Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohortObservational Study Published on 2021-10-282022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] adjusted clinical Clinical characteristics Cohort cohort study consecutive patient COVID-19 creatinine D-dimer level discharge Epidemic epidemiological hospital Hospital admission Hospital stay Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient ICU admission IMPROVE management mechanical ventilation Mortality New no significant difference observé Older outbreak outcome PaO2/FiO2 ratio Patient prognostic Prospective reduced required second wave therapeutic Treatment [DOI] 10.1371/journal.pone.0258918 PMC 바로가기 [Article Type] Observational Study
Functional Activity of the Complement System in Hospitalized COVID-19 Patients: A Prospective Cohort StudyObservational Study Published on 2021-10-282022-10-04 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] 95% CI Activation activity acute lung injury acute phase Admission Alternative pathway Analysis autopsy studies C1 esterase inhibitor collected complement complement system Concentration confounding factors correlated COVID-19 COVID-19 patient Critically ill death Disease progression disease severities disease severity Factor ficolin-3 Follow-up hospitalized COVID-19 patient hospitalized patient ICU admission implicated in vitro in vivo In-hospital death Inflammation Inflammatory marker IQR lectin pathway male mannose-binding lectin mechanical ventilation median multiple comorbidities no significant difference occurred Pathogenesis pathway Patient PCR-confirmed Primary outcome progression Prospective prospective observational study Protein reduced required Result resulting ROC Curve SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 severe disease significantly significantly lower single-center System the patient threshold Ventilation [DOI] 10.3389/fimmu.2021.765330 PMC 바로가기 [Article Type] Observational Study
Contrastive learning improves critical event prediction in COVID-19 patientsResearch article Published on 2021-10-252022-10-05 Journal: Patterns [Category] 유전자 메커니즘, [키워드] analyses approach AUROC CEL characteristic Conventional coronavirus disease COVID-19 COVID-19 patient Critical dataset deep DSML 3: Development/Pre-production: Data science output has been rolled out/validated across multiple domains/problems effective EHR Electronic health record healthcare hospitalized COVID-19 patient ICU IMPROVE intensive care intubation margin Mortality pandemic Precision predict recall robust tested training data transfer [DOI] 10.1016/j.patter.2021.100389 [Article Type] Research article
Evaluation of a multiplex PCR screening approach to identify community-acquired bacterial co-infections in COVID-19: a multicenter prospective cohort study of the German competence network of community-acquired pneumonia (CAPNETZ)COVID-19에서 지역사회 획득 세균 동시 감염을 식별하기 위한 다중 PCR 스크리닝 접근 방식 평가: 지역사회 획득 폐렴의 독일 역량 네트워크(CAPNETZ)에 대한 다기관 전향적 코호트 연구Observational Study Published on 2021-10-232022-09-10 Journal: Infection [Category] MERS, SARS, 임상, 치료기술, [키워드] Admission analyzed antibiotic stewardship Antibiotic treatment approach bacterial co-infection bacterial pathogen Bacterial pathogens Chain Reaction clinical Co-infection Cohort Community-acquired co-infection community-acquired pneumonia competence coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients early phase evaluate facilitate Frequency Germany Haemophilus Haemophilus influenzae Hospital admission Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU admission identify inflammation markers knowledge Legionella pneumophila Moraxella catarrhalis Mortality mortality rate Most patient Most patients multicenter multiplex Multiplex PCR Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs network no correlation on admission pathogen detection Pathogens Patient PCR Pneumonia polymerase chain polymerase chain reaction positive PCR positive PCR result prospective cohort study purulent sputum Rapid multiplex PCR diagnostic recruited Result reverse transcription risk Risk assessment significantly sputum Staphylococcus aureus Streptococcus pneumoniae supplementary material Switzerland Treatment Treatment strategies treatment strategy [DOI] 10.1007/s15010-021-01720-8 PMC 바로가기 [Article Type] Observational Study
Association of Myocardial Enzyme Abnormality with Clinical Outcomes of Patients with COVID-19: A Retrospective StudyResearch Article Published on 2021-10-222022-10-31 Journal: Disease Markers [Category] COVID-19, MERS, [키워드] Abnormalities abnormality Analysis analyzed association clinical Clinical characteristics clinical outcomes collected Comorbidities COVID-19 COVID-19 patient COVID-19 patients Critical CRP death enzyme hospitalized COVID-19 patient increasing age indicated Inflammation information investigated Laboratory laboratory-confirmed majority marker Mortality multivariable logistic regression Myocardial myocardial damage myocardial injury Novel coronavirus Older age outcome Patient patients Pneumonia regression analysis Result Retrospective study risk factor severity severity of COVID-19 the patient was used Wuhan [DOI] 10.1155/2021/3440714 PMC 바로가기 [Article Type] Research Article
