene stimulated subjects susceptibility T cell T cell responses T cells These data Vaccine-induced immunity Vaccines variant variants Virological [DOI] 10.1128/JVI.00404-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
Online biophysical predictions for SARS-CoV-2 proteinsDatabase Published on 2021-04-232022-10-27 Journal: BMC Molecular and Cell Biology [Category] COVID-19, [키워드] addition aggregation backbone Biophysical features conformational COVID-19 determine disorder drug design effort epitope Final functional homologous hypothese immunological inherent limit Major Molecular dynamics simulation Protein protein-protein interaction Proteins provide provided Region researcher SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus sequence Single sequence based predictions structures supplementary material the SARS-CoV-2 three-dimensional structure Variation virus website β-sheet [DOI] 10.1186/s12860-021-00362-w PMC 바로가기 [Article Type] Database