Acute Myocardial Injury and Rhabdomyolysis in COVID-19 Patients: Incidence and MortalityCardiology Published on 2021-10-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 Angiotensin converting enzyme 2 (ACE2) angiotensin-converting enzyme 2 benefit binding Cardiomyopathy cardiovascular disease caused cohort study coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients creatine kinase (ck) Critical CVD defined elevated enzyme female fiber fibrosis Frequency greater higher risk Hospitalized hospitalized COVID-19 patient hospitalized patients Host hyperinflammatory cytokine storm hypoxic immune in-hospital mortality incidence indirect mechanism Injury ischemic injury male material Mortality mortality rate muscle myocardial injury myocardial ischemia type 2(mi type 2) myocarditis Necrosis Odds ratio outcome pathophysiology Patient patients with COVID-19 Primary outcome Result retrospective rhabdomyolysis SARS-CoV-2 virus serum Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) significantly higher Skeletal muscle Stress systemic cytokine Troponin-T [DOI] 10.7759/cureus.18899 PMC 바로가기 [Article Type] Cardiology
Oral Microbiome Alterations and SARS-CoV-2 Saliva Viral Load in Patients with COVID-19Research Article Published on 2021-10-132022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] 16S rRNA Affect alteration Clinical outcome Cohort Control controls COVID-19 COVID-19 disease COVID-19 patient hospitalized COVID-19 patient Influenza Interaction load Microbiome microbiota morbidity and mortality not differ oral Prevotella respiratory virus reverse transcription PCR RT-PCR Saliva saliva microbiome SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load Sequencing Streptococcus Viral load with COVID-19 [DOI] 10.1128/Spectrum.00055-21 PMC 바로가기 [Article Type] Research Article
Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19Article Published on 2021-10-122022-10-04 Journal: Scientific Reports [Category] MERS, 임상, [키워드] 4C Mortality added adjusted age all-cause mortality analyzed approach arterial Arterial stiffness blood pressure calculated Cohort Comorbidity component control group COVID-19 COVID-19 patient Deceased Estimated evaluate hospitalized COVID-19 patient hospitalized patient IMPROVE longitudinal cohort study marker Mortality Patient patients with COVID-19 Predictive markers prognostic Prognostic markers Prognostic value provided pulse recruited reflect retrospective risk factor risk stratification Sex subject survivor Therapeutic strategies total population viral infection with COVID-19 [DOI] 10.1038/s41598-021-99050-0 PMC 바로가기 [Article Type] Article
Obesity Correlates With Pronounced Aberrant Innate Immune Responses in Hospitalized Aged COVID-19 Patients비만은 입원한 노인 COVID-19 환자의 비정상적인 선천성 면역 반응과 관련이 있습니다Comparative Study Published on 2021-10-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Admission Admissions advanced age age aging Antibody titers BMI caused changes in Chronic low-grade inflammation circulating Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine response Cytokines death defined dysregulated elevated Frequency hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients host response IgG antibody IgG antibody titers immune Immune cell immune cells immune responses individual Infection Inflammatory cytokine inflammatory cytokine production Innate Innate immunity innate response intensive care intensive care unit mediators mitogen monocyte Monocytes obesity occur patients Prevalence respiratory response responsible risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease significant negative correlation subset These data [DOI] 10.3389/fimmu.2021.760288 PMC 바로가기 [Article Type] Comparative Study
Cross-sectional study on the proportion of smell and taste disturbances in hospitalized COVID-19 patientsCross-sectional Study Published on 2021-10-082022-10-04 Journal: Annals of Medicine and Surgery [Category] 변종, [키워드] Academy Ageusia Anosmia ART Characteristics conditions coronavirus disease-2019 COVID-19 COVID-19 patients COVID-19 symptom cross-sectional cross-sectional study defined hospitalized COVID-19 patient identify Indonesia manifested material median Mild moderate Neck occurred Occurrence patients proportion questionnaire reached recruited Reporting required to fill Result severity Smell subject subjects suffered surgery Symptom symptoms of COVID-19 total population was measured [DOI] 10.1016/j.amsu.2021.102909 PMC 바로가기 [Article Type] Cross-sectional Study